The Metabolic Features of Tumor-Associated Macrophages: Opportunities for Immunotherapy?
Besides transformed cells, the tumors are composed of various cell types that contribute to undesirable tumor progression. Tumor-associated macrophages (TAMs) are the most abundant innate immune cells in the tumor microenvironment (TME). Within the TME, TAMs exhibit high plasticity and undergo speci...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Analytical Cellular Pathology |
| Online Access: | http://dx.doi.org/10.1155/2021/5523055 |
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| author | Sonja S. Mojsilovic Slavko Mojsilovic Victor H. Villar Juan F. Santibanez |
| author_facet | Sonja S. Mojsilovic Slavko Mojsilovic Victor H. Villar Juan F. Santibanez |
| author_sort | Sonja S. Mojsilovic |
| collection | DOAJ |
| description | Besides transformed cells, the tumors are composed of various cell types that contribute to undesirable tumor progression. Tumor-associated macrophages (TAMs) are the most abundant innate immune cells in the tumor microenvironment (TME). Within the TME, TAMs exhibit high plasticity and undergo specific functional metabolic alterations according to the availability of tumor tissue oxygen and nutrients, thus further contributing to tumorigenesis and cancer progression. Here, we review the main functional TAM metabolic patterns influenced by TME, including glycolysis, amino acid, and fatty acid metabolism. Moreover, this review discusses antitumor immunotherapies that affect TAM functionality by inducing cell repolarizing and metabolic profiles towards an antitumoral phenotype. Also, new macrophage-based cell therapeutic technologies recently developed using chimeric antigen receptor bioengineering are exposed, which may overcome all solid tumor physical barriers impeding the current adoptive cell therapies and contribute to developing novel cancer immunotherapies. |
| format | Article |
| id | doaj-art-25c7e3d6672948f0b4bb2754a8308adc |
| institution | Kabale University |
| issn | 2210-7177 2210-7185 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Analytical Cellular Pathology |
| spelling | doaj-art-25c7e3d6672948f0b4bb2754a8308adc2025-02-03T06:14:10ZengWileyAnalytical Cellular Pathology2210-71772210-71852021-01-01202110.1155/2021/55230555523055The Metabolic Features of Tumor-Associated Macrophages: Opportunities for Immunotherapy?Sonja S. Mojsilovic0Slavko Mojsilovic1Victor H. Villar2Juan F. Santibanez3Laboratory for Immunochemistry, Institute for Medical Research, University of Belgrade, 11129 Belgrade, SerbiaLaboratory of Experimental Hematology and Stem Cells, Institute for Medical Research, University of Belgrade, 11129 Belgrade, SerbiaCRUK Beatson Institute, Glasgow G61 1BD, UKMolecular Oncology Group, Institute for Medical Research, University of Belgrade, 11129 Belgrade, SerbiaBesides transformed cells, the tumors are composed of various cell types that contribute to undesirable tumor progression. Tumor-associated macrophages (TAMs) are the most abundant innate immune cells in the tumor microenvironment (TME). Within the TME, TAMs exhibit high plasticity and undergo specific functional metabolic alterations according to the availability of tumor tissue oxygen and nutrients, thus further contributing to tumorigenesis and cancer progression. Here, we review the main functional TAM metabolic patterns influenced by TME, including glycolysis, amino acid, and fatty acid metabolism. Moreover, this review discusses antitumor immunotherapies that affect TAM functionality by inducing cell repolarizing and metabolic profiles towards an antitumoral phenotype. Also, new macrophage-based cell therapeutic technologies recently developed using chimeric antigen receptor bioengineering are exposed, which may overcome all solid tumor physical barriers impeding the current adoptive cell therapies and contribute to developing novel cancer immunotherapies.http://dx.doi.org/10.1155/2021/5523055 |
| spellingShingle | Sonja S. Mojsilovic Slavko Mojsilovic Victor H. Villar Juan F. Santibanez The Metabolic Features of Tumor-Associated Macrophages: Opportunities for Immunotherapy? Analytical Cellular Pathology |
| title | The Metabolic Features of Tumor-Associated Macrophages: Opportunities for Immunotherapy? |
| title_full | The Metabolic Features of Tumor-Associated Macrophages: Opportunities for Immunotherapy? |
| title_fullStr | The Metabolic Features of Tumor-Associated Macrophages: Opportunities for Immunotherapy? |
| title_full_unstemmed | The Metabolic Features of Tumor-Associated Macrophages: Opportunities for Immunotherapy? |
| title_short | The Metabolic Features of Tumor-Associated Macrophages: Opportunities for Immunotherapy? |
| title_sort | metabolic features of tumor associated macrophages opportunities for immunotherapy |
| url | http://dx.doi.org/10.1155/2021/5523055 |
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