Patient Characteristics Associated with HCV Treatment Adherence, Treatment Completion, and Sustained Virologic Response in HIV Coinfected Patients
Background. Hepatitis C (HCV) treatment efficacy among HIV patients is limited by poor treatment adherence and tolerance, but few studies have examined the psychosocial determinants of treatment adherence and outcomes. Methods. Chart abstracted and survey data were collected on 72 HIV patients who h...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | AIDS Research and Treatment |
| Online Access: | http://dx.doi.org/10.1155/2011/903480 |
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| _version_ | 1832561964382945280 |
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| author | Glenn Wagner Karen Chan Osilla Jeffrey Garnett Bonnie Ghosh-Dastidar Laveeza Bhatti Matthew Bidwell Goetz Mallory Witt |
| author_facet | Glenn Wagner Karen Chan Osilla Jeffrey Garnett Bonnie Ghosh-Dastidar Laveeza Bhatti Matthew Bidwell Goetz Mallory Witt |
| author_sort | Glenn Wagner |
| collection | DOAJ |
| description | Background. Hepatitis C (HCV) treatment efficacy among HIV patients is limited by poor treatment adherence and tolerance, but few studies have examined the psychosocial determinants of treatment adherence and outcomes. Methods. Chart abstracted and survey data were collected on 72 HIV patients who had received pegylated interferon and ribavirin to assess correlates of treatment adherence, completion, and sustained virologic response (SVR). Results. Nearly half (46%) the sample had active psychiatric problems and 13% had illicit drug use at treatment onset; 28% reported <100% treatment adherence, 38% did not complete treatment (mostly due to virologic nonresponse), and intent to treat SVR rate was 49%. Having a psychiatric diagnosis was associated with nonadherence, while better HCV adherence was associated with both treatment completion and SVR. Conclusions. Good mental health may be an indicator of HCV treatment adherence readiness, which is in turn associated with treatment completion and response, but further research is needed with new HCV treatments emerging. |
| format | Article |
| id | doaj-art-26112745db6846ba9b8ef9825643dab4 |
| institution | Kabale University |
| issn | 2090-1240 2090-1259 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | AIDS Research and Treatment |
| spelling | doaj-art-26112745db6846ba9b8ef9825643dab42025-02-03T01:23:45ZengWileyAIDS Research and Treatment2090-12402090-12592011-01-01201110.1155/2011/903480903480Patient Characteristics Associated with HCV Treatment Adherence, Treatment Completion, and Sustained Virologic Response in HIV Coinfected PatientsGlenn Wagner0Karen Chan Osilla1Jeffrey Garnett2Bonnie Ghosh-Dastidar3Laveeza Bhatti4Matthew Bidwell Goetz5Mallory Witt6Health Unit, RAND Corporation, 1776 Main Street, P.O. Box 2138, Santa Monica, CA 90407, USAHealth Unit, RAND Corporation, 1776 Main Street, P.O. Box 2138, Santa Monica, CA 90407, USAHealth Unit, RAND Corporation, Arlington, VA 22202, USAHealth Unit, RAND Corporation, 1776 Main Street, P.O. Box 2138, Santa Monica, CA 90407, USAAIDS Healthcare Foundation, Los Angeles, CA 90028, USAInfectious Diseases Section, Greater Los Angeles Veterans Administration, Los Angeles, CA 90073, USALos Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Los Angeles, CA 90509, USABackground. Hepatitis C (HCV) treatment efficacy among HIV patients is limited by poor treatment adherence and tolerance, but few studies have examined the psychosocial determinants of treatment adherence and outcomes. Methods. Chart abstracted and survey data were collected on 72 HIV patients who had received pegylated interferon and ribavirin to assess correlates of treatment adherence, completion, and sustained virologic response (SVR). Results. Nearly half (46%) the sample had active psychiatric problems and 13% had illicit drug use at treatment onset; 28% reported <100% treatment adherence, 38% did not complete treatment (mostly due to virologic nonresponse), and intent to treat SVR rate was 49%. Having a psychiatric diagnosis was associated with nonadherence, while better HCV adherence was associated with both treatment completion and SVR. Conclusions. Good mental health may be an indicator of HCV treatment adherence readiness, which is in turn associated with treatment completion and response, but further research is needed with new HCV treatments emerging.http://dx.doi.org/10.1155/2011/903480 |
| spellingShingle | Glenn Wagner Karen Chan Osilla Jeffrey Garnett Bonnie Ghosh-Dastidar Laveeza Bhatti Matthew Bidwell Goetz Mallory Witt Patient Characteristics Associated with HCV Treatment Adherence, Treatment Completion, and Sustained Virologic Response in HIV Coinfected Patients AIDS Research and Treatment |
| title | Patient Characteristics Associated with HCV Treatment Adherence, Treatment Completion, and Sustained Virologic Response in HIV Coinfected Patients |
| title_full | Patient Characteristics Associated with HCV Treatment Adherence, Treatment Completion, and Sustained Virologic Response in HIV Coinfected Patients |
| title_fullStr | Patient Characteristics Associated with HCV Treatment Adherence, Treatment Completion, and Sustained Virologic Response in HIV Coinfected Patients |
| title_full_unstemmed | Patient Characteristics Associated with HCV Treatment Adherence, Treatment Completion, and Sustained Virologic Response in HIV Coinfected Patients |
| title_short | Patient Characteristics Associated with HCV Treatment Adherence, Treatment Completion, and Sustained Virologic Response in HIV Coinfected Patients |
| title_sort | patient characteristics associated with hcv treatment adherence treatment completion and sustained virologic response in hiv coinfected patients |
| url | http://dx.doi.org/10.1155/2011/903480 |
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