Development of a live cell assay for real-time monitoring the interactions between the Hippo pathway components 14-3-3 and TAZ

Development of a live cell assay for real-time monitoring the interactions between the Hippo pathway components 14-3-3 and TAZ

The Hippo pathway plays an important role in organ size control and tissue homeostasis. Dysregulation is involved in many pathologies, including cancer, which has attracted interest in targeting the Hippo pathway. Since the upstream components are bona fide tumor suppressors, it is feasible to targe...

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Bibliographic Details
Main Authors: Blaž Andlovic, Alexander Wolf, Malgorzata Hiltmann, Bert M. Klebl, Jan Eickhoff, Christian Ottmann
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:SLAS Discovery
Subjects:
Cell-based assay
Protein-protein interactions
Split-luciferase complementation
Hippo pathway
Compound screening
Online Access:http://www.sciencedirect.com/science/article/pii/S2472555224000534
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