Doxycycline Degradation by the Oxidative Fenton Process
Doxycycline is a broad-spectrum tetracycline occurring in domestic, industrial, and rural effluents, whose main drawback is the increasing emergence of resistant bacteria. This antibiotic could be degraded by the so-called Fenton process, consisting in the oxidation of organic pollutants by oxygen p...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2015/492030 |
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| author | Alexandre A. Borghi Milena F. Silva Saleh Al Arni Attilio Converti Mauri S. A. Palma |
| author_facet | Alexandre A. Borghi Milena F. Silva Saleh Al Arni Attilio Converti Mauri S. A. Palma |
| author_sort | Alexandre A. Borghi |
| collection | DOAJ |
| description | Doxycycline is a broad-spectrum tetracycline occurring in domestic, industrial, and rural effluents, whose main drawback is the increasing emergence of resistant bacteria. This antibiotic could be degraded by the so-called Fenton process, consisting in the oxidation of organic pollutants by oxygen peroxide (H2O2) in the presence of Fe2+. Experiments were performed according to an experimental Rotational Central Composite Design to investigate the influence of temperature (0–40.0°C), H2O2 concentration (100–900 mg/L), and Fe2+ concentration (5–120 mg/L) on residual doxycycline and total organic carbon concentrations. Whereas the final residual doxycycline concentration ranged from 0 to 55.8 mg/L, the oxidation process proved unable to reduce the total organic carbon by more than 30%. The best operating conditions were concentrations of H2O2 and Fe2+ of 611 and 25 mg/L, respectively, and temperature of 35.0°C, but the analysis of variance revealed that only the first variable exerted a statistically significant effect on the residual doxycycline concentration. These results suggest possible application of this process in the treatment of doxycycline-containing effluents and may be used as starting basis to treat tetracycline-contaminated effluents. |
| format | Article |
| id | doaj-art-252c5cc82de843bb8ba1c94ff9ac8013 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-252c5cc82de843bb8ba1c94ff9ac80132025-02-03T01:01:45ZengWileyJournal of Chemistry2090-90632090-90712015-01-01201510.1155/2015/492030492030Doxycycline Degradation by the Oxidative Fenton ProcessAlexandre A. Borghi0Milena F. Silva1Saleh Al Arni2Attilio Converti3Mauri S. A. Palma4Department of Biochemical and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, University of São Paulo, Bloco 16, Avenida Prof. Lineu Prestes 580, 05508-000 São Paulo, SP, BrazilBiological Science Center, Federal University of Pernambuco, Avenue Prof. Moraes Rego 1235, Cidade Universitária, 50670-901 Recife, PE, BrazilDepartment of Chemical Engineering, King Saud University, P.O. Box 800, Riyadh 11421, Saudi ArabiaDepartment of Civil, Chemical and Environmental Engineering, Pole of Chemical Engineering, Genoa University, Via Opera Pia 15, 16145 Genoa, ItalyDepartment of Biochemical and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, University of São Paulo, Bloco 16, Avenida Prof. Lineu Prestes 580, 05508-000 São Paulo, SP, BrazilDoxycycline is a broad-spectrum tetracycline occurring in domestic, industrial, and rural effluents, whose main drawback is the increasing emergence of resistant bacteria. This antibiotic could be degraded by the so-called Fenton process, consisting in the oxidation of organic pollutants by oxygen peroxide (H2O2) in the presence of Fe2+. Experiments were performed according to an experimental Rotational Central Composite Design to investigate the influence of temperature (0–40.0°C), H2O2 concentration (100–900 mg/L), and Fe2+ concentration (5–120 mg/L) on residual doxycycline and total organic carbon concentrations. Whereas the final residual doxycycline concentration ranged from 0 to 55.8 mg/L, the oxidation process proved unable to reduce the total organic carbon by more than 30%. The best operating conditions were concentrations of H2O2 and Fe2+ of 611 and 25 mg/L, respectively, and temperature of 35.0°C, but the analysis of variance revealed that only the first variable exerted a statistically significant effect on the residual doxycycline concentration. These results suggest possible application of this process in the treatment of doxycycline-containing effluents and may be used as starting basis to treat tetracycline-contaminated effluents.http://dx.doi.org/10.1155/2015/492030 |
| spellingShingle | Alexandre A. Borghi Milena F. Silva Saleh Al Arni Attilio Converti Mauri S. A. Palma Doxycycline Degradation by the Oxidative Fenton Process Journal of Chemistry |
| title | Doxycycline Degradation by the Oxidative Fenton Process |
| title_full | Doxycycline Degradation by the Oxidative Fenton Process |
| title_fullStr | Doxycycline Degradation by the Oxidative Fenton Process |
| title_full_unstemmed | Doxycycline Degradation by the Oxidative Fenton Process |
| title_short | Doxycycline Degradation by the Oxidative Fenton Process |
| title_sort | doxycycline degradation by the oxidative fenton process |
| url | http://dx.doi.org/10.1155/2015/492030 |
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