Effect of Interleukin-17 in the Activation of Monocyte Subsets in Patients with ST-Segment Elevation Myocardial Infarction
Interleukin- (IL-) 17 is increased in acute myocardial infarction (AMI) and plays a key role in inflammatory diseases through its involvement in the activation of leukocytes. Here, we describe for the first time the effect of IL-17 in the migration and activation of monocyte subsets in patients duri...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2020/5692829 |
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| author | Montserrat Guadalupe Garza-Reyes Mónica Daniela Mora-Ruíz Luis Chávez-Sánchez Alejandra Madrid-Miller Alberto Jose Cabrera-Quintero José Luis Maravillas-Montero Alejandro Zentella-Dehesa Luis Moreno-Ruíz Selene Pastor-Salgado Erick Ramírez-Arias Nataly Pérez-Velázquez Adriana Karina Chávez-Rueda Francisco Blanco-Favela Wendy Guadalupe Vazquez-Gonzalez Alicia Contreras-Rodríguez |
| author_facet | Montserrat Guadalupe Garza-Reyes Mónica Daniela Mora-Ruíz Luis Chávez-Sánchez Alejandra Madrid-Miller Alberto Jose Cabrera-Quintero José Luis Maravillas-Montero Alejandro Zentella-Dehesa Luis Moreno-Ruíz Selene Pastor-Salgado Erick Ramírez-Arias Nataly Pérez-Velázquez Adriana Karina Chávez-Rueda Francisco Blanco-Favela Wendy Guadalupe Vazquez-Gonzalez Alicia Contreras-Rodríguez |
| author_sort | Montserrat Guadalupe Garza-Reyes |
| collection | DOAJ |
| description | Interleukin- (IL-) 17 is increased in acute myocardial infarction (AMI) and plays a key role in inflammatory diseases through its involvement in the activation of leukocytes. Here, we describe for the first time the effect of IL-17 in the migration and activation of monocyte subsets in patients during ST-segment elevation myocardial infarction (STEMI) and post-STEMI. We analyzed the circulating levels of IL-17 in patient plasma. A gradual increase in IL-17 was found in STEMI and post-STEMI patients. Additionally, IL-17 had a powerful effect on the recruitment of CD14++CD16+/CD14+CD16++ monocytes derived from patients post-STEMI compared with the monocytes from patients with STEMI, suggesting that IL-17 recruits monocytes with inflammatory activity post-STEMI. Furthermore, IL-17 increased the expression of TLR4 on CD14+CD16- and CD14++CD16+/CD14+CD16++ monocytes post-STEMI and might enhance the response to danger-associated molecular patterns post-STEMI. Moreover, IL-17 induced secretion of IL-6 from CD14++CD16− and CD14++CD16+/CD14+CD16++ monocytes both in STEMI and in post-STEMI, which indicates that IL-17 has an effect on the secretion of proinflammatory cytokines from monocytes during STEMI and post-STEMI. Overall, we demonstrate that in STEMI and post-STEMI, IL-17 is increased and induces the migration and activation of monocyte subsets, possibly contributing to the inflammatory response through TLR4 and IL-6 secretion. |
| format | Article |
| id | doaj-art-25fc383b936f4b0282d9efeede5a950f |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-25fc383b936f4b0282d9efeede5a950f2025-02-03T01:01:55ZengWileyJournal of Immunology Research2314-88612314-71562020-01-01202010.1155/2020/56928295692829Effect of Interleukin-17 in the Activation of Monocyte Subsets in Patients with ST-Segment Elevation Myocardial InfarctionMontserrat Guadalupe Garza-Reyes0Mónica Daniela Mora-Ruíz1Luis Chávez-Sánchez2Alejandra Madrid-Miller3Alberto Jose Cabrera-Quintero4José Luis Maravillas-Montero5Alejandro Zentella-Dehesa6Luis Moreno-Ruíz7Selene Pastor-Salgado8Erick Ramírez-Arias9Nataly Pérez-Velázquez10Adriana Karina Chávez-Rueda11Francisco Blanco-Favela12Wendy Guadalupe Vazquez-Gonzalez13Alicia Contreras-Rodríguez14Unidad de Investigación Médica en Inmunología, UMAE, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, MexicoUnidad de Investigación Médica en Inmunología, UMAE, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, MexicoUnidad de Investigación Médica en Inmunología, UMAE, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, MexicoDivisión de Programas Educativos de la Coordinación de Educación en Salud, Instituto Mexicano del Seguro Social, Ciudad de México, MexicoUnidad de Bioquímica, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán and Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Programa Institucional de Cáncer de Mama, Depto. Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad de México, MexicoRed de Apoyo a la Investigación, Universidad Nacional Autónoma de México and Instituto Nacional de Ciencias Médicas y Nutrición, Salvador Zubirán, Ciudad de México, MexicoUnidad de Bioquímica, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán and Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Programa Institucional de Cáncer de Mama, Depto. Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad de México, MexicoServicio de Cardiología Adultos, División de Cardiología de la Unidad Médica de Alta Especialidad, Hospital de Cardiología, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, MexicoServicio de Urgencias de la Unidad Médica de Alta Especialidad, Hospital de Cardiología, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, MexicoServicio de Urgencias de la Unidad Médica de Alta Especialidad, Hospital de Cardiología, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, MexicoServicio de Cardiología de la Unidad Médica de Alta Especialidad, Hospital de Especialidades, Dr. Ignacio García Téllez, Instituto Mexicano del Seguro Social, Mérida, Yucatán, MexicoUnidad de Investigación Médica en Inmunología, UMAE, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, MexicoUnidad de Investigación Médica en Inmunología, UMAE, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, MexicoUnidad de Investigación Médica en Inmunología, UMAE, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, MexicoServicio de Gabinetes de la Unidad Médica de Alta Especialidad, Hospital de Cardiología, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, MexicoInterleukin- (IL-) 17 is increased in acute myocardial infarction (AMI) and plays a key role in inflammatory diseases through its involvement in the activation of leukocytes. Here, we describe for the first time the effect of IL-17 in the migration and activation of monocyte subsets in patients during ST-segment elevation myocardial infarction (STEMI) and post-STEMI. We analyzed the circulating levels of IL-17 in patient plasma. A gradual increase in IL-17 was found in STEMI and post-STEMI patients. Additionally, IL-17 had a powerful effect on the recruitment of CD14++CD16+/CD14+CD16++ monocytes derived from patients post-STEMI compared with the monocytes from patients with STEMI, suggesting that IL-17 recruits monocytes with inflammatory activity post-STEMI. Furthermore, IL-17 increased the expression of TLR4 on CD14+CD16- and CD14++CD16+/CD14+CD16++ monocytes post-STEMI and might enhance the response to danger-associated molecular patterns post-STEMI. Moreover, IL-17 induced secretion of IL-6 from CD14++CD16− and CD14++CD16+/CD14+CD16++ monocytes both in STEMI and in post-STEMI, which indicates that IL-17 has an effect on the secretion of proinflammatory cytokines from monocytes during STEMI and post-STEMI. Overall, we demonstrate that in STEMI and post-STEMI, IL-17 is increased and induces the migration and activation of monocyte subsets, possibly contributing to the inflammatory response through TLR4 and IL-6 secretion.http://dx.doi.org/10.1155/2020/5692829 |
| spellingShingle | Montserrat Guadalupe Garza-Reyes Mónica Daniela Mora-Ruíz Luis Chávez-Sánchez Alejandra Madrid-Miller Alberto Jose Cabrera-Quintero José Luis Maravillas-Montero Alejandro Zentella-Dehesa Luis Moreno-Ruíz Selene Pastor-Salgado Erick Ramírez-Arias Nataly Pérez-Velázquez Adriana Karina Chávez-Rueda Francisco Blanco-Favela Wendy Guadalupe Vazquez-Gonzalez Alicia Contreras-Rodríguez Effect of Interleukin-17 in the Activation of Monocyte Subsets in Patients with ST-Segment Elevation Myocardial Infarction Journal of Immunology Research |
| title | Effect of Interleukin-17 in the Activation of Monocyte Subsets in Patients with ST-Segment Elevation Myocardial Infarction |
| title_full | Effect of Interleukin-17 in the Activation of Monocyte Subsets in Patients with ST-Segment Elevation Myocardial Infarction |
| title_fullStr | Effect of Interleukin-17 in the Activation of Monocyte Subsets in Patients with ST-Segment Elevation Myocardial Infarction |
| title_full_unstemmed | Effect of Interleukin-17 in the Activation of Monocyte Subsets in Patients with ST-Segment Elevation Myocardial Infarction |
| title_short | Effect of Interleukin-17 in the Activation of Monocyte Subsets in Patients with ST-Segment Elevation Myocardial Infarction |
| title_sort | effect of interleukin 17 in the activation of monocyte subsets in patients with st segment elevation myocardial infarction |
| url | http://dx.doi.org/10.1155/2020/5692829 |
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