Correlation between Maximum Clot Firmness in FIBTEM and Fibrinogen Level in Critical Trauma Patients
Background. Both fibrinogen level and rotational thromboelastometry (ROTEM®) are accurate tests to demonstrate a bleeding tendency. FIBTEM® is one type of ROTEM test to determine the function of fibrinogen. An advantage of FIBTEM is helping physicians make proper decisions for blood component transf...
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Wiley
2019-01-01
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| Series: | Critical Care Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2019/2756461 |
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| author | Supphamongkhon Khunakanan Osaree Akaraborworn Burapat Sangthong Komet Thongkhao |
| author_facet | Supphamongkhon Khunakanan Osaree Akaraborworn Burapat Sangthong Komet Thongkhao |
| author_sort | Supphamongkhon Khunakanan |
| collection | DOAJ |
| description | Background. Both fibrinogen level and rotational thromboelastometry (ROTEM®) are accurate tests to demonstrate a bleeding tendency. FIBTEM® is one type of ROTEM test to determine the function of fibrinogen. An advantage of FIBTEM is helping physicians make proper decisions for blood component transfusions. However, the correlation between fibrinogen level and FIBTEM is still unclear. Objective. The aim of this study was to demonstrate a correlation between maximum clot firmness (MCF) in FIBTEM and fibrinogen level in critical trauma patients. Methods. Data were retrospectively collected from 87 patients who visited the emergency department between May 2017 and January 2019 in Songklanagarind Hospital. Blood specimens were sent for both ROTEM evaluation and fibrinogen level. The data were analysed with STATA program version 12.1. Results. Eighty-seven patients were enrolled in the study over the 21-month period. The patients consisted of 73 males (83.9%) with a median age of 40 years. Seventy-three patients (83.9%) were still alive. The following equation from FIBTEM MCF was used to predict fibrinogen level: fibrinogen level = 138 + (15.2 × FIBTEM MCF) (Lin’s concordance correlation coefficient of 0.52, P<0.001). The results showed a good correlation of FIBTEM MCF to predict patients with hypofibrinogenemia (area under ROC curve = 0.81). Patients with normal fibrinogen levels received significantly fewer units of all types of blood components. Conclusion. FIBTEM MCF had poor prediction of fibrinogen level; however, it can help to identify patients who have hypofibrinogenemia. |
| format | Article |
| id | doaj-art-26574f48e43c4ce3a6b1faade70b03d7 |
| institution | Kabale University |
| issn | 2090-1305 2090-1313 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Critical Care Research and Practice |
| spelling | doaj-art-26574f48e43c4ce3a6b1faade70b03d72025-02-03T06:05:23ZengWileyCritical Care Research and Practice2090-13052090-13132019-01-01201910.1155/2019/27564612756461Correlation between Maximum Clot Firmness in FIBTEM and Fibrinogen Level in Critical Trauma PatientsSupphamongkhon Khunakanan0Osaree Akaraborworn1Burapat Sangthong2Komet Thongkhao3Department of Surgery, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110, ThailandDivision of Trauma and Critical Care, Department of Surgery, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110, ThailandDivision of Trauma and Critical Care, Department of Surgery, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110, ThailandDivision of Trauma and Critical Care, Department of Surgery, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110, ThailandBackground. Both fibrinogen level and rotational thromboelastometry (ROTEM®) are accurate tests to demonstrate a bleeding tendency. FIBTEM® is one type of ROTEM test to determine the function of fibrinogen. An advantage of FIBTEM is helping physicians make proper decisions for blood component transfusions. However, the correlation between fibrinogen level and FIBTEM is still unclear. Objective. The aim of this study was to demonstrate a correlation between maximum clot firmness (MCF) in FIBTEM and fibrinogen level in critical trauma patients. Methods. Data were retrospectively collected from 87 patients who visited the emergency department between May 2017 and January 2019 in Songklanagarind Hospital. Blood specimens were sent for both ROTEM evaluation and fibrinogen level. The data were analysed with STATA program version 12.1. Results. Eighty-seven patients were enrolled in the study over the 21-month period. The patients consisted of 73 males (83.9%) with a median age of 40 years. Seventy-three patients (83.9%) were still alive. The following equation from FIBTEM MCF was used to predict fibrinogen level: fibrinogen level = 138 + (15.2 × FIBTEM MCF) (Lin’s concordance correlation coefficient of 0.52, P<0.001). The results showed a good correlation of FIBTEM MCF to predict patients with hypofibrinogenemia (area under ROC curve = 0.81). Patients with normal fibrinogen levels received significantly fewer units of all types of blood components. Conclusion. FIBTEM MCF had poor prediction of fibrinogen level; however, it can help to identify patients who have hypofibrinogenemia.http://dx.doi.org/10.1155/2019/2756461 |
| spellingShingle | Supphamongkhon Khunakanan Osaree Akaraborworn Burapat Sangthong Komet Thongkhao Correlation between Maximum Clot Firmness in FIBTEM and Fibrinogen Level in Critical Trauma Patients Critical Care Research and Practice |
| title | Correlation between Maximum Clot Firmness in FIBTEM and Fibrinogen Level in Critical Trauma Patients |
| title_full | Correlation between Maximum Clot Firmness in FIBTEM and Fibrinogen Level in Critical Trauma Patients |
| title_fullStr | Correlation between Maximum Clot Firmness in FIBTEM and Fibrinogen Level in Critical Trauma Patients |
| title_full_unstemmed | Correlation between Maximum Clot Firmness in FIBTEM and Fibrinogen Level in Critical Trauma Patients |
| title_short | Correlation between Maximum Clot Firmness in FIBTEM and Fibrinogen Level in Critical Trauma Patients |
| title_sort | correlation between maximum clot firmness in fibtem and fibrinogen level in critical trauma patients |
| url | http://dx.doi.org/10.1155/2019/2756461 |
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