Wolfberry extracts inhibit Aβ1-42 aggregation and rescue memory loss of AD drosophila
This study is to investigate the potential of wolfberry water extracts for the treatment of Alzheimer’s disease (AD) and the relationship between their anti-AD property and the geographic locations in China. Total extracts of all wolfberry samples showed the potent to decrease self-induced Aβ1-42 ag...
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2020-03-01
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| Series: | Food Science and Human Wellness |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453019300679 |
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| author | Cai-Hong Li Jun-Li Yang |
| author_facet | Cai-Hong Li Jun-Li Yang |
| author_sort | Cai-Hong Li |
| collection | DOAJ |
| description | This study is to investigate the potential of wolfberry water extracts for the treatment of Alzheimer’s disease (AD) and the relationship between their anti-AD property and the geographic locations in China. Total extracts of all wolfberry samples showed the potent to decrease self-induced Aβ1-42 aggregation and Cu2+-induced Aβ1-42 aggregation and the antioxidant capacity as well as the bioactivity for binding bio-metal. A transgenic drosophila model assay revealed that TE of S1 and S6 (S1-TE and S6-TE) at 100 μg/mL demonstrated the potent rescue effect on memory loss compared to the positive control memantine at 20 μg/mL. Further study also revealed the polysaccharide extracts could contribute to their anti-AD property, and the anti-AD activity conspicuously depends on growing environment. Wolfberry samples S1 and S6 showed much more potent anti-AD property. Meanwhile this study demonstrated that the Chinese commonly consumed wolfberry in boiling water might have the beneficial function to prevent AD pathology. Keywords: Aβ1−42, Antioxidant bioactivity, Anti-AD potential, Bio-metal, Drosophila, Wolfberry |
| format | Article |
| id | doaj-art-25ec7f0c24c84bdea0cf680787752e10 |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2020-03-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-25ec7f0c24c84bdea0cf680787752e102025-02-03T05:18:52ZengTsinghua University PressFood Science and Human Wellness2213-45302020-03-01916470Wolfberry extracts inhibit Aβ1-42 aggregation and rescue memory loss of AD drosophilaCai-Hong Li0Jun-Li Yang1CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics (LICP), Chinese Academy of Sciences (CAS), Lanzhou 730000, PR China; University of Chinese Academy of Sciences, CAS, Beijing 100049, PR ChinaCAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics (LICP), Chinese Academy of Sciences (CAS), Lanzhou 730000, PR China; Corresponding author at: Department of Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics (LICP), Chinese Academy of Sciences (CAS), Lanzhou 730000, PR China.This study is to investigate the potential of wolfberry water extracts for the treatment of Alzheimer’s disease (AD) and the relationship between their anti-AD property and the geographic locations in China. Total extracts of all wolfberry samples showed the potent to decrease self-induced Aβ1-42 aggregation and Cu2+-induced Aβ1-42 aggregation and the antioxidant capacity as well as the bioactivity for binding bio-metal. A transgenic drosophila model assay revealed that TE of S1 and S6 (S1-TE and S6-TE) at 100 μg/mL demonstrated the potent rescue effect on memory loss compared to the positive control memantine at 20 μg/mL. Further study also revealed the polysaccharide extracts could contribute to their anti-AD property, and the anti-AD activity conspicuously depends on growing environment. Wolfberry samples S1 and S6 showed much more potent anti-AD property. Meanwhile this study demonstrated that the Chinese commonly consumed wolfberry in boiling water might have the beneficial function to prevent AD pathology. Keywords: Aβ1−42, Antioxidant bioactivity, Anti-AD potential, Bio-metal, Drosophila, Wolfberryhttp://www.sciencedirect.com/science/article/pii/S2213453019300679 |
| spellingShingle | Cai-Hong Li Jun-Li Yang Wolfberry extracts inhibit Aβ1-42 aggregation and rescue memory loss of AD drosophila Food Science and Human Wellness |
| title | Wolfberry extracts inhibit Aβ1-42 aggregation and rescue memory loss of AD drosophila |
| title_full | Wolfberry extracts inhibit Aβ1-42 aggregation and rescue memory loss of AD drosophila |
| title_fullStr | Wolfberry extracts inhibit Aβ1-42 aggregation and rescue memory loss of AD drosophila |
| title_full_unstemmed | Wolfberry extracts inhibit Aβ1-42 aggregation and rescue memory loss of AD drosophila |
| title_short | Wolfberry extracts inhibit Aβ1-42 aggregation and rescue memory loss of AD drosophila |
| title_sort | wolfberry extracts inhibit aβ1 42 aggregation and rescue memory loss of ad drosophila |
| url | http://www.sciencedirect.com/science/article/pii/S2213453019300679 |
| work_keys_str_mv | AT caihongli wolfberryextractsinhibitab142aggregationandrescuememorylossofaddrosophila AT junliyang wolfberryextractsinhibitab142aggregationandrescuememorylossofaddrosophila |