Omentin associates with serum metabolite profiles indicating lower diabetes risk: KORA F4 Study
Introduction Circulating omentin levels have been positively associated with insulin sensitivity. Although a role for adiponectin in this relationship has been suggested, underlying mechanisms remain elusive. In order to reveal the relationship between omentin and systemic metabolism, this study aim...
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BMJ Publishing Group
2024-04-01
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| Series: | BMJ Open Diabetes Research & Care |
| Online Access: | https://drc.bmj.com/content/12/2/e003865.full |
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| author | Barbara Thorand Annette Peters Wolfgang Rathmann Michael Roden Christian Herder Jerzy Adamski Cornelia Prehn Rui Wang-Sattler Karsten Suhre Jacqueline M Ratter-Rieck Mengya Shi |
| author_facet | Barbara Thorand Annette Peters Wolfgang Rathmann Michael Roden Christian Herder Jerzy Adamski Cornelia Prehn Rui Wang-Sattler Karsten Suhre Jacqueline M Ratter-Rieck Mengya Shi |
| author_sort | Barbara Thorand |
| collection | DOAJ |
| description | Introduction Circulating omentin levels have been positively associated with insulin sensitivity. Although a role for adiponectin in this relationship has been suggested, underlying mechanisms remain elusive. In order to reveal the relationship between omentin and systemic metabolism, this study aimed to investigate associations of serum concentrations of omentin and metabolites.Research design and methods This study is based on 1124 participants aged 61–82 years from the population-based KORA (Cooperative Health Research in the Region of Augsburg) F4 Study, for whom both serum omentin levels and metabolite concentration profiles were available. Associations were assessed with five multivariable regression models, which were stepwise adjusted for multiple potential confounders, including age, sex, body mass index, waist-to-hip ratio, lifestyle markers (physical activity, smoking behavior and alcohol consumption), serum adiponectin levels, high-density lipoprotein cholesterol, use of lipid-lowering or anti-inflammatory medication, history of myocardial infarction and stroke, homeostasis model assessment 2 of insulin resistance, diabetes status, and use of oral glucose-lowering medication and insulin.Results Omentin levels significantly associated with multiple metabolites including amino acids, acylcarnitines, and lipids (eg, sphingomyelins and phosphatidylcholines (PCs)). Positive associations for several PCs, such as diacyl (PC aa C32:1) and alkyl-alkyl (PC ae C32:2), were significant in models 1–4, whereas those with hydroxytetradecenoylcarnitine (C14:1-OH) were significant in all five models. Omentin concentrations were negatively associated with several metabolite ratios, such as the valine-to-PC ae C32:2 and the serine-to-PC ae C32:2 ratios in most models.Conclusions Our results suggest that omentin may influence insulin sensitivity and diabetes risk by changing systemic lipid metabolism, but further mechanistic studies investigating effects of omentin on metabolism of insulin-sensitive tissues are needed. |
| format | Article |
| id | doaj-art-24c47b4eeb7a49d8a33ed39a442f5c56 |
| institution | DOAJ |
| issn | 2052-4897 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open Diabetes Research & Care |
| spelling | doaj-art-24c47b4eeb7a49d8a33ed39a442f5c562025-08-20T02:50:44ZengBMJ Publishing GroupBMJ Open Diabetes Research & Care2052-48972024-04-0112210.1136/bmjdrc-2023-003865Omentin associates with serum metabolite profiles indicating lower diabetes risk: KORA F4 StudyBarbara Thorand0Annette Peters1Wolfgang Rathmann2Michael Roden3Christian Herder4Jerzy Adamski5Cornelia Prehn6Rui Wang-Sattler7Karsten Suhre8Jacqueline M Ratter-Rieck9Mengya Shi10Institute for Medical Information Processing, Biometry, and Epidemiology (IBE), Pettenkofer School of Public Health, Faculty of Medicine, Ludwig-Maximilians-Universität, Munich, GermanyInstitute for Medical Information Processing, Biometry and Epidemiology, Ludwig-Maximilians-Universität München, Munich, GermanyGerman Center for Diabetes Research, Partner Düsseldorf, Neuherberg, GermanyInstitute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich-Heine-University Düsseldorf, Düsseldorf, GermanyGerman Center for Diabetes Research (DZD), Partner Düsseldorf, Düsseldorf, GermanyInstitute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, SloveniaMetabolomics and Proteomics Core, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, GermanyInstitute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, GermanyDepartment of Physiology and Biophysics, Weill Cornell Medicine-Qatar, Doha, QatarInstitute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich-Heine-University Düsseldorf, Düsseldorf, GermanyTUM School of Medicine and Health, Technical University of Munich (TUM), Munich, GermanyIntroduction Circulating omentin levels have been positively associated with insulin sensitivity. Although a role for adiponectin in this relationship has been suggested, underlying mechanisms remain elusive. In order to reveal the relationship between omentin and systemic metabolism, this study aimed to investigate associations of serum concentrations of omentin and metabolites.Research design and methods This study is based on 1124 participants aged 61–82 years from the population-based KORA (Cooperative Health Research in the Region of Augsburg) F4 Study, for whom both serum omentin levels and metabolite concentration profiles were available. Associations were assessed with five multivariable regression models, which were stepwise adjusted for multiple potential confounders, including age, sex, body mass index, waist-to-hip ratio, lifestyle markers (physical activity, smoking behavior and alcohol consumption), serum adiponectin levels, high-density lipoprotein cholesterol, use of lipid-lowering or anti-inflammatory medication, history of myocardial infarction and stroke, homeostasis model assessment 2 of insulin resistance, diabetes status, and use of oral glucose-lowering medication and insulin.Results Omentin levels significantly associated with multiple metabolites including amino acids, acylcarnitines, and lipids (eg, sphingomyelins and phosphatidylcholines (PCs)). Positive associations for several PCs, such as diacyl (PC aa C32:1) and alkyl-alkyl (PC ae C32:2), were significant in models 1–4, whereas those with hydroxytetradecenoylcarnitine (C14:1-OH) were significant in all five models. Omentin concentrations were negatively associated with several metabolite ratios, such as the valine-to-PC ae C32:2 and the serine-to-PC ae C32:2 ratios in most models.Conclusions Our results suggest that omentin may influence insulin sensitivity and diabetes risk by changing systemic lipid metabolism, but further mechanistic studies investigating effects of omentin on metabolism of insulin-sensitive tissues are needed.https://drc.bmj.com/content/12/2/e003865.full |
| spellingShingle | Barbara Thorand Annette Peters Wolfgang Rathmann Michael Roden Christian Herder Jerzy Adamski Cornelia Prehn Rui Wang-Sattler Karsten Suhre Jacqueline M Ratter-Rieck Mengya Shi Omentin associates with serum metabolite profiles indicating lower diabetes risk: KORA F4 Study BMJ Open Diabetes Research & Care |
| title | Omentin associates with serum metabolite profiles indicating lower diabetes risk: KORA F4 Study |
| title_full | Omentin associates with serum metabolite profiles indicating lower diabetes risk: KORA F4 Study |
| title_fullStr | Omentin associates with serum metabolite profiles indicating lower diabetes risk: KORA F4 Study |
| title_full_unstemmed | Omentin associates with serum metabolite profiles indicating lower diabetes risk: KORA F4 Study |
| title_short | Omentin associates with serum metabolite profiles indicating lower diabetes risk: KORA F4 Study |
| title_sort | omentin associates with serum metabolite profiles indicating lower diabetes risk kora f4 study |
| url | https://drc.bmj.com/content/12/2/e003865.full |
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