Modified Glomerular Filtration Rate-Estimating Equations Developed in Asiatic Population for Chinese Patients with Type 2 Diabetes
Objectives. To evaluate eight modified equations developed in Asiatic populations in type 2 diabetic patients in China. Methods. A total of 209 Chinese patients with type 2 diabetes were recruited. Using the technetium—99m diethylenetriaminepentaacetic acid—glomerular filtration rate (GFR) to act as...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
|
| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2014/521071 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832550748844457984 |
|---|---|
| author | Xun Liu Xilian Qiu Chenggang Shi Hui Huang Jianhua Huang Ming Li Tanqi Lou |
| author_facet | Xun Liu Xilian Qiu Chenggang Shi Hui Huang Jianhua Huang Ming Li Tanqi Lou |
| author_sort | Xun Liu |
| collection | DOAJ |
| description | Objectives. To evaluate eight modified equations developed in Asiatic populations in type 2 diabetic patients in China. Methods. A total of 209 Chinese patients with type 2 diabetes were recruited. Using the technetium—99m diethylenetriaminepentaacetic acid—glomerular filtration rate (GFR) to act as the reference, comparisons of their efficiency to estimate GFR in the subjects were made between various equations. Results. Median of difference of the Chinese equation 1 was the lowest (median of difference, 0.51 mL/min/1.73 m2). Median percent of absolute difference of the Chinese equation 2 was less than those of the other equations (26.97 versus ranged from 32.54 to 37.61 mL/min/1.73 m2, [P<0.001 for all]). Precision of the simplified reexpressed MDRD equation was the best (92.9 mL/min/1.73 m2). Accuracies of the Chinese equation 2 were greater (P<0.05 for all). There was also an improvement in chronic kidney disease (CKD) stage misclassification of the Chinese equation 2 (55.0 versus ranged from 61.2 to 64.6%, [P<0.001 for all]). However, the 30% accuracies of all the equations were less than 70%. Conclusions. Our study highlighted a limitation in the use of the above equations in the majority of Chinese diabetic subjects. A better equation is needed in order to give an accurate estimation of GFR in type 2 diabetic patients in China. |
| format | Article |
| id | doaj-art-2613a4c5f2cd434c80b6f138a5e265a1 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-2613a4c5f2cd434c80b6f138a5e265a12025-02-03T06:05:55ZengWileyInternational Journal of Endocrinology1687-83371687-83452014-01-01201410.1155/2014/521071521071Modified Glomerular Filtration Rate-Estimating Equations Developed in Asiatic Population for Chinese Patients with Type 2 DiabetesXun Liu0Xilian Qiu1Chenggang Shi2Hui Huang3Jianhua Huang4Ming Li5Tanqi Lou6Division of Nephrology, Department of Internal Medicine, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, ChinaDepartment of Laboratory Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, ChinaDivision of Nephrology, Department of Internal Medicine, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, ChinaDepartment of Cardiology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, ChinaDepartment of Laboratory Medicine, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, ChinaDivision of Nephrology, Department of Internal Medicine, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, ChinaDivision of Nephrology, Department of Internal Medicine, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, ChinaObjectives. To evaluate eight modified equations developed in Asiatic populations in type 2 diabetic patients in China. Methods. A total of 209 Chinese patients with type 2 diabetes were recruited. Using the technetium—99m diethylenetriaminepentaacetic acid—glomerular filtration rate (GFR) to act as the reference, comparisons of their efficiency to estimate GFR in the subjects were made between various equations. Results. Median of difference of the Chinese equation 1 was the lowest (median of difference, 0.51 mL/min/1.73 m2). Median percent of absolute difference of the Chinese equation 2 was less than those of the other equations (26.97 versus ranged from 32.54 to 37.61 mL/min/1.73 m2, [P<0.001 for all]). Precision of the simplified reexpressed MDRD equation was the best (92.9 mL/min/1.73 m2). Accuracies of the Chinese equation 2 were greater (P<0.05 for all). There was also an improvement in chronic kidney disease (CKD) stage misclassification of the Chinese equation 2 (55.0 versus ranged from 61.2 to 64.6%, [P<0.001 for all]). However, the 30% accuracies of all the equations were less than 70%. Conclusions. Our study highlighted a limitation in the use of the above equations in the majority of Chinese diabetic subjects. A better equation is needed in order to give an accurate estimation of GFR in type 2 diabetic patients in China.http://dx.doi.org/10.1155/2014/521071 |
| spellingShingle | Xun Liu Xilian Qiu Chenggang Shi Hui Huang Jianhua Huang Ming Li Tanqi Lou Modified Glomerular Filtration Rate-Estimating Equations Developed in Asiatic Population for Chinese Patients with Type 2 Diabetes International Journal of Endocrinology |
| title | Modified Glomerular Filtration Rate-Estimating Equations Developed in Asiatic Population for Chinese Patients with Type 2 Diabetes |
| title_full | Modified Glomerular Filtration Rate-Estimating Equations Developed in Asiatic Population for Chinese Patients with Type 2 Diabetes |
| title_fullStr | Modified Glomerular Filtration Rate-Estimating Equations Developed in Asiatic Population for Chinese Patients with Type 2 Diabetes |
| title_full_unstemmed | Modified Glomerular Filtration Rate-Estimating Equations Developed in Asiatic Population for Chinese Patients with Type 2 Diabetes |
| title_short | Modified Glomerular Filtration Rate-Estimating Equations Developed in Asiatic Population for Chinese Patients with Type 2 Diabetes |
| title_sort | modified glomerular filtration rate estimating equations developed in asiatic population for chinese patients with type 2 diabetes |
| url | http://dx.doi.org/10.1155/2014/521071 |
| work_keys_str_mv | AT xunliu modifiedglomerularfiltrationrateestimatingequationsdevelopedinasiaticpopulationforchinesepatientswithtype2diabetes AT xilianqiu modifiedglomerularfiltrationrateestimatingequationsdevelopedinasiaticpopulationforchinesepatientswithtype2diabetes AT chenggangshi modifiedglomerularfiltrationrateestimatingequationsdevelopedinasiaticpopulationforchinesepatientswithtype2diabetes AT huihuang modifiedglomerularfiltrationrateestimatingequationsdevelopedinasiaticpopulationforchinesepatientswithtype2diabetes AT jianhuahuang modifiedglomerularfiltrationrateestimatingequationsdevelopedinasiaticpopulationforchinesepatientswithtype2diabetes AT mingli modifiedglomerularfiltrationrateestimatingequationsdevelopedinasiaticpopulationforchinesepatientswithtype2diabetes AT tanqilou modifiedglomerularfiltrationrateestimatingequationsdevelopedinasiaticpopulationforchinesepatientswithtype2diabetes |