Epigenetics disruptions enabled by porphyrin-derived metal-organic frameworks disarm resistances to sonocatalytic ROS anti-tumor actions
Post-transcriptional epigenetic modifications provide numerous implications for tumor progression, metastasis and recurrence, which also pose resistances to reactive oxygen species (ROS)-based anti-tumor. Herein, we proposed an epigenetic deubiquitination disruption strategy to disarm the ubiquitina...
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| Format: | Article |
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KeAi Communications Co. Ltd.
2025-01-01
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| Series: | Fundamental Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667325822002977 |
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| author | Yan Zhang Dou Du Chao Fang Xin Yu Yujia Fang Xinyu Liu Di Ou Haohao Yin Hui Liu Taixia Wang Lu Lu Xiaolong Li Kun Zhang |
| author_facet | Yan Zhang Dou Du Chao Fang Xin Yu Yujia Fang Xinyu Liu Di Ou Haohao Yin Hui Liu Taixia Wang Lu Lu Xiaolong Li Kun Zhang |
| author_sort | Yan Zhang |
| collection | DOAJ |
| description | Post-transcriptional epigenetic modifications provide numerous implications for tumor progression, metastasis and recurrence, which also pose resistances to reactive oxygen species (ROS)-based anti-tumor. Herein, we proposed an epigenetic deubiquitination disruption strategy to disarm the ubiquitination-deubiquitination balance-induced resistances to ROS production and ROS-based anti-tumor action for potentiating sonodynamic treatment (SDT) efficiency. To end it, porphyrin-derived metal-organic framework (MOF) sonocatalytic nanoplatforms were developed to load deubiquitination inhibitors (i.e., Auranofin). Ultrasound-triggered Auranofin release from PCN224@Au has been validated to blockade the deubiquitinating process and drive proteasome-mediated target protein degradation. The epigenetic deubiquitination disruption not only synergized with MOF-mediated sonocatalytic ROS production, but also inactivate deubiquitinating enzymes, blockade the deubiquitination process and further remove these resistances, both of which mutually behaved as reciprocal impetuses to significantly magnify SDT outcomes against liver cancers. Such a deubiquitination-engineered disruption approach finds an unprecedented pathway to disarm deubiquitination-induced resistances to SDT and other ROS-based anti-tumor means, which also enlightens us to establish other post-transcriptional epigenetic modification disruption strategies to re-program the tumor microenvironment and elevate the anti-tumor efficiency of various treatment methods (e.g., immunotherapy). |
| format | Article |
| id | doaj-art-24df479fa79d452b8c7fae85c237aff6 |
| institution | Kabale University |
| issn | 2667-3258 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | KeAi Communications Co. Ltd. |
| record_format | Article |
| series | Fundamental Research |
| spelling | doaj-art-24df479fa79d452b8c7fae85c237aff62025-01-29T05:02:25ZengKeAi Communications Co. Ltd.Fundamental Research2667-32582025-01-0151296306Epigenetics disruptions enabled by porphyrin-derived metal-organic frameworks disarm resistances to sonocatalytic ROS anti-tumor actionsYan Zhang0Dou Du1Chao Fang2Xin Yu3Yujia Fang4Xinyu Liu5Di Ou6Haohao Yin7Hui Liu8Taixia Wang9Lu Lu10Xiaolong Li11Kun Zhang12Central Laboratory, Ultrasound Research and Education Institute, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Tongji University, Shanghai 200072, ChinaCentral Laboratory, Ultrasound Research and Education Institute, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Tongji University, Shanghai 200072, ChinaCentral Laboratory, Ultrasound Research and Education Institute, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Tongji University, Shanghai 200072, ChinaDepartment of Medical Oncology, Shanghai Pulmonary Hospital, Thoracic Cancer Institute, Tongji University School of Medicine, Tongji University, Shanghai 200433, ChinaDepartment of Medical Oncology, Shanghai Pulmonary Hospital, Thoracic Cancer Institute, Tongji University School of Medicine, Tongji University, Shanghai 200433, ChinaDepartment of Medical Oncology, Shanghai Pulmonary Hospital, Thoracic Cancer Institute, Tongji University School of Medicine, Tongji University, Shanghai 200433, ChinaCentral Laboratory, Ultrasound Research and Education Institute, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Tongji University, Shanghai 200072, ChinaCentral Laboratory, Ultrasound Research and Education Institute, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Tongji University, Shanghai 200072, ChinaCentral Laboratory, Ultrasound Research and Education Institute, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Tongji University, Shanghai 200072, ChinaCentral Laboratory, Ultrasound Research and Education Institute, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Tongji University, Shanghai 200072, ChinaCentral Laboratory, Ultrasound Research and Education Institute, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Tongji University, Shanghai 200072, ChinaCentral Laboratory, Ultrasound Research and Education Institute, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Tongji University, Shanghai 200072, ChinaCentral Laboratory, Ultrasound Research and Education Institute, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Tongji University, Shanghai 200072, China; Corresponding author.Post-transcriptional epigenetic modifications provide numerous implications for tumor progression, metastasis and recurrence, which also pose resistances to reactive oxygen species (ROS)-based anti-tumor. Herein, we proposed an epigenetic deubiquitination disruption strategy to disarm the ubiquitination-deubiquitination balance-induced resistances to ROS production and ROS-based anti-tumor action for potentiating sonodynamic treatment (SDT) efficiency. To end it, porphyrin-derived metal-organic framework (MOF) sonocatalytic nanoplatforms were developed to load deubiquitination inhibitors (i.e., Auranofin). Ultrasound-triggered Auranofin release from PCN224@Au has been validated to blockade the deubiquitinating process and drive proteasome-mediated target protein degradation. The epigenetic deubiquitination disruption not only synergized with MOF-mediated sonocatalytic ROS production, but also inactivate deubiquitinating enzymes, blockade the deubiquitination process and further remove these resistances, both of which mutually behaved as reciprocal impetuses to significantly magnify SDT outcomes against liver cancers. Such a deubiquitination-engineered disruption approach finds an unprecedented pathway to disarm deubiquitination-induced resistances to SDT and other ROS-based anti-tumor means, which also enlightens us to establish other post-transcriptional epigenetic modification disruption strategies to re-program the tumor microenvironment and elevate the anti-tumor efficiency of various treatment methods (e.g., immunotherapy).http://www.sciencedirect.com/science/article/pii/S2667325822002977Epigenetics engineeringUbiquitylation modulationSonocatalysisReactive oxygen species resistanceAnti-tumor action |
| spellingShingle | Yan Zhang Dou Du Chao Fang Xin Yu Yujia Fang Xinyu Liu Di Ou Haohao Yin Hui Liu Taixia Wang Lu Lu Xiaolong Li Kun Zhang Epigenetics disruptions enabled by porphyrin-derived metal-organic frameworks disarm resistances to sonocatalytic ROS anti-tumor actions Fundamental Research Epigenetics engineering Ubiquitylation modulation Sonocatalysis Reactive oxygen species resistance Anti-tumor action |
| title | Epigenetics disruptions enabled by porphyrin-derived metal-organic frameworks disarm resistances to sonocatalytic ROS anti-tumor actions |
| title_full | Epigenetics disruptions enabled by porphyrin-derived metal-organic frameworks disarm resistances to sonocatalytic ROS anti-tumor actions |
| title_fullStr | Epigenetics disruptions enabled by porphyrin-derived metal-organic frameworks disarm resistances to sonocatalytic ROS anti-tumor actions |
| title_full_unstemmed | Epigenetics disruptions enabled by porphyrin-derived metal-organic frameworks disarm resistances to sonocatalytic ROS anti-tumor actions |
| title_short | Epigenetics disruptions enabled by porphyrin-derived metal-organic frameworks disarm resistances to sonocatalytic ROS anti-tumor actions |
| title_sort | epigenetics disruptions enabled by porphyrin derived metal organic frameworks disarm resistances to sonocatalytic ros anti tumor actions |
| topic | Epigenetics engineering Ubiquitylation modulation Sonocatalysis Reactive oxygen species resistance Anti-tumor action |
| url | http://www.sciencedirect.com/science/article/pii/S2667325822002977 |
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