Preclinical Polymodal Hallucinations for 13 Years before Dementia with Lewy Bodies
Objective. We describe a case of dementia with Lewy bodies (DLB) that presented long-lasting preclinical complex polymodal hallucinations. Background. Few studies have deeply investigated the characteristics of hallucinations in DLB, especially in the preclinical phase. Moreover, the clinical phenot...
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Wiley
2014-01-01
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| Series: | Behavioural Neurology |
| Online Access: | http://dx.doi.org/10.1155/2014/694296 |
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| author | Carlo Abbate Pietro Davide Trimarchi Silvia Inglese Niccolò Viti Alessandra Cantatore Lisa De Agostini Federico Pirri Lorenza Marino Renzo Bagarolo Daniela Mari |
| author_facet | Carlo Abbate Pietro Davide Trimarchi Silvia Inglese Niccolò Viti Alessandra Cantatore Lisa De Agostini Federico Pirri Lorenza Marino Renzo Bagarolo Daniela Mari |
| author_sort | Carlo Abbate |
| collection | DOAJ |
| description | Objective. We describe a case of dementia with Lewy bodies (DLB) that presented long-lasting preclinical complex polymodal hallucinations. Background. Few studies have deeply investigated the characteristics of hallucinations in DLB, especially in the preclinical phase. Moreover, the clinical phenotype of mild cognitive impairment-(MCI-) DLB is poorly understood. Methods. The patient was followed for 4 years and a selective phenomenological and cognitive study was performed at the predementia stage. Results. The phenomenological study showed the presence of hypnagogic and hypnopompic hallucinations that allowed us to make a differential diagnosis between DLB and Charles Bonnet syndrome (CBS). The neuropsychological evaluation showed a multiple domain without amnesia MCI subtype with prefrontal dysexecutive, visuoperceptual, and visuospatial impairments and simultanagnosia, which has not previously been reported in MCI-DLB. Conclusions. This study extends the prognostic value of hallucinations for DLB to the preclinical phases. It supports and refines the MCI-DLB concept and identifies simultanagnosia as a possible early cognitive marker. Finally, it confirms an association between hallucinations and visuoperceptual impairments at an intermediate stage of the disease course and strongly supports the hypothesis that hallucinations in the earliest stages of DLB may reflect a narcolepsy-like REM-sleep disorder. |
| format | Article |
| id | doaj-art-25349089a4a4423291cd489de0d85798 |
| institution | Kabale University |
| issn | 0953-4180 1875-8584 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Behavioural Neurology |
| spelling | doaj-art-25349089a4a4423291cd489de0d857982025-02-03T01:28:09ZengWileyBehavioural Neurology0953-41801875-85842014-01-01201410.1155/2014/694296694296Preclinical Polymodal Hallucinations for 13 Years before Dementia with Lewy BodiesCarlo Abbate0Pietro Davide Trimarchi1Silvia Inglese2Niccolò Viti3Alessandra Cantatore4Lisa De Agostini5Federico Pirri6Lorenza Marino7Renzo Bagarolo8Daniela Mari9Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, Unità Operativa Complessa di Geriatria, Via Pace 9, 20122 Milan, ItalyFondazione IRCCS Don Carlo Gnocchi, ONLUS, S. Maria Nascente, Via Capecelatro 66, 20148 Milan, ItalyFondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, Unità Operativa Complessa di Geriatria, Via Pace 9, 20122 Milan, ItalyFondazione IRCCS Don Carlo Gnocchi, ONLUS, S. Maria Nascente, Via Capecelatro 66, 20148 Milan, ItalyFondazione IRCCS Don Carlo Gnocchi, ONLUS, S. Maria Nascente, Via Capecelatro 66, 20148 Milan, ItalyFondazione IRCCS Don Carlo Gnocchi, ONLUS, S. Maria Nascente, Via Capecelatro 66, 20148 Milan, ItalyFondazione IRCCS Don Carlo Gnocchi, ONLUS, S. Maria Nascente, Via Capecelatro 66, 20148 Milan, ItalyFondazione IRCCS Don Carlo Gnocchi, ONLUS, S. Maria Nascente, Via Capecelatro 66, 20148 Milan, ItalyFondazione IRCCS Don Carlo Gnocchi, ONLUS, S. Maria Nascente, Via Capecelatro 66, 20148 Milan, ItalyFondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, Unità Operativa Complessa di Geriatria, Via Pace 9, 20122 Milan, ItalyObjective. We describe a case of dementia with Lewy bodies (DLB) that presented long-lasting preclinical complex polymodal hallucinations. Background. Few studies have deeply investigated the characteristics of hallucinations in DLB, especially in the preclinical phase. Moreover, the clinical phenotype of mild cognitive impairment-(MCI-) DLB is poorly understood. Methods. The patient was followed for 4 years and a selective phenomenological and cognitive study was performed at the predementia stage. Results. The phenomenological study showed the presence of hypnagogic and hypnopompic hallucinations that allowed us to make a differential diagnosis between DLB and Charles Bonnet syndrome (CBS). The neuropsychological evaluation showed a multiple domain without amnesia MCI subtype with prefrontal dysexecutive, visuoperceptual, and visuospatial impairments and simultanagnosia, which has not previously been reported in MCI-DLB. Conclusions. This study extends the prognostic value of hallucinations for DLB to the preclinical phases. It supports and refines the MCI-DLB concept and identifies simultanagnosia as a possible early cognitive marker. Finally, it confirms an association between hallucinations and visuoperceptual impairments at an intermediate stage of the disease course and strongly supports the hypothesis that hallucinations in the earliest stages of DLB may reflect a narcolepsy-like REM-sleep disorder.http://dx.doi.org/10.1155/2014/694296 |
| spellingShingle | Carlo Abbate Pietro Davide Trimarchi Silvia Inglese Niccolò Viti Alessandra Cantatore Lisa De Agostini Federico Pirri Lorenza Marino Renzo Bagarolo Daniela Mari Preclinical Polymodal Hallucinations for 13 Years before Dementia with Lewy Bodies Behavioural Neurology |
| title | Preclinical Polymodal Hallucinations for 13 Years before Dementia with Lewy Bodies |
| title_full | Preclinical Polymodal Hallucinations for 13 Years before Dementia with Lewy Bodies |
| title_fullStr | Preclinical Polymodal Hallucinations for 13 Years before Dementia with Lewy Bodies |
| title_full_unstemmed | Preclinical Polymodal Hallucinations for 13 Years before Dementia with Lewy Bodies |
| title_short | Preclinical Polymodal Hallucinations for 13 Years before Dementia with Lewy Bodies |
| title_sort | preclinical polymodal hallucinations for 13 years before dementia with lewy bodies |
| url | http://dx.doi.org/10.1155/2014/694296 |
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