Synthesis of Marine (−)-Pelorol and Future Perspectives
Meroterpenoid-type marine natural compounds have attracted an increasing amount of attention due to their peculiar chemical structures and their potential for the development of therapeutically important probes. Within this group of substances pelorol stands out; it is a natural compound isolated fr...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-09-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/22/9/425 |
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| author | Antonio Rosales Martínez Ignacio Rodríguez-García |
| author_facet | Antonio Rosales Martínez Ignacio Rodríguez-García |
| author_sort | Antonio Rosales Martínez |
| collection | DOAJ |
| description | Meroterpenoid-type marine natural compounds have attracted an increasing amount of attention due to their peculiar chemical structures and their potential for the development of therapeutically important probes. Within this group of substances pelorol stands out; it is a natural compound isolated from marine organisms with a unique structure and an interesting biological profile. In this article, we summarize and highlight the most interesting aspects of the synthetic procedures towards this compound, which have two common key steps. The first is the coupling of a drimanyl derivative with a compound derived from an arene. The second is a Friedel–Crafts cyclization which forms the C ring of the natural product. Despite the synthetic advances achieved so far, we consider that a more efficient synthetic procedures could be carried out, since their synthetic routes are difficult to scale up due to numerous reaction steps and the limitations imposed by the use of some reagents. In this article, we present a new and versatile retrosynthetic analysis of (−)-pelorol and analogs, which is highly desirable for their easy preparation and subsequent broad study of their biological activities. This is a retrosynthetic route that could improve those reported in the literature in terms of cost-effectiveness. |
| format | Article |
| id | doaj-art-25bea5e5280246b394917e15c3b4582c |
| institution | OA Journals |
| issn | 1660-3397 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj-art-25bea5e5280246b394917e15c3b4582c2025-08-20T01:54:18ZengMDPI AGMarine Drugs1660-33972024-09-0122942510.3390/md22090425Synthesis of Marine (−)-Pelorol and Future PerspectivesAntonio Rosales Martínez0Ignacio Rodríguez-García1Department of Chemical Engineering, Escuela Politécnica Superior, University of Sevilla, 41011 Sevilla, SpainOrganic Chemistry, CeiA3, CIAIMBITAL, University of Almería, 04120 Almeria, SpainMeroterpenoid-type marine natural compounds have attracted an increasing amount of attention due to their peculiar chemical structures and their potential for the development of therapeutically important probes. Within this group of substances pelorol stands out; it is a natural compound isolated from marine organisms with a unique structure and an interesting biological profile. In this article, we summarize and highlight the most interesting aspects of the synthetic procedures towards this compound, which have two common key steps. The first is the coupling of a drimanyl derivative with a compound derived from an arene. The second is a Friedel–Crafts cyclization which forms the C ring of the natural product. Despite the synthetic advances achieved so far, we consider that a more efficient synthetic procedures could be carried out, since their synthetic routes are difficult to scale up due to numerous reaction steps and the limitations imposed by the use of some reagents. In this article, we present a new and versatile retrosynthetic analysis of (−)-pelorol and analogs, which is highly desirable for their easy preparation and subsequent broad study of their biological activities. This is a retrosynthetic route that could improve those reported in the literature in terms of cost-effectiveness.https://www.mdpi.com/1660-3397/22/9/425marine natural productsmeroterpenoidspelorol |
| spellingShingle | Antonio Rosales Martínez Ignacio Rodríguez-García Synthesis of Marine (−)-Pelorol and Future Perspectives Marine Drugs marine natural products meroterpenoids pelorol |
| title | Synthesis of Marine (−)-Pelorol and Future Perspectives |
| title_full | Synthesis of Marine (−)-Pelorol and Future Perspectives |
| title_fullStr | Synthesis of Marine (−)-Pelorol and Future Perspectives |
| title_full_unstemmed | Synthesis of Marine (−)-Pelorol and Future Perspectives |
| title_short | Synthesis of Marine (−)-Pelorol and Future Perspectives |
| title_sort | synthesis of marine pelorol and future perspectives |
| topic | marine natural products meroterpenoids pelorol |
| url | https://www.mdpi.com/1660-3397/22/9/425 |
| work_keys_str_mv | AT antoniorosalesmartinez synthesisofmarinepelorolandfutureperspectives AT ignaciorodriguezgarcia synthesisofmarinepelorolandfutureperspectives |