Proinflammatory Cytokine IL-17 Shows a Significant Association with Helicobacter pylori Infection and Disease Severity
Background. The pro- and anti-inflammatory cytokines play an important role in the immune response against H. pylori infection. The proinflammatory cytokines of Th17 cells have been suggested to play a major role in H. pylori infection and resulting gastric inflammation. Objective. The objective of...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2017/6265150 |
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| author | Piyumali Sandareka Arachchi Neluka Fernando Manjula Manoji Weerasekera Bimalka Senevirathna Deepaka D. Weerasekera Chinthika Prabhashinie Gunasekara |
| author_facet | Piyumali Sandareka Arachchi Neluka Fernando Manjula Manoji Weerasekera Bimalka Senevirathna Deepaka D. Weerasekera Chinthika Prabhashinie Gunasekara |
| author_sort | Piyumali Sandareka Arachchi |
| collection | DOAJ |
| description | Background. The pro- and anti-inflammatory cytokines play an important role in the immune response against H. pylori infection. The proinflammatory cytokines of Th17 cells have been suggested to play a major role in H. pylori infection and resulting gastric inflammation. Objective. The objective of this study was to compare the expression of selected inflammatory cytokines (IL-10, IL-17, IL-21, IL-23, and TNF-α) in H. pylori-infected patients and healthy controls and to understand their association with H. pylori infection and disease severity. Results. The expression levels of IL-17 and IL-23 were significantly higher in H. pylori-infected patients. The expression of IL-21 was also higher in H. pylori-positive patients but there was no significant association with infection. IL-17 expression showed a significant increase with the severity of chronic gastritis. Conclusion. The proinflammatory cytokine, IL-17, shows a significant association with H. pylori infection and disease severity in a Sri Lankan dyspeptic patient population. |
| format | Article |
| id | doaj-art-24acb7c8371d48e7b4e9f4e5181f9b54 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-24acb7c8371d48e7b4e9f4e5181f9b542025-08-20T03:54:56ZengWileyGastroenterology Research and Practice1687-61211687-630X2017-01-01201710.1155/2017/62651506265150Proinflammatory Cytokine IL-17 Shows a Significant Association with Helicobacter pylori Infection and Disease SeverityPiyumali Sandareka Arachchi0Neluka Fernando1Manjula Manoji Weerasekera2Bimalka Senevirathna3Deepaka D. Weerasekera4Chinthika Prabhashinie Gunasekara5Department of Microbiology, Faculty of Medical Sciences, University of Sri Jayewardenepura, Gangodawila, Nugegoda, Sri LankaDepartment of Microbiology, Faculty of Medical Sciences, University of Sri Jayewardenepura, Gangodawila, Nugegoda, Sri LankaDepartment of Microbiology, Faculty of Medical Sciences, University of Sri Jayewardenepura, Gangodawila, Nugegoda, Sri LankaDepartment of Pathology, Faculty of Medical Sciences, University of Sri Jayewardenepura, Gangodawila, Nugegoda, Sri LankaDepartment of Surgery, Faculty of Medical Sciences, University of Sri Jayewardenepura, Gangodawila, Nugegoda, Sri LankaDepartment of Microbiology, Faculty of Medical Sciences, University of Sri Jayewardenepura, Gangodawila, Nugegoda, Sri LankaBackground. The pro- and anti-inflammatory cytokines play an important role in the immune response against H. pylori infection. The proinflammatory cytokines of Th17 cells have been suggested to play a major role in H. pylori infection and resulting gastric inflammation. Objective. The objective of this study was to compare the expression of selected inflammatory cytokines (IL-10, IL-17, IL-21, IL-23, and TNF-α) in H. pylori-infected patients and healthy controls and to understand their association with H. pylori infection and disease severity. Results. The expression levels of IL-17 and IL-23 were significantly higher in H. pylori-infected patients. The expression of IL-21 was also higher in H. pylori-positive patients but there was no significant association with infection. IL-17 expression showed a significant increase with the severity of chronic gastritis. Conclusion. The proinflammatory cytokine, IL-17, shows a significant association with H. pylori infection and disease severity in a Sri Lankan dyspeptic patient population.http://dx.doi.org/10.1155/2017/6265150 |
| spellingShingle | Piyumali Sandareka Arachchi Neluka Fernando Manjula Manoji Weerasekera Bimalka Senevirathna Deepaka D. Weerasekera Chinthika Prabhashinie Gunasekara Proinflammatory Cytokine IL-17 Shows a Significant Association with Helicobacter pylori Infection and Disease Severity Gastroenterology Research and Practice |
| title | Proinflammatory Cytokine IL-17 Shows a Significant Association with Helicobacter pylori Infection and Disease Severity |
| title_full | Proinflammatory Cytokine IL-17 Shows a Significant Association with Helicobacter pylori Infection and Disease Severity |
| title_fullStr | Proinflammatory Cytokine IL-17 Shows a Significant Association with Helicobacter pylori Infection and Disease Severity |
| title_full_unstemmed | Proinflammatory Cytokine IL-17 Shows a Significant Association with Helicobacter pylori Infection and Disease Severity |
| title_short | Proinflammatory Cytokine IL-17 Shows a Significant Association with Helicobacter pylori Infection and Disease Severity |
| title_sort | proinflammatory cytokine il 17 shows a significant association with helicobacter pylori infection and disease severity |
| url | http://dx.doi.org/10.1155/2017/6265150 |
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