Association between herpes simplex virus infection and Alzheimer’s disease biomarkers: analysis within the MAPT trial
Abstract In vitro and animal studies have suggested that inoculation with herpes simplex virus 1 (HSV-1) can lead to amyloid deposits, hyperphosphorylation of tau, and/or neuronal loss. Here, we studied the association between HSV-1 and Alzheimer’s disease biomarkers in humans. Our sample included 1...
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Nature Portfolio
2025-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-84583-x |
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| author | Morgane Linard Isabelle Garrigue Bruno Vellas Nicola Coley Henrik Zetterberg Kaj Blennow Nicholas James Ashton Pierre Payoux Anne-Sophie Salabert Jean-François Dartigues Joachim Mazere Sandrine Andrieu Catherine Helmer |
| author_facet | Morgane Linard Isabelle Garrigue Bruno Vellas Nicola Coley Henrik Zetterberg Kaj Blennow Nicholas James Ashton Pierre Payoux Anne-Sophie Salabert Jean-François Dartigues Joachim Mazere Sandrine Andrieu Catherine Helmer |
| author_sort | Morgane Linard |
| collection | DOAJ |
| description | Abstract In vitro and animal studies have suggested that inoculation with herpes simplex virus 1 (HSV-1) can lead to amyloid deposits, hyperphosphorylation of tau, and/or neuronal loss. Here, we studied the association between HSV-1 and Alzheimer’s disease biomarkers in humans. Our sample included 182 participants at risk of cognitive decline from the Multidomain Alzheimer Preventive Trial who had HSV-1 plasma serology and an amyloid PET scan. Plasma Aβ42/40 ratio, neurofilament light chain and p-tau181 were also available for a sub-sample of participants. Multivariate linear regressions were performed and stratified by APOE4 genotype. The median age was 74.0 years, 85.2% were infected with HSV-1. Infected participants tended to have a lower cortical amyloid load than uninfected participants (β = -0.08, p = 0.06), especially those suspected of reactivating HSV-1 most frequently (i.e. with a high anti-HSV-1 IgG level; n = 58, β = -0.09 p = 0.04). After stratification, the association was only significant in APOE4 carriers (n = 43, β = -0.21 p = 0.01). No association was found with the plasma biomarkers. The trend toward lower cortical amyloid load in HSV-1-infected participants was unexpected given the pre-existing literature and may be explained either by a modified immune response in HSV-1 infected subjects which could favour the clearance of amyloid deposits or by a selection bias. |
| format | Article |
| id | doaj-art-260cbbe1d526489bb4ed348f96fa03ad |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-260cbbe1d526489bb4ed348f96fa03ad2025-01-19T12:21:20ZengNature PortfolioScientific Reports2045-23222025-01-0115111010.1038/s41598-024-84583-xAssociation between herpes simplex virus infection and Alzheimer’s disease biomarkers: analysis within the MAPT trialMorgane Linard0Isabelle Garrigue1Bruno Vellas2Nicola Coley3Henrik Zetterberg4Kaj Blennow5Nicholas James Ashton6Pierre Payoux7Anne-Sophie Salabert8Jean-François Dartigues9Joachim Mazere10Sandrine Andrieu11Catherine Helmer12INSERM U1219 Bordeaux Population Health Research Center, University of BordeauxCNRS, MFP, UMR 5234, University of BordeauxGérontopôle de Toulouse, Institut du Vieillissement, University Hospital of ToulouseINSERM, CERPOP, U1295, University of ToulouseDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of GothenburgDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of GothenburgDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of GothenburgNuclear Medicine Department, University Hospital of ToulouseINSERM ToNIC, U1214, University of ToulouseINSERM U1219 Bordeaux Population Health Research Center, University of BordeauxNuclear Medicine Department, University Hospital of BordeauxINSERM, CERPOP, U1295, University of ToulouseINSERM, Bergonié Institute, BPH, U1219, CIC-P 1401, University of BordeauxAbstract In vitro and animal studies have suggested that inoculation with herpes simplex virus 1 (HSV-1) can lead to amyloid deposits, hyperphosphorylation of tau, and/or neuronal loss. Here, we studied the association between HSV-1 and Alzheimer’s disease biomarkers in humans. Our sample included 182 participants at risk of cognitive decline from the Multidomain Alzheimer Preventive Trial who had HSV-1 plasma serology and an amyloid PET scan. Plasma Aβ42/40 ratio, neurofilament light chain and p-tau181 were also available for a sub-sample of participants. Multivariate linear regressions were performed and stratified by APOE4 genotype. The median age was 74.0 years, 85.2% were infected with HSV-1. Infected participants tended to have a lower cortical amyloid load than uninfected participants (β = -0.08, p = 0.06), especially those suspected of reactivating HSV-1 most frequently (i.e. with a high anti-HSV-1 IgG level; n = 58, β = -0.09 p = 0.04). After stratification, the association was only significant in APOE4 carriers (n = 43, β = -0.21 p = 0.01). No association was found with the plasma biomarkers. The trend toward lower cortical amyloid load in HSV-1-infected participants was unexpected given the pre-existing literature and may be explained either by a modified immune response in HSV-1 infected subjects which could favour the clearance of amyloid deposits or by a selection bias.https://doi.org/10.1038/s41598-024-84583-x |
| spellingShingle | Morgane Linard Isabelle Garrigue Bruno Vellas Nicola Coley Henrik Zetterberg Kaj Blennow Nicholas James Ashton Pierre Payoux Anne-Sophie Salabert Jean-François Dartigues Joachim Mazere Sandrine Andrieu Catherine Helmer Association between herpes simplex virus infection and Alzheimer’s disease biomarkers: analysis within the MAPT trial Scientific Reports |
| title | Association between herpes simplex virus infection and Alzheimer’s disease biomarkers: analysis within the MAPT trial |
| title_full | Association between herpes simplex virus infection and Alzheimer’s disease biomarkers: analysis within the MAPT trial |
| title_fullStr | Association between herpes simplex virus infection and Alzheimer’s disease biomarkers: analysis within the MAPT trial |
| title_full_unstemmed | Association between herpes simplex virus infection and Alzheimer’s disease biomarkers: analysis within the MAPT trial |
| title_short | Association between herpes simplex virus infection and Alzheimer’s disease biomarkers: analysis within the MAPT trial |
| title_sort | association between herpes simplex virus infection and alzheimer s disease biomarkers analysis within the mapt trial |
| url | https://doi.org/10.1038/s41598-024-84583-x |
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