Dynamics of pathological changes of myocardial structures of rats under administration of doxorubicin
Due to the high cardiotoxicity of doxorubicin it is used to study pathogenesis of heart failure. Aim. In order to study the dynamics of pathological changes of the heart in the experiment, ECG, pathological and histopathological changes in the myocardium were investigated in 60 rats with doxorubi...
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| Format: | Article |
| Language: | English |
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Zaporizhzhia State Medical and Pharmaceutical University
2015-04-01
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| Series: | Patologìâ |
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| Online Access: | http://pat.zsmu.edu.ua/article/view/42816/39220 |
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| author | А. G. Rodinskij Ju. V. Kozlova L. V. Guz' |
| author_facet | А. G. Rodinskij Ju. V. Kozlova L. V. Guz' |
| author_sort | А. G. Rodinskij |
| collection | DOAJ |
| description | Due to the high cardiotoxicity of doxorubicin it is used to study pathogenesis of heart failure.
Aim. In order to study the dynamics of pathological changes of the heart in the experiment, ECG, pathological and histopathological changes in the myocardium were investigated in 60 rats with doxorubicin cardiomyopathy and 60 rats in the control group.
Methods and results. We found that irreversible myocardial damage, established by us in the dynamics, namely destructive and degenerative changes of cardiomyocytes with the loss of their special characteristics, as a result of doxorubicin effect are not only local, but also diffuse, markers of which are the violation of the functional aspect of automaticity, conduction of the heart and rapidly progressive heart failure. |
| format | Article |
| id | doaj-art-250898a7d2364c4cbc4aa1cce9dabfb0 |
| institution | Kabale University |
| issn | 2306-8027 2310-1237 |
| language | English |
| publishDate | 2015-04-01 |
| publisher | Zaporizhzhia State Medical and Pharmaceutical University |
| record_format | Article |
| series | Patologìâ |
| spelling | doaj-art-250898a7d2364c4cbc4aa1cce9dabfb02025-08-20T03:54:52ZengZaporizhzhia State Medical and Pharmaceutical UniversityPatologìâ2306-80272310-12372015-04-01181110.14739/2310-1237.2015.1.42816Dynamics of pathological changes of myocardial structures of rats under administration of doxorubicinА. G. RodinskijJu. V. KozlovaL. V. Guz'Due to the high cardiotoxicity of doxorubicin it is used to study pathogenesis of heart failure. Aim. In order to study the dynamics of pathological changes of the heart in the experiment, ECG, pathological and histopathological changes in the myocardium were investigated in 60 rats with doxorubicin cardiomyopathy and 60 rats in the control group. Methods and results. We found that irreversible myocardial damage, established by us in the dynamics, namely destructive and degenerative changes of cardiomyocytes with the loss of their special characteristics, as a result of doxorubicin effect are not only local, but also diffuse, markers of which are the violation of the functional aspect of automaticity, conduction of the heart and rapidly progressive heart failure.http://pat.zsmu.edu.ua/article/view/42816/39220DoxorubicinMyocardiumRats |
| spellingShingle | А. G. Rodinskij Ju. V. Kozlova L. V. Guz' Dynamics of pathological changes of myocardial structures of rats under administration of doxorubicin Patologìâ Doxorubicin Myocardium Rats |
| title | Dynamics of pathological changes of myocardial structures of rats under administration of doxorubicin |
| title_full | Dynamics of pathological changes of myocardial structures of rats under administration of doxorubicin |
| title_fullStr | Dynamics of pathological changes of myocardial structures of rats under administration of doxorubicin |
| title_full_unstemmed | Dynamics of pathological changes of myocardial structures of rats under administration of doxorubicin |
| title_short | Dynamics of pathological changes of myocardial structures of rats under administration of doxorubicin |
| title_sort | dynamics of pathological changes of myocardial structures of rats under administration of doxorubicin |
| topic | Doxorubicin Myocardium Rats |
| url | http://pat.zsmu.edu.ua/article/view/42816/39220 |
| work_keys_str_mv | AT agrodinskij dynamicsofpathologicalchangesofmyocardialstructuresofratsunderadministrationofdoxorubicin AT juvkozlova dynamicsofpathologicalchangesofmyocardialstructuresofratsunderadministrationofdoxorubicin AT lvguz dynamicsofpathologicalchangesofmyocardialstructuresofratsunderadministrationofdoxorubicin |