Protection from Metabolic Dysregulation, Obesity, and Atherosclerosis by Citrus Flavonoids: Activation of Hepatic PGC1α-Mediated Fatty Acid Oxidation
Studies in a multitude of models including cell culture, animal and clinical studies demonstrate that citrus-derived flavonoids have therapeutic potential to attenuate dyslipidemia, correct hyperinsulinemia and hyperglycemia, and reduce atherosclerosis. Emerging evidence suggests the metabolic regul...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2012/857142 |
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| _version_ | 1832553040879550464 |
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| author | Erin E. Mulvihill Murray W. Huff |
| author_facet | Erin E. Mulvihill Murray W. Huff |
| author_sort | Erin E. Mulvihill |
| collection | DOAJ |
| description | Studies in a multitude of models including cell culture, animal and clinical studies demonstrate that citrus-derived flavonoids have therapeutic potential to attenuate dyslipidemia, correct hyperinsulinemia and hyperglycemia, and reduce atherosclerosis. Emerging evidence suggests the metabolic regulators, PPARα and PGC1α, are targets of the citrus flavonoids, and their activation may be at least partially responsible for mediating their metabolic effects. Molecular studies will add significantly to the concept of these flavonoids as viable and promising therapeutic agents to treat the dysregulation of lipid homeostasis, metabolic disease, and its cardiovascular complications. |
| format | Article |
| id | doaj-art-263d0611764d49dbb92ad30f27dcca72 |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-263d0611764d49dbb92ad30f27dcca722025-02-03T05:57:07ZengWileyPPAR Research1687-47571687-47652012-01-01201210.1155/2012/857142857142Protection from Metabolic Dysregulation, Obesity, and Atherosclerosis by Citrus Flavonoids: Activation of Hepatic PGC1α-Mediated Fatty Acid OxidationErin E. Mulvihill0Murray W. Huff1Vascular Biology Group, Robarts Research Institute, 100 Perth Drive, London, ON, N6A 5K8, CanadaVascular Biology Group, Robarts Research Institute, 100 Perth Drive, London, ON, N6A 5K8, CanadaStudies in a multitude of models including cell culture, animal and clinical studies demonstrate that citrus-derived flavonoids have therapeutic potential to attenuate dyslipidemia, correct hyperinsulinemia and hyperglycemia, and reduce atherosclerosis. Emerging evidence suggests the metabolic regulators, PPARα and PGC1α, are targets of the citrus flavonoids, and their activation may be at least partially responsible for mediating their metabolic effects. Molecular studies will add significantly to the concept of these flavonoids as viable and promising therapeutic agents to treat the dysregulation of lipid homeostasis, metabolic disease, and its cardiovascular complications.http://dx.doi.org/10.1155/2012/857142 |
| spellingShingle | Erin E. Mulvihill Murray W. Huff Protection from Metabolic Dysregulation, Obesity, and Atherosclerosis by Citrus Flavonoids: Activation of Hepatic PGC1α-Mediated Fatty Acid Oxidation PPAR Research |
| title | Protection from Metabolic Dysregulation, Obesity, and Atherosclerosis by Citrus Flavonoids: Activation of Hepatic PGC1α-Mediated Fatty Acid Oxidation |
| title_full | Protection from Metabolic Dysregulation, Obesity, and Atherosclerosis by Citrus Flavonoids: Activation of Hepatic PGC1α-Mediated Fatty Acid Oxidation |
| title_fullStr | Protection from Metabolic Dysregulation, Obesity, and Atherosclerosis by Citrus Flavonoids: Activation of Hepatic PGC1α-Mediated Fatty Acid Oxidation |
| title_full_unstemmed | Protection from Metabolic Dysregulation, Obesity, and Atherosclerosis by Citrus Flavonoids: Activation of Hepatic PGC1α-Mediated Fatty Acid Oxidation |
| title_short | Protection from Metabolic Dysregulation, Obesity, and Atherosclerosis by Citrus Flavonoids: Activation of Hepatic PGC1α-Mediated Fatty Acid Oxidation |
| title_sort | protection from metabolic dysregulation obesity and atherosclerosis by citrus flavonoids activation of hepatic pgc1α mediated fatty acid oxidation |
| url | http://dx.doi.org/10.1155/2012/857142 |
| work_keys_str_mv | AT erinemulvihill protectionfrommetabolicdysregulationobesityandatherosclerosisbycitrusflavonoidsactivationofhepaticpgc1amediatedfattyacidoxidation AT murraywhuff protectionfrommetabolicdysregulationobesityandatherosclerosisbycitrusflavonoidsactivationofhepaticpgc1amediatedfattyacidoxidation |