Intrauterine Growth Restriction and the Fetal Programming of the Hedonic Response to Sweet Taste in Newborn Infants
Intrauterine growth restriction is associated with increased risk for adult metabolic syndrome and cardiovascular disease, which seems to be related to altered food preferences in these individuals later in life. In this study, we sought to understand whether intrauterine growth leads to fetal progr...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2012/657379 |
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| author | Caroline Ayres Marilyn Agranonik André Krumel Portella Françoise Filion Celeste C. Johnston Patrícia Pelufo Silveira |
| author_facet | Caroline Ayres Marilyn Agranonik André Krumel Portella Françoise Filion Celeste C. Johnston Patrícia Pelufo Silveira |
| author_sort | Caroline Ayres |
| collection | DOAJ |
| description | Intrauterine growth restriction is associated with increased risk for adult metabolic syndrome and cardiovascular disease, which seems to be related to altered food preferences in these individuals later in life. In this study, we sought to understand whether intrauterine growth leads to fetal programming of the hedonic responses to sweet. Sixteen 1-day-old preterm infants received 24% sucrose solution or water and the taste reactivity was filmed and analyzed. Spearman correlation demonstrated a positive correlation between fetal growth and the hedonic response to the sweet solution in the first 15 seconds after the offer (r=0.864, P=0.001), without correlation when the solution given is water (r=0.314, P=0.455). In fact, the more intense the intrauterine growth restriction, the lower the frequency of the hedonic response observed. IUGR is strongly correlated with the hedonic response to a sweet solution in the first day of life in preterm infants. This is the first evidence in humans to demonstrate that the hedonic response to sweet taste is programmed very early during the fetal life by the degree of intrauterine growth. The altered hedonic response at birth and subsequent differential food preference may contribute to the increased risk of obesity and related disorders in adulthood in intrauterine growth-restricted individuals. |
| format | Article |
| id | doaj-art-25b7903fc0ca4c4c968deb00a2eedd3b |
| institution | OA Journals |
| issn | 1687-9740 1687-9759 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Pediatrics |
| spelling | doaj-art-25b7903fc0ca4c4c968deb00a2eedd3b2025-08-20T02:04:30ZengWileyInternational Journal of Pediatrics1687-97401687-97592012-01-01201210.1155/2012/657379657379Intrauterine Growth Restriction and the Fetal Programming of the Hedonic Response to Sweet Taste in Newborn InfantsCaroline Ayres0Marilyn Agranonik1André Krumel Portella2Françoise Filion3Celeste C. Johnston4Patrícia Pelufo Silveira5Núcleo de Estudos da Saúde da Criança e do Adolescente, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2350, 90035-903 Porto Alegre, RS, BrazilNúcleo de Estudos da Saúde da Criança e do Adolescente, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2350, 90035-903 Porto Alegre, RS, BrazilNúcleo de Estudos da Saúde da Criança e do Adolescente, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2350, 90035-903 Porto Alegre, RS, BrazilSchool of Nursing, McGill University, Montreal, QC, 43A 2A7, CanadaSchool of Nursing, McGill University, Montreal, QC, 43A 2A7, CanadaNúcleo de Estudos da Saúde da Criança e do Adolescente, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2350, 90035-903 Porto Alegre, RS, BrazilIntrauterine growth restriction is associated with increased risk for adult metabolic syndrome and cardiovascular disease, which seems to be related to altered food preferences in these individuals later in life. In this study, we sought to understand whether intrauterine growth leads to fetal programming of the hedonic responses to sweet. Sixteen 1-day-old preterm infants received 24% sucrose solution or water and the taste reactivity was filmed and analyzed. Spearman correlation demonstrated a positive correlation between fetal growth and the hedonic response to the sweet solution in the first 15 seconds after the offer (r=0.864, P=0.001), without correlation when the solution given is water (r=0.314, P=0.455). In fact, the more intense the intrauterine growth restriction, the lower the frequency of the hedonic response observed. IUGR is strongly correlated with the hedonic response to a sweet solution in the first day of life in preterm infants. This is the first evidence in humans to demonstrate that the hedonic response to sweet taste is programmed very early during the fetal life by the degree of intrauterine growth. The altered hedonic response at birth and subsequent differential food preference may contribute to the increased risk of obesity and related disorders in adulthood in intrauterine growth-restricted individuals.http://dx.doi.org/10.1155/2012/657379 |
| spellingShingle | Caroline Ayres Marilyn Agranonik André Krumel Portella Françoise Filion Celeste C. Johnston Patrícia Pelufo Silveira Intrauterine Growth Restriction and the Fetal Programming of the Hedonic Response to Sweet Taste in Newborn Infants International Journal of Pediatrics |
| title | Intrauterine Growth Restriction and the Fetal Programming of the Hedonic Response to Sweet Taste in Newborn Infants |
| title_full | Intrauterine Growth Restriction and the Fetal Programming of the Hedonic Response to Sweet Taste in Newborn Infants |
| title_fullStr | Intrauterine Growth Restriction and the Fetal Programming of the Hedonic Response to Sweet Taste in Newborn Infants |
| title_full_unstemmed | Intrauterine Growth Restriction and the Fetal Programming of the Hedonic Response to Sweet Taste in Newborn Infants |
| title_short | Intrauterine Growth Restriction and the Fetal Programming of the Hedonic Response to Sweet Taste in Newborn Infants |
| title_sort | intrauterine growth restriction and the fetal programming of the hedonic response to sweet taste in newborn infants |
| url | http://dx.doi.org/10.1155/2012/657379 |
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