Salivary Biomarkers: Noninvasive Ways for Diagnosis of Parkinson’s Disease
Finding reliable biomarkers has a crucial role in Parkinson’s disease (PD) assessments. Saliva is a bodily fluid, which might be used as a source of biomarkers for PD. Our article has reviewed several publications on salivary proteins in PD patients and their potential as biomarkers. We find out tha...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | Neurology Research International |
| Online Access: | http://dx.doi.org/10.1155/2023/3555418 |
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| _version_ | 1832547903029116928 |
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| author | Sanaz Salaramoli Hamid Reza Joshaghani Seyed Isaac Hashemy |
| author_facet | Sanaz Salaramoli Hamid Reza Joshaghani Seyed Isaac Hashemy |
| author_sort | Sanaz Salaramoli |
| collection | DOAJ |
| description | Finding reliable biomarkers has a crucial role in Parkinson’s disease (PD) assessments. Saliva is a bodily fluid, which might be used as a source of biomarkers for PD. Our article has reviewed several publications on salivary proteins in PD patients and their potential as biomarkers. We find out that α-Syn’s proportion in oligomeric form is higher in PD patients’ saliva, which is potent to use as a biomarker for PD. The salivary concentration of DJ-1 and alpha-amylase is lower in PD patients. Also, substance P level is more moderate in PD patients. Although salivary flow rate is decreased in PD patients, high levels of heme oxygenase and acetylcholinesterase might be used as noninvasive biomarkers. Salivary miRNAs (miR-153, miR-223, miR-874, and miR-145-3p) are novel diagnostic biomarkers that should be given more attention. |
| format | Article |
| id | doaj-art-259aa263eb024338bca54879e5007a40 |
| institution | Kabale University |
| issn | 2090-1860 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neurology Research International |
| spelling | doaj-art-259aa263eb024338bca54879e5007a402025-02-03T06:42:57ZengWileyNeurology Research International2090-18602023-01-01202310.1155/2023/3555418Salivary Biomarkers: Noninvasive Ways for Diagnosis of Parkinson’s DiseaseSanaz Salaramoli0Hamid Reza Joshaghani1Seyed Isaac Hashemy2Student Research CommitteeLaboratory Sciences Research CenterDepartment of Clinical BiochemistryFinding reliable biomarkers has a crucial role in Parkinson’s disease (PD) assessments. Saliva is a bodily fluid, which might be used as a source of biomarkers for PD. Our article has reviewed several publications on salivary proteins in PD patients and their potential as biomarkers. We find out that α-Syn’s proportion in oligomeric form is higher in PD patients’ saliva, which is potent to use as a biomarker for PD. The salivary concentration of DJ-1 and alpha-amylase is lower in PD patients. Also, substance P level is more moderate in PD patients. Although salivary flow rate is decreased in PD patients, high levels of heme oxygenase and acetylcholinesterase might be used as noninvasive biomarkers. Salivary miRNAs (miR-153, miR-223, miR-874, and miR-145-3p) are novel diagnostic biomarkers that should be given more attention.http://dx.doi.org/10.1155/2023/3555418 |
| spellingShingle | Sanaz Salaramoli Hamid Reza Joshaghani Seyed Isaac Hashemy Salivary Biomarkers: Noninvasive Ways for Diagnosis of Parkinson’s Disease Neurology Research International |
| title | Salivary Biomarkers: Noninvasive Ways for Diagnosis of Parkinson’s Disease |
| title_full | Salivary Biomarkers: Noninvasive Ways for Diagnosis of Parkinson’s Disease |
| title_fullStr | Salivary Biomarkers: Noninvasive Ways for Diagnosis of Parkinson’s Disease |
| title_full_unstemmed | Salivary Biomarkers: Noninvasive Ways for Diagnosis of Parkinson’s Disease |
| title_short | Salivary Biomarkers: Noninvasive Ways for Diagnosis of Parkinson’s Disease |
| title_sort | salivary biomarkers noninvasive ways for diagnosis of parkinson s disease |
| url | http://dx.doi.org/10.1155/2023/3555418 |
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