Cytokines and Cytokine Profiles in Human Autoimmune Diseases and Animal Models of Autoimmunity
The precise pathomechanisms of human autoimmune diseases are still poorly understood. However, a deepened understanding of these is urgently needed to improve disease prevention and early detection and guide more specific treatment approaches. In recent years, many new genes and signalling pathways...
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2009/979258 |
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| author | Manfred Kunz Saleh M. Ibrahim |
| author_facet | Manfred Kunz Saleh M. Ibrahim |
| author_sort | Manfred Kunz |
| collection | DOAJ |
| description | The precise pathomechanisms of human autoimmune diseases are still poorly understood. However, a deepened understanding of these is urgently needed to improve disease prevention and early detection and guide more specific treatment approaches. In recent years, many new genes and signalling pathways involved in autoimmunity with often overlapping patterns between different disease entities have been detected. Major contributions were made by experiments using DNA microarray technology, which has been used for the analysis of gene expression patterns in chronic inflammatory and autoimmune diseases, among which were rheumatoid arthritis, systemic lupus erythematosus, psoriasis, systemic sclerosis, multiple sclerosis, and type-1 diabetes. In systemic lupus erythematosus, a so-called interferon signature has been identified. In psoriasis, researchers found a particular immune signalling cluster. Moreover the identification of a new subset of inflammatory T cells, so-called Th17 T cells, secreting interleukin (IL)-17 as one of their major cytokines and the identification of the IL-23/IL-17 axis of inflammation regulation, have significantly improved our understanding of autoimmune diseases. Since a plethora of new treatment approaches using antibodies or small molecule inhibitors specifically targeting cytokines, cellular receptors, or signalling mechanisms has emerged in recent years, more individualized treatment for affected patients may be within reach in the future. |
| format | Article |
| id | doaj-art-2576eafad0ea46e7a192f0ea823a4fdc |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-2576eafad0ea46e7a192f0ea823a4fdc2025-02-03T06:00:51ZengWileyMediators of Inflammation0962-93511466-18612009-01-01200910.1155/2009/979258979258Cytokines and Cytokine Profiles in Human Autoimmune Diseases and Animal Models of AutoimmunityManfred Kunz0Saleh M. Ibrahim1Comprehensive Center for Inflammation Medicine, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, GermanyComprehensive Center for Inflammation Medicine, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, GermanyThe precise pathomechanisms of human autoimmune diseases are still poorly understood. However, a deepened understanding of these is urgently needed to improve disease prevention and early detection and guide more specific treatment approaches. In recent years, many new genes and signalling pathways involved in autoimmunity with often overlapping patterns between different disease entities have been detected. Major contributions were made by experiments using DNA microarray technology, which has been used for the analysis of gene expression patterns in chronic inflammatory and autoimmune diseases, among which were rheumatoid arthritis, systemic lupus erythematosus, psoriasis, systemic sclerosis, multiple sclerosis, and type-1 diabetes. In systemic lupus erythematosus, a so-called interferon signature has been identified. In psoriasis, researchers found a particular immune signalling cluster. Moreover the identification of a new subset of inflammatory T cells, so-called Th17 T cells, secreting interleukin (IL)-17 as one of their major cytokines and the identification of the IL-23/IL-17 axis of inflammation regulation, have significantly improved our understanding of autoimmune diseases. Since a plethora of new treatment approaches using antibodies or small molecule inhibitors specifically targeting cytokines, cellular receptors, or signalling mechanisms has emerged in recent years, more individualized treatment for affected patients may be within reach in the future.http://dx.doi.org/10.1155/2009/979258 |
| spellingShingle | Manfred Kunz Saleh M. Ibrahim Cytokines and Cytokine Profiles in Human Autoimmune Diseases and Animal Models of Autoimmunity Mediators of Inflammation |
| title | Cytokines and Cytokine Profiles in Human Autoimmune Diseases and Animal Models of Autoimmunity |
| title_full | Cytokines and Cytokine Profiles in Human Autoimmune Diseases and Animal Models of Autoimmunity |
| title_fullStr | Cytokines and Cytokine Profiles in Human Autoimmune Diseases and Animal Models of Autoimmunity |
| title_full_unstemmed | Cytokines and Cytokine Profiles in Human Autoimmune Diseases and Animal Models of Autoimmunity |
| title_short | Cytokines and Cytokine Profiles in Human Autoimmune Diseases and Animal Models of Autoimmunity |
| title_sort | cytokines and cytokine profiles in human autoimmune diseases and animal models of autoimmunity |
| url | http://dx.doi.org/10.1155/2009/979258 |
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