Functions of Fasciculation and Elongation Protein Zeta-1 (FEZ1) in the Brain
Fasciculation and elongation protein zeta-1 (FEZ1) is a mammalian ortholog of the Caenorhabditis elegans UNC-76 protein that possesses four coiled-coil domains and a nuclear localization signal. It is mainly expressed in the brain. Suppression of FEZ1 expression in cultured embryonic neurons causes...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2010.151 |
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| _version_ | 1832564112952918016 |
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| author | Andrés D. Maturana Toshitsugu Fujita Shun'ichi Kuroda |
| author_facet | Andrés D. Maturana Toshitsugu Fujita Shun'ichi Kuroda |
| author_sort | Andrés D. Maturana |
| collection | DOAJ |
| description | Fasciculation and elongation protein zeta-1 (FEZ1) is a mammalian ortholog of the Caenorhabditis elegans UNC-76 protein that possesses four coiled-coil domains and a nuclear localization signal. It is mainly expressed in the brain. Suppression of FEZ1 expression in cultured embryonic neurons causes deficiency of neuronal differentiation. Recently, proteomic techniques revealed that FEZ1 interacts with various intracellular partners, such as signaling, motor, and structural proteins. FEZ1 was shown to act as an antiviral factor. The findings reported so far indicate that FEZ1 is associated with neuronal development, neuropathologies, and viral infection. Based on these accumulating evidences, we herein review the biological functions of FEZ1. |
| format | Article |
| id | doaj-art-25f2a2eb5e364ea08f17f2da2f8f8af9 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-25f2a2eb5e364ea08f17f2da2f8f8af92025-02-03T01:11:42ZengWileyThe Scientific World Journal1537-744X2010-01-01101646165410.1100/tsw.2010.151Functions of Fasciculation and Elongation Protein Zeta-1 (FEZ1) in the BrainAndrés D. Maturana0Toshitsugu Fujita1Shun'ichi Kuroda2Department of Bioengineering, Nagaoka University of Technology, Niigata, JapanResearch Institute for Microbial Diseases, Osaka University, Osaka, JapanGraduate School of Bioagricultural Sciences, Nagoya University, Chikusa, Nagoya, JapanFasciculation and elongation protein zeta-1 (FEZ1) is a mammalian ortholog of the Caenorhabditis elegans UNC-76 protein that possesses four coiled-coil domains and a nuclear localization signal. It is mainly expressed in the brain. Suppression of FEZ1 expression in cultured embryonic neurons causes deficiency of neuronal differentiation. Recently, proteomic techniques revealed that FEZ1 interacts with various intracellular partners, such as signaling, motor, and structural proteins. FEZ1 was shown to act as an antiviral factor. The findings reported so far indicate that FEZ1 is associated with neuronal development, neuropathologies, and viral infection. Based on these accumulating evidences, we herein review the biological functions of FEZ1.http://dx.doi.org/10.1100/tsw.2010.151 |
| spellingShingle | Andrés D. Maturana Toshitsugu Fujita Shun'ichi Kuroda Functions of Fasciculation and Elongation Protein Zeta-1 (FEZ1) in the Brain The Scientific World Journal |
| title | Functions of Fasciculation and Elongation Protein Zeta-1 (FEZ1) in the Brain |
| title_full | Functions of Fasciculation and Elongation Protein Zeta-1 (FEZ1) in the Brain |
| title_fullStr | Functions of Fasciculation and Elongation Protein Zeta-1 (FEZ1) in the Brain |
| title_full_unstemmed | Functions of Fasciculation and Elongation Protein Zeta-1 (FEZ1) in the Brain |
| title_short | Functions of Fasciculation and Elongation Protein Zeta-1 (FEZ1) in the Brain |
| title_sort | functions of fasciculation and elongation protein zeta 1 fez1 in the brain |
| url | http://dx.doi.org/10.1100/tsw.2010.151 |
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