Diagnostic value of circulating chromogranin a for neuroendocrine tumors: a systematic review and meta-analysis.
<h4>Background</h4>In previous decades, chromogranin A (CgA) has been demonstrated to be the most promising biomarker for the diagnosis of neuroendocrine tumors (NETs), but its diagnostic value is still controversial. This meta-analysis aimed to estimate the potential diagnostic value of...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0124884 |
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| author | Xin Yang Yuan Yang Zhilu Li Chen Cheng Ting Yang Cheng Wang Lin Liu Shengchun Liu |
| author_facet | Xin Yang Yuan Yang Zhilu Li Chen Cheng Ting Yang Cheng Wang Lin Liu Shengchun Liu |
| author_sort | Xin Yang |
| collection | DOAJ |
| description | <h4>Background</h4>In previous decades, chromogranin A (CgA) has been demonstrated to be the most promising biomarker for the diagnosis of neuroendocrine tumors (NETs), but its diagnostic value is still controversial. This meta-analysis aimed to estimate the potential diagnostic value of circulating CgA for NETs.<h4>Methods</h4>We collected relevant studies from several electronic databases as well as from reference lists. Diagnostic indices of CgA were pooled with random effects models. Pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR) and summary receiver operating characteristic (SROC) curves for the diagnosis of NETs were used to estimate the overall diagnostic efficiency.<h4>Results</h4>Through a search strategy, 13 studies met the inclusion criteria and were included. These studies contained 1260 patients with NETs and 967 healthy controls in the total sample. As a result, the overall sensitivity, specificity and diagnostic odds ratio (DOR) were 0.73 (95% CI: 0.71 to 0.76), 0.95 (95% CI: 0.93 to 0.96) and 56.29 (95% CI: 25.27 to 125.38), respectively, while the summary positive likelihood ratio (PLR) and negative likelihood ratio (NLR) were 14.56 (95% CI: 6.62 to 32.02) and 0.26 (95% CI: 0.18 to 0.38), respectively. In addition, the area under the curve (AUC) of the circulating CgA in the diagnosis of NETs was 0.8962.<h4>Conclusions</h4>These data demonstrate that circulating CgA is an efficient biomarker for the diagnosis of NETs with high sensitivity and specificity, which indicates that it may be helpful for the clinical management of NETs. However, further studies are needed to clarify this issue. |
| format | Article |
| id | doaj-art-2538370ad0044b7f83473f06e008f8e8 |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-2538370ad0044b7f83473f06e008f8e82025-08-20T02:37:06ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01104e012488410.1371/journal.pone.0124884Diagnostic value of circulating chromogranin a for neuroendocrine tumors: a systematic review and meta-analysis.Xin YangYuan YangZhilu LiChen ChengTing YangCheng WangLin LiuShengchun Liu<h4>Background</h4>In previous decades, chromogranin A (CgA) has been demonstrated to be the most promising biomarker for the diagnosis of neuroendocrine tumors (NETs), but its diagnostic value is still controversial. This meta-analysis aimed to estimate the potential diagnostic value of circulating CgA for NETs.<h4>Methods</h4>We collected relevant studies from several electronic databases as well as from reference lists. Diagnostic indices of CgA were pooled with random effects models. Pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR) and summary receiver operating characteristic (SROC) curves for the diagnosis of NETs were used to estimate the overall diagnostic efficiency.<h4>Results</h4>Through a search strategy, 13 studies met the inclusion criteria and were included. These studies contained 1260 patients with NETs and 967 healthy controls in the total sample. As a result, the overall sensitivity, specificity and diagnostic odds ratio (DOR) were 0.73 (95% CI: 0.71 to 0.76), 0.95 (95% CI: 0.93 to 0.96) and 56.29 (95% CI: 25.27 to 125.38), respectively, while the summary positive likelihood ratio (PLR) and negative likelihood ratio (NLR) were 14.56 (95% CI: 6.62 to 32.02) and 0.26 (95% CI: 0.18 to 0.38), respectively. In addition, the area under the curve (AUC) of the circulating CgA in the diagnosis of NETs was 0.8962.<h4>Conclusions</h4>These data demonstrate that circulating CgA is an efficient biomarker for the diagnosis of NETs with high sensitivity and specificity, which indicates that it may be helpful for the clinical management of NETs. However, further studies are needed to clarify this issue.https://doi.org/10.1371/journal.pone.0124884 |
| spellingShingle | Xin Yang Yuan Yang Zhilu Li Chen Cheng Ting Yang Cheng Wang Lin Liu Shengchun Liu Diagnostic value of circulating chromogranin a for neuroendocrine tumors: a systematic review and meta-analysis. PLoS ONE |
| title | Diagnostic value of circulating chromogranin a for neuroendocrine tumors: a systematic review and meta-analysis. |
| title_full | Diagnostic value of circulating chromogranin a for neuroendocrine tumors: a systematic review and meta-analysis. |
| title_fullStr | Diagnostic value of circulating chromogranin a for neuroendocrine tumors: a systematic review and meta-analysis. |
| title_full_unstemmed | Diagnostic value of circulating chromogranin a for neuroendocrine tumors: a systematic review and meta-analysis. |
| title_short | Diagnostic value of circulating chromogranin a for neuroendocrine tumors: a systematic review and meta-analysis. |
| title_sort | diagnostic value of circulating chromogranin a for neuroendocrine tumors a systematic review and meta analysis |
| url | https://doi.org/10.1371/journal.pone.0124884 |
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