Structural insights into heterohexameric assembly of epilepsy-related ligand–receptor complex LGI1–ADAM22

Structural insights into heterohexameric assembly of epilepsy-related ligand–receptor complex LGI1–ADAM22

Leucine-rich glioma-inactivated 1 protein (LGI1) is a secreted neuronal protein consisting of the N-terminal leucine-rich repeat (LRR) and C-terminal epitempin-repeat (EPTP) domains. LGI1 is linked to epilepsy, a neurological disorder that can be caused by genetic mutations of genes regulating neuro...

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Bibliographic Details
Main Authors: Takayuki Yamaguchi, Kei Okatsu, Masato Kubota, Ayuka Mitsumori, Atsushi Yamagata, Yuko Fukata, Masaki Fukata, Mikihiro Shibata, Shuya Fukai
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-07-01
Series:eLife
Subjects:
cryo-EM
HS-AFM
epilepsy
LGI1
ADAM22
assembly
Online Access:https://elifesciences.org/articles/105918
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