In vitro Superoxide Production by Peripheral Neutrophils from Patients with Inflammatory Bowel Disease
Activated polymorphonuclear leucocytes, which are accumulated in inflammatory lesions of inflammatory bowel disease, produce tissue destructive, oxygen derived free radicals and other inflammatory mediators. The PMN superoxide production elicited by formyl-methionyl-leucyl-phenylalanine or the compl...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1994-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S0962935194000219 |
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| Summary: | Activated polymorphonuclear leucocytes, which are accumulated in
inflammatory lesions of inflammatory bowel disease, produce tissue
destructive, oxygen derived free radicals and other inflammatory
mediators. The PMN superoxide production elicited by
formyl-methionyl-leucyl-phenylalanine or the complement split
product 5a were compared in IBD and healthy volunteers.
Significantly reduced superoxide production was found in PMNs from
patients with Crohn's disease as compared to normal controls,
when fMLP or CSa were used as stimulants (p<0.001 and p<0.01, respectively), whereas no differences were found when
ulcerative colitis patients were compared to normal controls (p>0.05).
The enhanced oxygen derived free radical production
previously reported in active IBD, and especially in CD intestinal
lesions, may either be due to an accumulation of productive
phagocytes or to a change of the inflammatory profile of these cells
when migrating into intestinal lesions, possibly due to interaction
with other mediators (e.g. adhesion molecules and interleukins). |
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| ISSN: | 0962-9351 1466-1861 |