Practical Approach for the Determination of Response Factors of Impurities in Drugs by HPLC
For the determination of accurate quantity of impurities in the samples authentic impurity standards or response factors at a given wavelength must be known. In the presented work a convenient method for determination of relative response factors of impurities has been described without using an aut...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2011/462364 |
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| _version_ | 1832562930931990528 |
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| author | Dharmendra Kushwah Haresh B. Patel Praveen K. Sinha Pijush K. Jana |
| author_facet | Dharmendra Kushwah Haresh B. Patel Praveen K. Sinha Pijush K. Jana |
| author_sort | Dharmendra Kushwah |
| collection | DOAJ |
| description | For the determination of accurate quantity of impurities in the samples authentic impurity standards or response factors at a given wavelength must be known. In the presented work a convenient method for determination of relative response factors of impurities has been described without using an authentic impurities standard. An approach for the determination of response factors of the impurities where impurity standard is physically not available was developed and verified using different approaches. One such method was developed and verified by RP-HPLC using Cosmosil C18 MS-II column at UV 238 nm. Two different approaches were employed and the verification of correctness of approach was done using a known related substance of known response factor. |
| format | Article |
| id | doaj-art-263a7e9f5dab42168d004f452f8ccaa4 |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-263a7e9f5dab42168d004f452f8ccaa42025-02-03T01:21:24ZengWileyE-Journal of Chemistry0973-49452090-98102011-01-01841504151110.1155/2011/462364Practical Approach for the Determination of Response Factors of Impurities in Drugs by HPLCDharmendra Kushwah0Haresh B. Patel1Praveen K. Sinha2Pijush K. Jana3Unimark Remedies Ltd., 337, Kerala Nalsarover Road, Vill. Kerala, IndiaUnimark Remedies Ltd., 337, Kerala Nalsarover Road, Vill. Kerala, IndiaUnimark Remedies Ltd., 337, Kerala Nalsarover Road, Vill. Kerala, IndiaUnimark Remedies Ltd., 337, Kerala Nalsarover Road, Vill. Kerala, IndiaFor the determination of accurate quantity of impurities in the samples authentic impurity standards or response factors at a given wavelength must be known. In the presented work a convenient method for determination of relative response factors of impurities has been described without using an authentic impurities standard. An approach for the determination of response factors of the impurities where impurity standard is physically not available was developed and verified using different approaches. One such method was developed and verified by RP-HPLC using Cosmosil C18 MS-II column at UV 238 nm. Two different approaches were employed and the verification of correctness of approach was done using a known related substance of known response factor.http://dx.doi.org/10.1155/2011/462364 |
| spellingShingle | Dharmendra Kushwah Haresh B. Patel Praveen K. Sinha Pijush K. Jana Practical Approach for the Determination of Response Factors of Impurities in Drugs by HPLC E-Journal of Chemistry |
| title | Practical Approach for the Determination of Response Factors of Impurities in Drugs by HPLC |
| title_full | Practical Approach for the Determination of Response Factors of Impurities in Drugs by HPLC |
| title_fullStr | Practical Approach for the Determination of Response Factors of Impurities in Drugs by HPLC |
| title_full_unstemmed | Practical Approach for the Determination of Response Factors of Impurities in Drugs by HPLC |
| title_short | Practical Approach for the Determination of Response Factors of Impurities in Drugs by HPLC |
| title_sort | practical approach for the determination of response factors of impurities in drugs by hplc |
| url | http://dx.doi.org/10.1155/2011/462364 |
| work_keys_str_mv | AT dharmendrakushwah practicalapproachforthedeterminationofresponsefactorsofimpuritiesindrugsbyhplc AT hareshbpatel practicalapproachforthedeterminationofresponsefactorsofimpuritiesindrugsbyhplc AT praveenksinha practicalapproachforthedeterminationofresponsefactorsofimpuritiesindrugsbyhplc AT pijushkjana practicalapproachforthedeterminationofresponsefactorsofimpuritiesindrugsbyhplc |