Cyclic Bicytopenia in a Patient with Shapiro Syndrome
Shapiro syndrome and periodic hypothermia have been reported approximately fifty times in the literature. Shapiro syndrome is defined as the constellation of periodic hypothermia and hyperhidrosis along with agenesis of the corpus callosum by Shapiro et al. in 1969. Periodic hypothermia is a more br...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2013/231713 |
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| author | Lindsey E. Roeker Vinay Gupta Wilson I. Gonsalves Alexandra P. Wolanskyj Naseema Gangat |
| author_facet | Lindsey E. Roeker Vinay Gupta Wilson I. Gonsalves Alexandra P. Wolanskyj Naseema Gangat |
| author_sort | Lindsey E. Roeker |
| collection | DOAJ |
| description | Shapiro syndrome and periodic hypothermia have been reported approximately fifty times in the literature. Shapiro syndrome is defined as the constellation of periodic hypothermia and hyperhidrosis along with agenesis of the corpus callosum by Shapiro et al. in 1969. Periodic hypothermia is a more broad diagnosis with a number of proposed mechanisms; it occurs in patients without structural brain abnormalities. Hematologic abnormalities beyond iron-deficiency anemia have not been documented in any of the reported cases of Shapiro syndrome or periodic hypothermia. Though accidental and therapeutic hypothermia have been associated with thrombocytopenia, this is, to our knowledge, the first reported case of periodic intrinsic hypothermia causing bicytopenia. In this report, we present the case of a patient with Shapiro syndrome who experienced cyclic bicytopenia mirroring hypothermic episodes. We address the differential diagnosis of bicytopenia, review the mechanisms proposed for cytopenias related to hypothermia, and propose possible mechanisms for the finding in this case. |
| format | Article |
| id | doaj-art-258c7ab64b1b4eccb1d7baf105458f44 |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-258c7ab64b1b4eccb1d7baf105458f442025-02-03T05:44:41ZengWileyCase Reports in Hematology2090-65602090-65792013-01-01201310.1155/2013/231713231713Cyclic Bicytopenia in a Patient with Shapiro SyndromeLindsey E. Roeker0Vinay Gupta1Wilson I. Gonsalves2Alexandra P. Wolanskyj3Naseema Gangat4Mayo Medical School, Mayo Clinic, Rochester, USADepartment of Hematology, Mayo Clinic, 200 1st Street SW, Rochester, MN 55905, USADepartment of Hematology, Mayo Clinic, 200 1st Street SW, Rochester, MN 55905, USAMayo Medical School, Mayo Clinic, Rochester, USADepartment of Hematology, Mayo Clinic, 200 1st Street SW, Rochester, MN 55905, USAShapiro syndrome and periodic hypothermia have been reported approximately fifty times in the literature. Shapiro syndrome is defined as the constellation of periodic hypothermia and hyperhidrosis along with agenesis of the corpus callosum by Shapiro et al. in 1969. Periodic hypothermia is a more broad diagnosis with a number of proposed mechanisms; it occurs in patients without structural brain abnormalities. Hematologic abnormalities beyond iron-deficiency anemia have not been documented in any of the reported cases of Shapiro syndrome or periodic hypothermia. Though accidental and therapeutic hypothermia have been associated with thrombocytopenia, this is, to our knowledge, the first reported case of periodic intrinsic hypothermia causing bicytopenia. In this report, we present the case of a patient with Shapiro syndrome who experienced cyclic bicytopenia mirroring hypothermic episodes. We address the differential diagnosis of bicytopenia, review the mechanisms proposed for cytopenias related to hypothermia, and propose possible mechanisms for the finding in this case.http://dx.doi.org/10.1155/2013/231713 |
| spellingShingle | Lindsey E. Roeker Vinay Gupta Wilson I. Gonsalves Alexandra P. Wolanskyj Naseema Gangat Cyclic Bicytopenia in a Patient with Shapiro Syndrome Case Reports in Hematology |
| title | Cyclic Bicytopenia in a Patient with Shapiro Syndrome |
| title_full | Cyclic Bicytopenia in a Patient with Shapiro Syndrome |
| title_fullStr | Cyclic Bicytopenia in a Patient with Shapiro Syndrome |
| title_full_unstemmed | Cyclic Bicytopenia in a Patient with Shapiro Syndrome |
| title_short | Cyclic Bicytopenia in a Patient with Shapiro Syndrome |
| title_sort | cyclic bicytopenia in a patient with shapiro syndrome |
| url | http://dx.doi.org/10.1155/2013/231713 |
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