The Management of Classical Hodgkin's Lymphoma: Past, Present, and Future
The management of classical Hodgkin's lymphoma (CHL) is a success story of modern multi-agent haemato-oncology. Prior to the middle of the twentieth century CHL was fatal in the majority of cases. Introduction of single agent radiotherapy (RT) demonstrated for the first time that these patients...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Advances in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2011/865870 |
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| author | S. E. Richardson C. McNamara |
| author_facet | S. E. Richardson C. McNamara |
| author_sort | S. E. Richardson |
| collection | DOAJ |
| description | The management of classical Hodgkin's lymphoma (CHL) is a success story of modern multi-agent haemato-oncology. Prior to the middle of the twentieth century CHL was fatal in the majority of cases. Introduction of single agent radiotherapy (RT) demonstrated for the first time that these patients could be cured. Developments in chemotherapy including the mechlorethamine, vincristine, procarbazine and prednisolone (MOPP) and Adriamycin, bleomycin, vinblastine and dacarbazine (ABVD) regimens have resulted in cure rates of over 80%. Even in relapse, CHL patients can be salvaged with high dose chemotherapy and autologous haematopoietic stem cell transplantation (ASCT). Challenges remain, however, in finding new strategies to manage the small number of patients who continue to relapse or progress. In addition, the young age of many Hodgkin's patients forces difficult decisions in balancing the benefit of early disease control against the survival disadvantage of late toxicity. In this article we aim to summarise past trials, define the current standard of care and appraise future developments in the management of CHL. |
| format | Article |
| id | doaj-art-24e897ee534c4b92b585ef1c22bfd463 |
| institution | Kabale University |
| issn | 1687-9104 1687-9112 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Hematology |
| spelling | doaj-art-24e897ee534c4b92b585ef1c22bfd4632025-02-03T06:06:41ZengWileyAdvances in Hematology1687-91041687-91122011-01-01201110.1155/2011/865870865870The Management of Classical Hodgkin's Lymphoma: Past, Present, and FutureS. E. Richardson0C. McNamara1Department of Haematology, Royal Free Hospital, Pond Street, London NW3 2TB, UKDepartment of Haematology, Royal Free Hospital, Pond Street, London NW3 2TB, UKThe management of classical Hodgkin's lymphoma (CHL) is a success story of modern multi-agent haemato-oncology. Prior to the middle of the twentieth century CHL was fatal in the majority of cases. Introduction of single agent radiotherapy (RT) demonstrated for the first time that these patients could be cured. Developments in chemotherapy including the mechlorethamine, vincristine, procarbazine and prednisolone (MOPP) and Adriamycin, bleomycin, vinblastine and dacarbazine (ABVD) regimens have resulted in cure rates of over 80%. Even in relapse, CHL patients can be salvaged with high dose chemotherapy and autologous haematopoietic stem cell transplantation (ASCT). Challenges remain, however, in finding new strategies to manage the small number of patients who continue to relapse or progress. In addition, the young age of many Hodgkin's patients forces difficult decisions in balancing the benefit of early disease control against the survival disadvantage of late toxicity. In this article we aim to summarise past trials, define the current standard of care and appraise future developments in the management of CHL.http://dx.doi.org/10.1155/2011/865870 |
| spellingShingle | S. E. Richardson C. McNamara The Management of Classical Hodgkin's Lymphoma: Past, Present, and Future Advances in Hematology |
| title | The Management of Classical Hodgkin's Lymphoma: Past, Present, and Future |
| title_full | The Management of Classical Hodgkin's Lymphoma: Past, Present, and Future |
| title_fullStr | The Management of Classical Hodgkin's Lymphoma: Past, Present, and Future |
| title_full_unstemmed | The Management of Classical Hodgkin's Lymphoma: Past, Present, and Future |
| title_short | The Management of Classical Hodgkin's Lymphoma: Past, Present, and Future |
| title_sort | management of classical hodgkin s lymphoma past present and future |
| url | http://dx.doi.org/10.1155/2011/865870 |
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