Genetic and Molecular Biology Implications in the Surgical Treatment of Gastric Cancer
Gastric cancer is one of the leading causes of death from neoplasms in the world. Current clinical practice guidelines offer treatment models that involve surgery, radiotherapy, chemotherapy, immunotherapy and therapy directed at specific growth receptors, however, genetic and molecular biology aspe...
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| Format: | Article |
| Language: | Spanish |
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Universidad de las Ciencias Médicas de Cienfuegos
2021-05-01
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| Series: | Revista Finlay |
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| Online Access: | https://revfinlay.sld.cu/index.php/finlay/article/view/952 |
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| author | Roberto Eduardo Aguirre Fernández Miguel Ángel Serra Valdés |
| author_facet | Roberto Eduardo Aguirre Fernández Miguel Ángel Serra Valdés |
| author_sort | Roberto Eduardo Aguirre Fernández |
| collection | DOAJ |
| description | Gastric cancer is one of the leading causes of death from neoplasms in the world. Current clinical practice guidelines offer treatment models that involve surgery, radiotherapy, chemotherapy, immunotherapy and therapy directed at specific growth receptors, however, genetic and molecular biology aspects are not always taken into account in medical practice. The objective of this review is to articulate the most relevant current aspects of genetics and molecular biology in relation to gastric cancer, to integrate them into the clinical guidelines of patients and relatives with the diagnosis or at risk of suffering from this type of neoplasia. For them, genetic advances and syndromes related to gastric cancer, molecular classifications and implications in their management were reviewed. The databases Google Scholar, Elsevier, and PubMed were used in the last 10 years, selecting the most important full-text from a qualitative point of view. The integration of personal and family history with genetic elements needs to be taken into account in the diagnostic management and prevention of this disease. The inclusion of genetic and molecular elements in all clinical practice guidelines is suggested. |
| format | Article |
| id | doaj-art-24f01ccb3459486780d16fe121f68c9f |
| institution | Kabale University |
| issn | 2221-2434 |
| language | Spanish |
| publishDate | 2021-05-01 |
| publisher | Universidad de las Ciencias Médicas de Cienfuegos |
| record_format | Article |
| series | Revista Finlay |
| spelling | doaj-art-24f01ccb3459486780d16fe121f68c9f2025-01-30T21:22:00ZspaUniversidad de las Ciencias Médicas de CienfuegosRevista Finlay2221-24342021-05-01112189199505Genetic and Molecular Biology Implications in the Surgical Treatment of Gastric CancerRoberto Eduardo Aguirre Fernández0Miguel Ángel Serra Valdés1Universidad Técnica de Machala. El Oro. Ecuador.Hospital General Docente Enrique Cabrera. La Habana.Gastric cancer is one of the leading causes of death from neoplasms in the world. Current clinical practice guidelines offer treatment models that involve surgery, radiotherapy, chemotherapy, immunotherapy and therapy directed at specific growth receptors, however, genetic and molecular biology aspects are not always taken into account in medical practice. The objective of this review is to articulate the most relevant current aspects of genetics and molecular biology in relation to gastric cancer, to integrate them into the clinical guidelines of patients and relatives with the diagnosis or at risk of suffering from this type of neoplasia. For them, genetic advances and syndromes related to gastric cancer, molecular classifications and implications in their management were reviewed. The databases Google Scholar, Elsevier, and PubMed were used in the last 10 years, selecting the most important full-text from a qualitative point of view. The integration of personal and family history with genetic elements needs to be taken into account in the diagnostic management and prevention of this disease. The inclusion of genetic and molecular elements in all clinical practice guidelines is suggested.https://revfinlay.sld.cu/index.php/finlay/article/view/952neoplasias gástricasprocedimientos quirúrgicos del sistema digestivoantecedentes genéticosbiología molecular |
| spellingShingle | Roberto Eduardo Aguirre Fernández Miguel Ángel Serra Valdés Genetic and Molecular Biology Implications in the Surgical Treatment of Gastric Cancer Revista Finlay neoplasias gástricas procedimientos quirúrgicos del sistema digestivo antecedentes genéticos biología molecular |
| title | Genetic and Molecular Biology Implications in the Surgical Treatment of Gastric Cancer |
| title_full | Genetic and Molecular Biology Implications in the Surgical Treatment of Gastric Cancer |
| title_fullStr | Genetic and Molecular Biology Implications in the Surgical Treatment of Gastric Cancer |
| title_full_unstemmed | Genetic and Molecular Biology Implications in the Surgical Treatment of Gastric Cancer |
| title_short | Genetic and Molecular Biology Implications in the Surgical Treatment of Gastric Cancer |
| title_sort | genetic and molecular biology implications in the surgical treatment of gastric cancer |
| topic | neoplasias gástricas procedimientos quirúrgicos del sistema digestivo antecedentes genéticos biología molecular |
| url | https://revfinlay.sld.cu/index.php/finlay/article/view/952 |
| work_keys_str_mv | AT robertoeduardoaguirrefernandez geneticandmolecularbiologyimplicationsinthesurgicaltreatmentofgastriccancer AT miguelangelserravaldes geneticandmolecularbiologyimplicationsinthesurgicaltreatmentofgastriccancer |