Role of Neutrophils in Psoriasis
Psoriasis is a common inflammatory disease that can involve the skin, joints, or both. The abnormalities of innate immunity play crucial roles in the pathogenesis of psoriasis. Neutrophils are the most abundant leukocytes in the circulation. Emerging evidences have demonstrated that neutrophils may...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2020/3709749 |
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| _version_ | 1832554988290703360 |
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| author | Wen-Ming Wang Hong-Zhong Jin |
| author_facet | Wen-Ming Wang Hong-Zhong Jin |
| author_sort | Wen-Ming Wang |
| collection | DOAJ |
| description | Psoriasis is a common inflammatory disease that can involve the skin, joints, or both. The abnormalities of innate immunity play crucial roles in the pathogenesis of psoriasis. Neutrophils are the most abundant leukocytes in the circulation. Emerging evidences have demonstrated that neutrophils may play a role in autoimmune diseases. The neutrophil-to-lymphocyte ratio (NLR), the activity of neutrophils, and the number of NETotic cells were significantly higher in psoriasis patients compared to healthy controls. The number of low-density granulocytes (LDGs) in the blood of psoriasis patients was significantly higher than those in the control blood. Furthermore, neutrophils may play important roles in the cardiovascular risk in psoriasis. However, the exact role of neutrophils in psoriasis remains unclear. In this review, we highlight the role of neutrophils in the pathogenesis of psoriasis. |
| format | Article |
| id | doaj-art-259c29386a0e4448b0cdb0b591dc0117 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-259c29386a0e4448b0cdb0b591dc01172025-02-03T05:49:54ZengWileyJournal of Immunology Research2314-88612314-71562020-01-01202010.1155/2020/37097493709749Role of Neutrophils in PsoriasisWen-Ming Wang0Hong-Zhong Jin1Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaPsoriasis is a common inflammatory disease that can involve the skin, joints, or both. The abnormalities of innate immunity play crucial roles in the pathogenesis of psoriasis. Neutrophils are the most abundant leukocytes in the circulation. Emerging evidences have demonstrated that neutrophils may play a role in autoimmune diseases. The neutrophil-to-lymphocyte ratio (NLR), the activity of neutrophils, and the number of NETotic cells were significantly higher in psoriasis patients compared to healthy controls. The number of low-density granulocytes (LDGs) in the blood of psoriasis patients was significantly higher than those in the control blood. Furthermore, neutrophils may play important roles in the cardiovascular risk in psoriasis. However, the exact role of neutrophils in psoriasis remains unclear. In this review, we highlight the role of neutrophils in the pathogenesis of psoriasis.http://dx.doi.org/10.1155/2020/3709749 |
| spellingShingle | Wen-Ming Wang Hong-Zhong Jin Role of Neutrophils in Psoriasis Journal of Immunology Research |
| title | Role of Neutrophils in Psoriasis |
| title_full | Role of Neutrophils in Psoriasis |
| title_fullStr | Role of Neutrophils in Psoriasis |
| title_full_unstemmed | Role of Neutrophils in Psoriasis |
| title_short | Role of Neutrophils in Psoriasis |
| title_sort | role of neutrophils in psoriasis |
| url | http://dx.doi.org/10.1155/2020/3709749 |
| work_keys_str_mv | AT wenmingwang roleofneutrophilsinpsoriasis AT hongzhongjin roleofneutrophilsinpsoriasis |