Association of Insomnia, Lipid Profile, and Lipid-Lowering Medications: A Narrative Review
Sleep is a fundamental phenomenon that helps maintain normal physiological processes. Conversely, sleep disorders, usually presented as insomnia, are a common public health problem that can lead to multiple pathophysiological changes in humans, including lipid metabolic abnormality. Interestingly, s...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
IMR Press
2025-01-01
|
| Series: | Reviews in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/RCM/26/1/10.31083/RCM24978 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832586493495869440 |
|---|---|
| author | Fang Jia Shun-Yi Shi Si-Fan Fei Min Zhou Jian-Jun Li |
| author_facet | Fang Jia Shun-Yi Shi Si-Fan Fei Min Zhou Jian-Jun Li |
| author_sort | Fang Jia |
| collection | DOAJ |
| description | Sleep is a fundamental phenomenon that helps maintain normal physiological processes. Conversely, sleep disorders, usually presented as insomnia, are a common public health problem that can lead to multiple pathophysiological changes in humans, including lipid metabolic abnormality. Interestingly, several previous studies have examined the potential relation of insomnia to metabolic syndrome and hyperlipidemia and found that insomnia was associated with elevated plasma cholesterol and triglyceride concentrations. This review summarizes evidence regarding the linkage between insomnia and lipid abnormalities. Moreover, the underlying physiologic mechanisms linking insomnia to lipid abnormalities are systemically discussed. Finally, issues with lipid-lowering drugs and the risk of insomnia are also presented. This knowledge can improve our understanding of the pathophysiological features of insomnia, which may help to prevent and treat insomnia-induced dyslipidemia clinically. |
| format | Article |
| id | doaj-art-24fecf7d512046a3a6dd03b46e277bfd |
| institution | Kabale University |
| issn | 1530-6550 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Reviews in Cardiovascular Medicine |
| spelling | doaj-art-24fecf7d512046a3a6dd03b46e277bfd2025-01-25T10:41:19ZengIMR PressReviews in Cardiovascular Medicine1530-65502025-01-012612497810.31083/RCM24978S1530-6550(24)01590-4Association of Insomnia, Lipid Profile, and Lipid-Lowering Medications: A Narrative ReviewFang Jia0Shun-Yi Shi1Si-Fan Fei2Min Zhou3Jian-Jun Li4Department of Cardiology, The Third Affiliated Hospital of Soochow University, 213003 Changzhou, Jiangsu, ChinaDepartment of Cardiology, The Third Affiliated Hospital of Soochow University, 213003 Changzhou, Jiangsu, ChinaDepartment of Cardiology, The Third Affiliated Hospital of Soochow University, 213003 Changzhou, Jiangsu, ChinaDepartment of Cardiology, The Third Affiliated Hospital of Soochow University, 213003 Changzhou, Jiangsu, ChinaCardio-Metabolic Center, Fu Wai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, 10037 Beijing, ChinaSleep is a fundamental phenomenon that helps maintain normal physiological processes. Conversely, sleep disorders, usually presented as insomnia, are a common public health problem that can lead to multiple pathophysiological changes in humans, including lipid metabolic abnormality. Interestingly, several previous studies have examined the potential relation of insomnia to metabolic syndrome and hyperlipidemia and found that insomnia was associated with elevated plasma cholesterol and triglyceride concentrations. This review summarizes evidence regarding the linkage between insomnia and lipid abnormalities. Moreover, the underlying physiologic mechanisms linking insomnia to lipid abnormalities are systemically discussed. Finally, issues with lipid-lowering drugs and the risk of insomnia are also presented. This knowledge can improve our understanding of the pathophysiological features of insomnia, which may help to prevent and treat insomnia-induced dyslipidemia clinically.https://www.imrpress.com/journal/RCM/26/1/10.31083/RCM24978insomnialipid metabolismcoronary artery diseasestatinproprotein convertase subtilisin/kexin type 9 inhibitors (pcsk9i) |
| spellingShingle | Fang Jia Shun-Yi Shi Si-Fan Fei Min Zhou Jian-Jun Li Association of Insomnia, Lipid Profile, and Lipid-Lowering Medications: A Narrative Review Reviews in Cardiovascular Medicine insomnia lipid metabolism coronary artery disease statin proprotein convertase subtilisin/kexin type 9 inhibitors (pcsk9i) |
| title | Association of Insomnia, Lipid Profile, and Lipid-Lowering Medications: A Narrative Review |
| title_full | Association of Insomnia, Lipid Profile, and Lipid-Lowering Medications: A Narrative Review |
| title_fullStr | Association of Insomnia, Lipid Profile, and Lipid-Lowering Medications: A Narrative Review |
| title_full_unstemmed | Association of Insomnia, Lipid Profile, and Lipid-Lowering Medications: A Narrative Review |
| title_short | Association of Insomnia, Lipid Profile, and Lipid-Lowering Medications: A Narrative Review |
| title_sort | association of insomnia lipid profile and lipid lowering medications a narrative review |
| topic | insomnia lipid metabolism coronary artery disease statin proprotein convertase subtilisin/kexin type 9 inhibitors (pcsk9i) |
| url | https://www.imrpress.com/journal/RCM/26/1/10.31083/RCM24978 |
| work_keys_str_mv | AT fangjia associationofinsomnialipidprofileandlipidloweringmedicationsanarrativereview AT shunyishi associationofinsomnialipidprofileandlipidloweringmedicationsanarrativereview AT sifanfei associationofinsomnialipidprofileandlipidloweringmedicationsanarrativereview AT minzhou associationofinsomnialipidprofileandlipidloweringmedicationsanarrativereview AT jianjunli associationofinsomnialipidprofileandlipidloweringmedicationsanarrativereview |