Infrapatellar Fat Pad Stem Cells: From Developmental Biology to Cell Therapy
The ideal cell type to be used for cartilage therapy should possess a proven chondrogenic capacity, not cause donor-site morbidity, and should be readily expandable in culture without losing their phenotype. There are several cell sources being investigated to promote cartilage regeneration: mature...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2017/6843727 |
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| author | Ronaldo J. F. C. do Amaral Henrique V. Almeida Daniel J. Kelly Fergal J. O’Brien Cathal J. Kearney |
| author_facet | Ronaldo J. F. C. do Amaral Henrique V. Almeida Daniel J. Kelly Fergal J. O’Brien Cathal J. Kearney |
| author_sort | Ronaldo J. F. C. do Amaral |
| collection | DOAJ |
| description | The ideal cell type to be used for cartilage therapy should possess a proven chondrogenic capacity, not cause donor-site morbidity, and should be readily expandable in culture without losing their phenotype. There are several cell sources being investigated to promote cartilage regeneration: mature articular chondrocytes, chondrocyte progenitors, and various stem cells. Most recently, stem cells isolated from joint tissue, such as chondrogenic stem/progenitors from cartilage itself, synovial fluid, synovial membrane, and infrapatellar fat pad (IFP) have gained great attention due to their increased chondrogenic capacity over the bone marrow and subcutaneous adipose-derived stem cells. In this review, we first describe the IFP anatomy and compare and contrast it with other adipose tissues, with a particular focus on the embryological and developmental aspects of the tissue. We then discuss the recent advances in IFP stem cells for regenerative medicine. We compare their properties with other stem cell types and discuss an ontogeny relationship with other joint cells and their role on in vivo cartilage repair. We conclude with a perspective for future clinical trials using IFP stem cells. |
| format | Article |
| id | doaj-art-24c06f8df1504bf7aa8f143d6cce99bc |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-24c06f8df1504bf7aa8f143d6cce99bc2025-02-03T01:03:38ZengWileyStem Cells International1687-966X1687-96782017-01-01201710.1155/2017/68437276843727Infrapatellar Fat Pad Stem Cells: From Developmental Biology to Cell TherapyRonaldo J. F. C. do Amaral0Henrique V. Almeida1Daniel J. Kelly2Fergal J. O’Brien3Cathal J. Kearney4Tissue Engineering Research Group, Department of Anatomy, Royal College of Surgeons in Ireland, Dublin, IrelandCNC, Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 Coimbra, PortugalTrinity Centre for Bioengineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, IrelandTissue Engineering Research Group, Department of Anatomy, Royal College of Surgeons in Ireland, Dublin, IrelandTissue Engineering Research Group, Department of Anatomy, Royal College of Surgeons in Ireland, Dublin, IrelandThe ideal cell type to be used for cartilage therapy should possess a proven chondrogenic capacity, not cause donor-site morbidity, and should be readily expandable in culture without losing their phenotype. There are several cell sources being investigated to promote cartilage regeneration: mature articular chondrocytes, chondrocyte progenitors, and various stem cells. Most recently, stem cells isolated from joint tissue, such as chondrogenic stem/progenitors from cartilage itself, synovial fluid, synovial membrane, and infrapatellar fat pad (IFP) have gained great attention due to their increased chondrogenic capacity over the bone marrow and subcutaneous adipose-derived stem cells. In this review, we first describe the IFP anatomy and compare and contrast it with other adipose tissues, with a particular focus on the embryological and developmental aspects of the tissue. We then discuss the recent advances in IFP stem cells for regenerative medicine. We compare their properties with other stem cell types and discuss an ontogeny relationship with other joint cells and their role on in vivo cartilage repair. We conclude with a perspective for future clinical trials using IFP stem cells.http://dx.doi.org/10.1155/2017/6843727 |
| spellingShingle | Ronaldo J. F. C. do Amaral Henrique V. Almeida Daniel J. Kelly Fergal J. O’Brien Cathal J. Kearney Infrapatellar Fat Pad Stem Cells: From Developmental Biology to Cell Therapy Stem Cells International |
| title | Infrapatellar Fat Pad Stem Cells: From Developmental Biology to Cell Therapy |
| title_full | Infrapatellar Fat Pad Stem Cells: From Developmental Biology to Cell Therapy |
| title_fullStr | Infrapatellar Fat Pad Stem Cells: From Developmental Biology to Cell Therapy |
| title_full_unstemmed | Infrapatellar Fat Pad Stem Cells: From Developmental Biology to Cell Therapy |
| title_short | Infrapatellar Fat Pad Stem Cells: From Developmental Biology to Cell Therapy |
| title_sort | infrapatellar fat pad stem cells from developmental biology to cell therapy |
| url | http://dx.doi.org/10.1155/2017/6843727 |
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