The Emerging Role of Mesenchymal Stem Cells in Vascular Calcification
Vascular calcification (VC), characterized by hydroxyapatite crystal depositing in the vessel wall, is a common pathological condition shared by many chronic diseases and an independent risk factor for cardiovascular events. Recently, VC is regarded as an active, dynamic cell-mediated process, durin...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2019/2875189 |
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| _version_ | 1832558086642991104 |
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| author | Changming Xie Liu Ouyang Jie Chen Huanji Zhang Pei Luo Jingfeng Wang Hui Huang |
| author_facet | Changming Xie Liu Ouyang Jie Chen Huanji Zhang Pei Luo Jingfeng Wang Hui Huang |
| author_sort | Changming Xie |
| collection | DOAJ |
| description | Vascular calcification (VC), characterized by hydroxyapatite crystal depositing in the vessel wall, is a common pathological condition shared by many chronic diseases and an independent risk factor for cardiovascular events. Recently, VC is regarded as an active, dynamic cell-mediated process, during which calcifying cell transition is critical. Mesenchymal stem cells (MSCs), with a multidirectional differentiation ability and great potential for clinical application, play a duplex role in the VC process. MSCs facilitate VC mainly through osteogenic transformation and apoptosis. Meanwhile, several studies have reported the protective role of MSCs. Anti-inflammation, blockade of the BMP2 signal, downregulation of the Wnt signal, and antiapoptosis through paracrine signaling are possible mechanisms. This review displays the evidence both on the facilitating role and on the protective role of MSCs, then discusses the key factors determining this divergence. |
| format | Article |
| id | doaj-art-256af8a3303b4c3093a15b7da083c27e |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-256af8a3303b4c3093a15b7da083c27e2025-02-03T01:33:16ZengWileyStem Cells International1687-966X1687-96782019-01-01201910.1155/2019/28751892875189The Emerging Role of Mesenchymal Stem Cells in Vascular CalcificationChangming Xie0Liu Ouyang1Jie Chen2Huanji Zhang3Pei Luo4Jingfeng Wang5Hui Huang6Department of Cardiology, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen 518000, ChinaGuangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Department of Cardiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, ChinaDepartment of Radiation Oncology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, ChinaDepartment of Cardiology, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen 518000, ChinaState Key Laboratory for Quality Research of Chinese Medicines, Macau University of Science and Technology, Taipa 999078, MacauGuangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Department of Cardiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, ChinaDepartment of Cardiology, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen 518000, ChinaVascular calcification (VC), characterized by hydroxyapatite crystal depositing in the vessel wall, is a common pathological condition shared by many chronic diseases and an independent risk factor for cardiovascular events. Recently, VC is regarded as an active, dynamic cell-mediated process, during which calcifying cell transition is critical. Mesenchymal stem cells (MSCs), with a multidirectional differentiation ability and great potential for clinical application, play a duplex role in the VC process. MSCs facilitate VC mainly through osteogenic transformation and apoptosis. Meanwhile, several studies have reported the protective role of MSCs. Anti-inflammation, blockade of the BMP2 signal, downregulation of the Wnt signal, and antiapoptosis through paracrine signaling are possible mechanisms. This review displays the evidence both on the facilitating role and on the protective role of MSCs, then discusses the key factors determining this divergence.http://dx.doi.org/10.1155/2019/2875189 |
| spellingShingle | Changming Xie Liu Ouyang Jie Chen Huanji Zhang Pei Luo Jingfeng Wang Hui Huang The Emerging Role of Mesenchymal Stem Cells in Vascular Calcification Stem Cells International |
| title | The Emerging Role of Mesenchymal Stem Cells in Vascular Calcification |
| title_full | The Emerging Role of Mesenchymal Stem Cells in Vascular Calcification |
| title_fullStr | The Emerging Role of Mesenchymal Stem Cells in Vascular Calcification |
| title_full_unstemmed | The Emerging Role of Mesenchymal Stem Cells in Vascular Calcification |
| title_short | The Emerging Role of Mesenchymal Stem Cells in Vascular Calcification |
| title_sort | emerging role of mesenchymal stem cells in vascular calcification |
| url | http://dx.doi.org/10.1155/2019/2875189 |
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