Autoimmune Cytopenias in Chronic Lymphocytic Leukemia
The clinical course of chronic lymphocytic leukemia (CLL) may be complicated at any time by autoimmune phenomena.The most common ones are hematologic disorders, such as autoimmune hemolytic anemia (AIHA) and immune thrombocytopenia (ITP). Pure red cell aplasia (PRCA) and autoimmune agranulocytosis (...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2013/730131 |
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| author | Giovanni D'Arena Roberto Guariglia Francesco La Rocca Stefania Trino Valentina Condelli Laura De Martino Vincenzo De Feo Pellegrino Musto |
| author_facet | Giovanni D'Arena Roberto Guariglia Francesco La Rocca Stefania Trino Valentina Condelli Laura De Martino Vincenzo De Feo Pellegrino Musto |
| author_sort | Giovanni D'Arena |
| collection | DOAJ |
| description | The clinical course of chronic lymphocytic leukemia (CLL) may be complicated at any time by autoimmune phenomena.The most common ones are hematologic disorders, such as autoimmune hemolytic anemia (AIHA) and immune thrombocytopenia (ITP). Pure red cell aplasia (PRCA) and autoimmune agranulocytosis (AG) are, indeed, more rarely seen. However, they are probably underestimated due to the possible misleading presence of cytopenias secondary to leukemic bone marrow involvement or to chemotherapy cytotoxicity. The source of autoantibodies is still uncertain, despite the most convincing data are in favor of the involvement of resting normal B-cells. In general, excluding the specific treatment of underlying CLL, the managementof these complications is not different from that of idiopathic autoimmune cytopenias or of those associated to other causes. Among different therapeutic approaches, monoclonal antibody rituximab, given alone or in combination, has shown to be very effective. |
| format | Article |
| id | doaj-art-24d32ca522ff4fc6bbf5d0b06dc988c5 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-24d32ca522ff4fc6bbf5d0b06dc988c52025-02-03T01:32:08ZengWileyClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/730131730131Autoimmune Cytopenias in Chronic Lymphocytic LeukemiaGiovanni D'Arena0Roberto Guariglia1Francesco La Rocca2Stefania Trino3Valentina Condelli4Laura De Martino5Vincenzo De Feo6Pellegrino Musto7Onco-Hematology Department, IRCCS Centro di Riferimento Oncologico della Basilicata, 85028 Rionero in Vulture, ItalyOnco-Hematology Department, IRCCS Centro di Riferimento Oncologico della Basilicata, 85028 Rionero in Vulture, ItalyLaboratory of Pre-clinical and Translational Research, IRCCS Centro di Riferimento Oncologico della Basilicata, 85028 Rionero in Vulture, ItalyLaboratory of Pre-clinical and Translational Research, IRCCS Centro di Riferimento Oncologico della Basilicata, 85028 Rionero in Vulture, ItalyLaboratory of Pre-clinical and Translational Research, IRCCS Centro di Riferimento Oncologico della Basilicata, 85028 Rionero in Vulture, ItalyDepartment of Pharmaceutical and Biomedical Sciences, University of Salerno, 84131 Salerno, ItalyDepartment of Pharmaceutical and Biomedical Sciences, University of Salerno, 84131 Salerno, ItalyOnco-Hematology Department, IRCCS Centro di Riferimento Oncologico della Basilicata, 85028 Rionero in Vulture, ItalyThe clinical course of chronic lymphocytic leukemia (CLL) may be complicated at any time by autoimmune phenomena.The most common ones are hematologic disorders, such as autoimmune hemolytic anemia (AIHA) and immune thrombocytopenia (ITP). Pure red cell aplasia (PRCA) and autoimmune agranulocytosis (AG) are, indeed, more rarely seen. However, they are probably underestimated due to the possible misleading presence of cytopenias secondary to leukemic bone marrow involvement or to chemotherapy cytotoxicity. The source of autoantibodies is still uncertain, despite the most convincing data are in favor of the involvement of resting normal B-cells. In general, excluding the specific treatment of underlying CLL, the managementof these complications is not different from that of idiopathic autoimmune cytopenias or of those associated to other causes. Among different therapeutic approaches, monoclonal antibody rituximab, given alone or in combination, has shown to be very effective.http://dx.doi.org/10.1155/2013/730131 |
| spellingShingle | Giovanni D'Arena Roberto Guariglia Francesco La Rocca Stefania Trino Valentina Condelli Laura De Martino Vincenzo De Feo Pellegrino Musto Autoimmune Cytopenias in Chronic Lymphocytic Leukemia Clinical and Developmental Immunology |
| title | Autoimmune Cytopenias in Chronic Lymphocytic Leukemia |
| title_full | Autoimmune Cytopenias in Chronic Lymphocytic Leukemia |
| title_fullStr | Autoimmune Cytopenias in Chronic Lymphocytic Leukemia |
| title_full_unstemmed | Autoimmune Cytopenias in Chronic Lymphocytic Leukemia |
| title_short | Autoimmune Cytopenias in Chronic Lymphocytic Leukemia |
| title_sort | autoimmune cytopenias in chronic lymphocytic leukemia |
| url | http://dx.doi.org/10.1155/2013/730131 |
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