Influence of exogenous glutathione on the system of antioxidant protection of the body in case of comorbid course of chronic obstructive pulmonary disease and chronic pancreatitis
Aim. To study the condition of oxidant-antioxidant system in patients with comorbid course of chronic obstructive pulmonary disease (COPD) and chronic pancreatitis (CP) with oral administration of glutathione. Methods and results. 60 patients with COPD (GOLD1-2, В stage) were examined in the phas...
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Zaporizhzhia State Medical and Pharmaceutical University
2015-08-01
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| Series: | Zaporožskij Medicinskij Žurnal |
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| Online Access: | http://zmj.zsmu.edu.ua/article/view/50273/47712 |
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| author | O. S. Khukhlina O. O. Ursul V. S. Gaydichuk |
| author_facet | O. S. Khukhlina O. O. Ursul V. S. Gaydichuk |
| author_sort | O. S. Khukhlina |
| collection | DOAJ |
| description | Aim. To study the condition of oxidant-antioxidant system in patients with comorbid course of chronic obstructive pulmonary disease (COPD) and chronic pancreatitis (CP) with oral administration of glutathione.
Methods and results. 60 patients with COPD (GOLD1-2, В stage) were examined in the phase of non-infectious exacerbation with comorbid CP in the phase of exacerbation were divided into 2 groups. The main group (2, M) received therapy with hepaval (reduced glutathione per 250 mg twice a day) during 30 days. A tendency to increased activity of reduced glutathione in 1,2 and 1,6 times in the control and main groups was observed (р<0,05).
Conclusion. Treatment with hepaval promotes intensity of LPO processes decrease and restoration of the main factor of the antioxidant protective system in the blood – reduced glutathione. |
| format | Article |
| id | doaj-art-25bf3a1c423b4e0eb10c62b51a639f8e |
| institution | OA Journals |
| issn | 2306-4145 2310-1210 |
| language | English |
| publishDate | 2015-08-01 |
| publisher | Zaporizhzhia State Medical and Pharmaceutical University |
| record_format | Article |
| series | Zaporožskij Medicinskij Žurnal |
| spelling | doaj-art-25bf3a1c423b4e0eb10c62b51a639f8e2025-08-20T01:58:52ZengZaporizhzhia State Medical and Pharmaceutical UniversityZaporožskij Medicinskij Žurnal2306-41452310-12102015-08-0149294http://dx.doi.org/10.14739/2310-1210.2015.4.50273Influence of exogenous glutathione on the system of antioxidant protection of the body in case of comorbid course of chronic obstructive pulmonary disease and chronic pancreatitisO. S. Khukhlina O. O. UrsulV. S. GaydichukAim. To study the condition of oxidant-antioxidant system in patients with comorbid course of chronic obstructive pulmonary disease (COPD) and chronic pancreatitis (CP) with oral administration of glutathione. Methods and results. 60 patients with COPD (GOLD1-2, В stage) were examined in the phase of non-infectious exacerbation with comorbid CP in the phase of exacerbation were divided into 2 groups. The main group (2, M) received therapy with hepaval (reduced glutathione per 250 mg twice a day) during 30 days. A tendency to increased activity of reduced glutathione in 1,2 and 1,6 times in the control and main groups was observed (р<0,05). Conclusion. Treatment with hepaval promotes intensity of LPO processes decrease and restoration of the main factor of the antioxidant protective system in the blood – reduced glutathione.http://zmj.zsmu.edu.ua/article/view/50273/47712Chronic Obstructive Pulmonary DiseaseChronic PancreatitisHepavalOxidative Stress |
| spellingShingle | O. S. Khukhlina O. O. Ursul V. S. Gaydichuk Influence of exogenous glutathione on the system of antioxidant protection of the body in case of comorbid course of chronic obstructive pulmonary disease and chronic pancreatitis Zaporožskij Medicinskij Žurnal Chronic Obstructive Pulmonary Disease Chronic Pancreatitis Hepaval Oxidative Stress |
| title | Influence of exogenous glutathione on the system of antioxidant protection of the body in case of comorbid course of chronic obstructive pulmonary disease and chronic pancreatitis |
| title_full | Influence of exogenous glutathione on the system of antioxidant protection of the body in case of comorbid course of chronic obstructive pulmonary disease and chronic pancreatitis |
| title_fullStr | Influence of exogenous glutathione on the system of antioxidant protection of the body in case of comorbid course of chronic obstructive pulmonary disease and chronic pancreatitis |
| title_full_unstemmed | Influence of exogenous glutathione on the system of antioxidant protection of the body in case of comorbid course of chronic obstructive pulmonary disease and chronic pancreatitis |
| title_short | Influence of exogenous glutathione on the system of antioxidant protection of the body in case of comorbid course of chronic obstructive pulmonary disease and chronic pancreatitis |
| title_sort | influence of exogenous glutathione on the system of antioxidant protection of the body in case of comorbid course of chronic obstructive pulmonary disease and chronic pancreatitis |
| topic | Chronic Obstructive Pulmonary Disease Chronic Pancreatitis Hepaval Oxidative Stress |
| url | http://zmj.zsmu.edu.ua/article/view/50273/47712 |
| work_keys_str_mv | AT oskhukhlina influenceofexogenousglutathioneonthesystemofantioxidantprotectionofthebodyincaseofcomorbidcourseofchronicobstructivepulmonarydiseaseandchronicpancreatitis AT ooursul influenceofexogenousglutathioneonthesystemofantioxidantprotectionofthebodyincaseofcomorbidcourseofchronicobstructivepulmonarydiseaseandchronicpancreatitis AT vsgaydichuk influenceofexogenousglutathioneonthesystemofantioxidantprotectionofthebodyincaseofcomorbidcourseofchronicobstructivepulmonarydiseaseandchronicpancreatitis |