Comprehensive Characterization of Bihormonal Cells and Endocrine Cell Lineages in Mammalian Pancreatic Islets

Comprehensive Characterization of Bihormonal Cells and Endocrine Cell Lineages in Mammalian Pancreatic Islets

Abstract Understanding the role and prevalence of bihormonal cells in pancreatic islets and their potential in β‐cell restoration is critical but remains ambiguous. Using genetically engineered mouse strains with specific fluorescent markers and advanced imaging flow cytometry, it is found that biho...

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Bibliographic Details
Main Authors: Xin‐Xin Yu, Peng Peng, Yi‐Ning Wang, Mao‐Yang He, Shuang He, Chen‐Tao Jin, Liu Yang, Xi Wang, Jia‐Xi Zheng, Jie Gao, Cheng‐Ran Xu
Format: Article
Language:English
Published: Wiley 2025-08-01
Series:Advanced Science
Subjects:
δ‐cell subpopulations
bihormonal cells
endocrine cell heterogeneity
gene coexpression network
imaging flow cytometry
pancreatic islets
Online Access:https://doi.org/10.1002/advs.202416326
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