The Effects of Early-Life Predator Stress on Anxiety- and Depression-Like Behaviors of Adult Rats
Childhood emotional trauma contributes significantly to certain psychopathologies, such as post-traumatic stress disorder. In experimental animals, however, whether or not early-life stress results in behavioral abnormalities in adult animals still remains controversial. Here, we investigated both s...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2014/163908 |
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| author | Lu-jing Chen Bing-qing Shen Dan-dan Liu Sheng-tian Li |
| author_facet | Lu-jing Chen Bing-qing Shen Dan-dan Liu Sheng-tian Li |
| author_sort | Lu-jing Chen |
| collection | DOAJ |
| description | Childhood emotional trauma contributes significantly to certain psychopathologies, such as post-traumatic stress disorder. In experimental animals, however, whether or not early-life stress results in behavioral abnormalities in adult animals still remains controversial. Here, we investigated both short-term and long-term changes of anxiety- and depression-like behaviors of Wistar rats after being exposed to chronic feral cat stress in juvenile ages. The 2-week predator stress decreased spontaneous activities immediately following stress but did not increase depression- or anxiety-like behaviors 4 weeks after the stimulation in adulthood. Instead, juvenile predator stress had some protective effects, though not very obvious, in adulthood. We also exposed genetic depression model rats, Wistar Kyoto (WKY) rats, to the same predator stress. In WKY rats, the same early-life predator stress did not enhance anxiety- or depression-like behaviors in both the short-term and long-term. However, the stressed WKY rats showed slightly reduced depression-like behaviors in adulthood. These results indicate that in both normal Wistar rats and WKY rats, early-life predator stress led to protective, rather than negative, effects in adulthood. |
| format | Article |
| id | doaj-art-25eeaa9d30044ceaa455ff927afef04c |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-25eeaa9d30044ceaa455ff927afef04c2025-02-03T05:45:41ZengWileyNeural Plasticity2090-59041687-54432014-01-01201410.1155/2014/163908163908The Effects of Early-Life Predator Stress on Anxiety- and Depression-Like Behaviors of Adult RatsLu-jing Chen0Bing-qing Shen1Dan-dan Liu2Sheng-tian Li3Bio-X Institutes, Shanghai Jiao Tong University, Dongchuan Road 800, Shanghai 200240, ChinaBio-X Institutes, Shanghai Jiao Tong University, Dongchuan Road 800, Shanghai 200240, ChinaBio-X Institutes, Shanghai Jiao Tong University, Dongchuan Road 800, Shanghai 200240, ChinaBio-X Institutes, Shanghai Jiao Tong University, Dongchuan Road 800, Shanghai 200240, ChinaChildhood emotional trauma contributes significantly to certain psychopathologies, such as post-traumatic stress disorder. In experimental animals, however, whether or not early-life stress results in behavioral abnormalities in adult animals still remains controversial. Here, we investigated both short-term and long-term changes of anxiety- and depression-like behaviors of Wistar rats after being exposed to chronic feral cat stress in juvenile ages. The 2-week predator stress decreased spontaneous activities immediately following stress but did not increase depression- or anxiety-like behaviors 4 weeks after the stimulation in adulthood. Instead, juvenile predator stress had some protective effects, though not very obvious, in adulthood. We also exposed genetic depression model rats, Wistar Kyoto (WKY) rats, to the same predator stress. In WKY rats, the same early-life predator stress did not enhance anxiety- or depression-like behaviors in both the short-term and long-term. However, the stressed WKY rats showed slightly reduced depression-like behaviors in adulthood. These results indicate that in both normal Wistar rats and WKY rats, early-life predator stress led to protective, rather than negative, effects in adulthood.http://dx.doi.org/10.1155/2014/163908 |
| spellingShingle | Lu-jing Chen Bing-qing Shen Dan-dan Liu Sheng-tian Li The Effects of Early-Life Predator Stress on Anxiety- and Depression-Like Behaviors of Adult Rats Neural Plasticity |
| title | The Effects of Early-Life Predator Stress on Anxiety- and Depression-Like Behaviors of Adult Rats |
| title_full | The Effects of Early-Life Predator Stress on Anxiety- and Depression-Like Behaviors of Adult Rats |
| title_fullStr | The Effects of Early-Life Predator Stress on Anxiety- and Depression-Like Behaviors of Adult Rats |
| title_full_unstemmed | The Effects of Early-Life Predator Stress on Anxiety- and Depression-Like Behaviors of Adult Rats |
| title_short | The Effects of Early-Life Predator Stress on Anxiety- and Depression-Like Behaviors of Adult Rats |
| title_sort | effects of early life predator stress on anxiety and depression like behaviors of adult rats |
| url | http://dx.doi.org/10.1155/2014/163908 |
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