Neovascular age-related macular degeneration: disease pathogenesis and current state of molecular biomarkers predicting treatment response—a scoping review
Age-related macular degeneration is a major cause of blindness, and the development of anti-vascular endothelial growth factor (VEGF) intravitreal treatments has revolutionised the management of the disease. At the same time, new challenges and unmet needs arose due to the limitations of the current...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2024-05-01
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| Series: | BMJ Open Ophthalmology |
| Online Access: | https://bmjophth.bmj.com/content/9/1/e001516.full |
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| _version_ | 1832086488432508928 |
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| author | Nikolaos Dervenis Eleftherios Agorogiannis Panagiotis Dervenis |
| author_facet | Nikolaos Dervenis Eleftherios Agorogiannis Panagiotis Dervenis |
| author_sort | Nikolaos Dervenis |
| collection | DOAJ |
| description | Age-related macular degeneration is a major cause of blindness, and the development of anti-vascular endothelial growth factor (VEGF) intravitreal treatments has revolutionised the management of the disease. At the same time, new challenges and unmet needs arose due to the limitations of the current therapeutic options. Neovascularisation development during the course of the disease has a complex pathogenetic mechanism, and several biomarkers and their association with treatment outcomes have been investigated. We reviewed the relevant literature about neovascularisation development and biomarkers related to response to treatment. Improving our knowledge on the field can improve patient outcomes and offer personalised care. |
| format | Article |
| id | doaj-art-2630a35cc73845ae9dc061d216c6b80b |
| institution | Kabale University |
| issn | 2397-3269 |
| language | English |
| publishDate | 2024-05-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open Ophthalmology |
| spelling | doaj-art-2630a35cc73845ae9dc061d216c6b80b2025-02-06T14:05:09ZengBMJ Publishing GroupBMJ Open Ophthalmology2397-32692024-05-019110.1136/bmjophth-2023-001516Neovascular age-related macular degeneration: disease pathogenesis and current state of molecular biomarkers predicting treatment response—a scoping reviewNikolaos Dervenis0Eleftherios Agorogiannis1Panagiotis Dervenis2Aristotle University of Thessaloniki, Thessaloniki, GreeceUveitis and Medical Retina, Manchester Royal Eye Hospital, Manchester, UKColchester Hospital University NHS Foundation Trust, Colchester, Essex, UKAge-related macular degeneration is a major cause of blindness, and the development of anti-vascular endothelial growth factor (VEGF) intravitreal treatments has revolutionised the management of the disease. At the same time, new challenges and unmet needs arose due to the limitations of the current therapeutic options. Neovascularisation development during the course of the disease has a complex pathogenetic mechanism, and several biomarkers and their association with treatment outcomes have been investigated. We reviewed the relevant literature about neovascularisation development and biomarkers related to response to treatment. Improving our knowledge on the field can improve patient outcomes and offer personalised care.https://bmjophth.bmj.com/content/9/1/e001516.full |
| spellingShingle | Nikolaos Dervenis Eleftherios Agorogiannis Panagiotis Dervenis Neovascular age-related macular degeneration: disease pathogenesis and current state of molecular biomarkers predicting treatment response—a scoping review BMJ Open Ophthalmology |
| title | Neovascular age-related macular degeneration: disease pathogenesis and current state of molecular biomarkers predicting treatment response—a scoping review |
| title_full | Neovascular age-related macular degeneration: disease pathogenesis and current state of molecular biomarkers predicting treatment response—a scoping review |
| title_fullStr | Neovascular age-related macular degeneration: disease pathogenesis and current state of molecular biomarkers predicting treatment response—a scoping review |
| title_full_unstemmed | Neovascular age-related macular degeneration: disease pathogenesis and current state of molecular biomarkers predicting treatment response—a scoping review |
| title_short | Neovascular age-related macular degeneration: disease pathogenesis and current state of molecular biomarkers predicting treatment response—a scoping review |
| title_sort | neovascular age related macular degeneration disease pathogenesis and current state of molecular biomarkers predicting treatment response a scoping review |
| url | https://bmjophth.bmj.com/content/9/1/e001516.full |
| work_keys_str_mv | AT nikolaosdervenis neovascularagerelatedmaculardegenerationdiseasepathogenesisandcurrentstateofmolecularbiomarkerspredictingtreatmentresponseascopingreview AT eleftheriosagorogiannis neovascularagerelatedmaculardegenerationdiseasepathogenesisandcurrentstateofmolecularbiomarkerspredictingtreatmentresponseascopingreview AT panagiotisdervenis neovascularagerelatedmaculardegenerationdiseasepathogenesisandcurrentstateofmolecularbiomarkerspredictingtreatmentresponseascopingreview |