Effects of metformin on transcriptomic and metabolomic profiles in breast cancer survivors enrolled in the randomized placebo-controlled MetBreCS trial

Effects of metformin on transcriptomic and metabolomic profiles in breast cancer survivors enrolled in the randomized placebo-controlled MetBreCS trial

Abstract Metformin reduces the incidence of breast cancer in patients with obesity and type 2 diabetes. However, our knowledge of the effects of metformin on breast cancer recurrence is limited. Within the randomized double-blind placebo-controlled phase II trial MetBreCS, we examined changes in bre...

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Main Authors: Pouda Panahandeh Strømland, Bjørn-Erik Bertelsen, Kristin Viste, Anastasia Chrysovalantou Chatziioannou, Federica Bellerba, Nivonirina Robinot, Amarine Trolat, Marianne Hauglid Flågeng, Augustin Scalbert, Pekka Keski-Rahkonen, Dorothy D. Sears, Bernardo Bonanni, Sara Gandini, Harriet Johansson, Gunnar Mellgren
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Metformin
Breast cancer recurrence
Sex steroid hormones
17β-estradiol
Estrone
Metabolomics
Online Access:https://doi.org/10.1038/s41598-025-01705-9
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