Wearable devices may aid the recognition of fluctuation-related pain in Parkinson's disease-An exploratory, cross-sectional analysis of two prospective observational studies.
Fluctuation-related pain (FRP) affects more than one third of people with Parkinson's disease (PwP, PD) and has a harmful effect on health-related quality of life (HRQoL), but often remains under-reported by patients and neglected by clinicians. The National Institute for Health and Care Excell...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2025-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0316563 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832540233982279680 |
|---|---|
| author | Katarina Rukavina Juliet Staunton Pavlos Zinzalias Magdalena Krbot Skoric Kit Wu Kirsty Bannister Alexandra Rizos K Ray Chaudhuri |
| author_facet | Katarina Rukavina Juliet Staunton Pavlos Zinzalias Magdalena Krbot Skoric Kit Wu Kirsty Bannister Alexandra Rizos K Ray Chaudhuri |
| author_sort | Katarina Rukavina |
| collection | DOAJ |
| description | Fluctuation-related pain (FRP) affects more than one third of people with Parkinson's disease (PwP, PD) and has a harmful effect on health-related quality of life (HRQoL), but often remains under-reported by patients and neglected by clinicians. The National Institute for Health and Care Excellence (NICE) recommends The Parkinson KinetiGraphTM (the PKGTM) for remote monitoring of motor symptoms. We investigated potential links between the PKGTM-obtained parameters and clinical rating scores for FRP in PwP in an exploratory, cross-sectional analysis of two prospective studies: "The Non-motor International Longitudinal, Real-Life Study in PD-NILS" and "An observational-based registry of baseline PKG™ in PD-PKGReg". 63 PwP (41.3% female; age: 64.24±9.88 years; disease duration, DD: 6.83±5.63 years; Hoehn and Yahr Stage, H&Y: 2 (1-4); Levodopa Equivalent Daily Dose 535 (0-3230) mg) were included. PwP with FRP (n = 23) had longer DD (8.88 (1.29-19.05) vs. 3.16 (0.34-28.92), p = 0.001), higher severity of motor symptoms (H&Y 3 (1-4) vs. 2 (1-4), p = 0.015; SCOPA Motor total score 21.35±10.19 vs. 13.65±8.99, p = 0.003), more dyskinesia (SCOPA Motor Item 18 ≥1 60.9% vs. 7.5%, p<0.001), and worse HRQoL (PDQ-8 Total Score 10.74±5.98 vs. 6.78±5.13, p = 0.007) then PwP without FRP (n = 40). In the multivariate logistic regression, after the adjustment for DD, H&Y and SCOPA-Motor total score, the presence of FRP was significantly associated with the PKGTM-derived Fluctuation-dyskinesia score (Exp (B) = 1.305, 95% CI for Exp (B) 1.012-1.683, p = 0.040) and the Bradykinesia score (Exp (B) = 0.917, 95% CI for Exp (B) 0.842-0.999, p = 0.048). The PKGTM system may potentially advance the way we screen for, assess, and treat FRP in clinical practice. |
| format | Article |
| id | doaj-art-24d3dc7915454bd0a29448d20d761c21 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-24d3dc7915454bd0a29448d20d761c212025-02-05T05:31:27ZengPublic Library of Science (PLoS)PLoS ONE1932-62032025-01-01201e031656310.1371/journal.pone.0316563Wearable devices may aid the recognition of fluctuation-related pain in Parkinson's disease-An exploratory, cross-sectional analysis of two prospective observational studies.Katarina RukavinaJuliet StauntonPavlos ZinzaliasMagdalena Krbot SkoricKit WuKirsty BannisterAlexandra RizosK Ray ChaudhuriFluctuation-related pain (FRP) affects more than one third of people with Parkinson's disease (PwP, PD) and has a harmful effect on health-related quality of life (HRQoL), but often remains under-reported by patients and neglected by clinicians. The National Institute for Health and Care Excellence (NICE) recommends The Parkinson KinetiGraphTM (the PKGTM) for remote monitoring of motor symptoms. We investigated potential links between the PKGTM-obtained parameters and clinical rating scores for FRP in PwP in an exploratory, cross-sectional analysis of two prospective studies: "The Non-motor International Longitudinal, Real-Life Study in PD-NILS" and "An observational-based registry of baseline PKG™ in PD-PKGReg". 63 PwP (41.3% female; age: 64.24±9.88 years; disease duration, DD: 6.83±5.63 years; Hoehn and Yahr Stage, H&Y: 2 (1-4); Levodopa Equivalent Daily Dose 535 (0-3230) mg) were included. PwP with FRP (n = 23) had longer DD (8.88 (1.29-19.05) vs. 3.16 (0.34-28.92), p = 0.001), higher severity of motor symptoms (H&Y 3 (1-4) vs. 2 (1-4), p = 0.015; SCOPA Motor total score 21.35±10.19 vs. 13.65±8.99, p = 0.003), more dyskinesia (SCOPA Motor Item 18 ≥1 60.9% vs. 7.5%, p<0.001), and worse HRQoL (PDQ-8 Total Score 10.74±5.98 vs. 6.78±5.13, p = 0.007) then PwP without FRP (n = 40). In the multivariate logistic regression, after the adjustment for DD, H&Y and SCOPA-Motor total score, the presence of FRP was significantly associated with the PKGTM-derived Fluctuation-dyskinesia score (Exp (B) = 1.305, 95% CI for Exp (B) 1.012-1.683, p = 0.040) and the Bradykinesia score (Exp (B) = 0.917, 95% CI for Exp (B) 0.842-0.999, p = 0.048). The PKGTM system may potentially advance the way we screen for, assess, and treat FRP in clinical practice.https://doi.org/10.1371/journal.pone.0316563 |
| spellingShingle | Katarina Rukavina Juliet Staunton Pavlos Zinzalias Magdalena Krbot Skoric Kit Wu Kirsty Bannister Alexandra Rizos K Ray Chaudhuri Wearable devices may aid the recognition of fluctuation-related pain in Parkinson's disease-An exploratory, cross-sectional analysis of two prospective observational studies. PLoS ONE |
| title | Wearable devices may aid the recognition of fluctuation-related pain in Parkinson's disease-An exploratory, cross-sectional analysis of two prospective observational studies. |
| title_full | Wearable devices may aid the recognition of fluctuation-related pain in Parkinson's disease-An exploratory, cross-sectional analysis of two prospective observational studies. |
| title_fullStr | Wearable devices may aid the recognition of fluctuation-related pain in Parkinson's disease-An exploratory, cross-sectional analysis of two prospective observational studies. |
| title_full_unstemmed | Wearable devices may aid the recognition of fluctuation-related pain in Parkinson's disease-An exploratory, cross-sectional analysis of two prospective observational studies. |
| title_short | Wearable devices may aid the recognition of fluctuation-related pain in Parkinson's disease-An exploratory, cross-sectional analysis of two prospective observational studies. |
| title_sort | wearable devices may aid the recognition of fluctuation related pain in parkinson s disease an exploratory cross sectional analysis of two prospective observational studies |
| url | https://doi.org/10.1371/journal.pone.0316563 |
| work_keys_str_mv | AT katarinarukavina wearabledevicesmayaidtherecognitionoffluctuationrelatedpaininparkinsonsdiseaseanexploratorycrosssectionalanalysisoftwoprospectiveobservationalstudies AT julietstaunton wearabledevicesmayaidtherecognitionoffluctuationrelatedpaininparkinsonsdiseaseanexploratorycrosssectionalanalysisoftwoprospectiveobservationalstudies AT pavloszinzalias wearabledevicesmayaidtherecognitionoffluctuationrelatedpaininparkinsonsdiseaseanexploratorycrosssectionalanalysisoftwoprospectiveobservationalstudies AT magdalenakrbotskoric wearabledevicesmayaidtherecognitionoffluctuationrelatedpaininparkinsonsdiseaseanexploratorycrosssectionalanalysisoftwoprospectiveobservationalstudies AT kitwu wearabledevicesmayaidtherecognitionoffluctuationrelatedpaininparkinsonsdiseaseanexploratorycrosssectionalanalysisoftwoprospectiveobservationalstudies AT kirstybannister wearabledevicesmayaidtherecognitionoffluctuationrelatedpaininparkinsonsdiseaseanexploratorycrosssectionalanalysisoftwoprospectiveobservationalstudies AT alexandrarizos wearabledevicesmayaidtherecognitionoffluctuationrelatedpaininparkinsonsdiseaseanexploratorycrosssectionalanalysisoftwoprospectiveobservationalstudies AT kraychaudhuri wearabledevicesmayaidtherecognitionoffluctuationrelatedpaininparkinsonsdiseaseanexploratorycrosssectionalanalysisoftwoprospectiveobservationalstudies |