An Experimental In Vivo Model to Characterize “Heavy Legs” Symptom in Topical Formulations
The “Heavy legs” symptom is regarded as an early expression of chronic venous failure, estimated to affect 40% of the population in developing countries. A new methodology is proposed to approach the “tired or heavy legs” symptom. Seven females with this complaint applied a standard topical formulat...
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | Dermatology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2009/547039 |
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| author | Pedro Contreiras Pinto Luís Monteiro Rodrigues |
| author_facet | Pedro Contreiras Pinto Luís Monteiro Rodrigues |
| author_sort | Pedro Contreiras Pinto |
| collection | DOAJ |
| description | The “Heavy legs” symptom is regarded as an early expression of chronic venous failure, estimated to affect 40% of the population in developing countries. A new methodology is proposed to approach the “tired or heavy legs” symptom. Seven females with this complaint applied a standard topical formulation during 28 days in one leg randomly chosen. Local blood flow records were obtained instantaneously and during postural change with a laser doppler flowmeter (LDF). High-frequency sonography and local morphometry were also obtained at Days 0, 14, and 28. When compared with D0, LDF values present a significant decrease of both basal and dynamical values after Day 14 and Day 28 suggesting that this effect may result from the formulation application, also involving the related massage. Centimetric measurements and sonographic analysis also supported those inferences. The proposed methodology can evaluate the dynamical changes of “heavy legs” symptom and eventually be very useful to assess the related claim support. |
| format | Article |
| id | doaj-art-2607cb1dc5794e16af31f181dc03e9d4 |
| institution | Kabale University |
| issn | 1687-6105 1687-6113 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Dermatology Research and Practice |
| spelling | doaj-art-2607cb1dc5794e16af31f181dc03e9d42025-02-03T01:11:09ZengWileyDermatology Research and Practice1687-61051687-61132009-01-01200910.1155/2009/547039547039An Experimental In Vivo Model to Characterize “Heavy Legs” Symptom in Topical FormulationsPedro Contreiras Pinto0Luís Monteiro Rodrigues1Experimental Dermatology Unit, Universidade Lusófona de Humanidades e Tecnologias, Campo Grande 376, 1749-024 Lisbon, PortugalExperimental Dermatology Unit, Universidade Lusófona de Humanidades e Tecnologias, Campo Grande 376, 1749-024 Lisbon, PortugalThe “Heavy legs” symptom is regarded as an early expression of chronic venous failure, estimated to affect 40% of the population in developing countries. A new methodology is proposed to approach the “tired or heavy legs” symptom. Seven females with this complaint applied a standard topical formulation during 28 days in one leg randomly chosen. Local blood flow records were obtained instantaneously and during postural change with a laser doppler flowmeter (LDF). High-frequency sonography and local morphometry were also obtained at Days 0, 14, and 28. When compared with D0, LDF values present a significant decrease of both basal and dynamical values after Day 14 and Day 28 suggesting that this effect may result from the formulation application, also involving the related massage. Centimetric measurements and sonographic analysis also supported those inferences. The proposed methodology can evaluate the dynamical changes of “heavy legs” symptom and eventually be very useful to assess the related claim support.http://dx.doi.org/10.1155/2009/547039 |
| spellingShingle | Pedro Contreiras Pinto Luís Monteiro Rodrigues An Experimental In Vivo Model to Characterize “Heavy Legs” Symptom in Topical Formulations Dermatology Research and Practice |
| title | An Experimental In Vivo Model to Characterize “Heavy Legs” Symptom in Topical Formulations |
| title_full | An Experimental In Vivo Model to Characterize “Heavy Legs” Symptom in Topical Formulations |
| title_fullStr | An Experimental In Vivo Model to Characterize “Heavy Legs” Symptom in Topical Formulations |
| title_full_unstemmed | An Experimental In Vivo Model to Characterize “Heavy Legs” Symptom in Topical Formulations |
| title_short | An Experimental In Vivo Model to Characterize “Heavy Legs” Symptom in Topical Formulations |
| title_sort | experimental in vivo model to characterize heavy legs symptom in topical formulations |
| url | http://dx.doi.org/10.1155/2009/547039 |
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