Gandouling ameliorates Wilson’s disease-associated liver fibrosis in mice with associated faecal microbiome and metabolome remodeling

Gandouling ameliorates Wilson’s disease-associated liver fibrosis in mice with associated faecal microbiome and metabolome remodeling

IntroductionIndividuals with Wilson's disease (WD) exhibit liver fibrosis, a basic pathological change that was recently demonstrated to be dynamic and reversible. The gut microbiota markedly influences the occurrence of WD. Gandouling (GDL), a standardized Chinese herbal formula, has demonstra...

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Main Authors: Lulu Tang, Wei Dong, Danqing Liu, Chenling Zhao, Jie Chen, Yuya Wen, Jingyu Zeng, Ting Dong, Wenming Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Pharmacology
Subjects:
Gandouling
Wilson’s disease
liver fibrosis
toxic milk mice
gut microbiota
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1586171/full
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