The Impact of a Pulmonary-Artery-Catheter-Based Protocol on Fluid and Catecholamine Administration in Early Sepsis
Objective. The pulmonary artery catheter (PAC) remains topic of debate. Despite abundant data, it is of note that many trials did not incorporate a treatment protocol. Methods. We retrospectively evaluated fluid balances and catecholamine doses in septic patients after the introduction of a PAC-bas...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Critical Care Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2012/161879 |
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| author | Carina Bethlehem Frouwke M. Groenwold Hanneke Buter W. Peter Kingma Michael A. Kuiper Fellery de Lange Paul Elbers Henk Groen Eric N. van Roon E. Christiaan Boerma |
| author_facet | Carina Bethlehem Frouwke M. Groenwold Hanneke Buter W. Peter Kingma Michael A. Kuiper Fellery de Lange Paul Elbers Henk Groen Eric N. van Roon E. Christiaan Boerma |
| author_sort | Carina Bethlehem |
| collection | DOAJ |
| description | Objective. The pulmonary artery catheter (PAC) remains topic of debate. Despite abundant data, it is of note that many trials did not incorporate a treatment protocol.
Methods. We retrospectively evaluated fluid balances and catecholamine doses in septic patients after the introduction of a PAC-based treatment protocol in comparison to historic controls. Results. 2×70 patients were included. The first day the PAC group had a significantly higher positive fluid balance in comparison to controls (6.1±2.6 versus 3.8±2.4
litre, 𝑃<0.001). After 7 days the cumulative fluid balance in the PAC group was significantly lower than in controls (9.4±7.4
versus 13±7.6 litre, 𝑃=0.001). Maximum dose of norepinephrine was significantly higher in the PAC group. Compared to controls this was associated with a significant reduction in ventilator and ICU days. Conclusions. Introduction of a PAC-based treatment protocol in sepsis changed the administration of fluid and vasopressors significantly. |
| format | Article |
| id | doaj-art-24aaeaca143a40d3bfe7b6293e409b02 |
| institution | Kabale University |
| issn | 2090-1305 2090-1313 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Critical Care Research and Practice |
| spelling | doaj-art-24aaeaca143a40d3bfe7b6293e409b022025-02-03T01:04:49ZengWileyCritical Care Research and Practice2090-13052090-13132012-01-01201210.1155/2012/161879161879The Impact of a Pulmonary-Artery-Catheter-Based Protocol on Fluid and Catecholamine Administration in Early SepsisCarina Bethlehem0Frouwke M. Groenwold1Hanneke Buter2W. Peter Kingma3Michael A. Kuiper4Fellery de Lange5Paul Elbers6Henk Groen7Eric N. van Roon8E. Christiaan Boerma9Department of Intensive Care, Medical Centre Leeuwarden, P.O. Box 888, 8901 BR Leeuwarden, The NetherlandsDepartment of Intensive Care, Medical Centre Leeuwarden, P.O. Box 888, 8901 BR Leeuwarden, The NetherlandsDepartment of Intensive Care, Medical Centre Leeuwarden, P.O. Box 888, 8901 BR Leeuwarden, The NetherlandsDepartment of Intensive Care, Medical Centre Leeuwarden, P.O. Box 888, 8901 BR Leeuwarden, The NetherlandsDepartment of Intensive Care, Medical Centre Leeuwarden, P.O. Box 888, 8901 BR Leeuwarden, The NetherlandsDepartment of Intensive Care, Medical Centre Leeuwarden, P.O. Box 888, 8901 BR Leeuwarden, The NetherlandsDepartment of Intensive Care, Medical Centre Leeuwarden, P.O. Box 888, 8901 BR Leeuwarden, The NetherlandsDepartment of Epidemiology, University Medical Centre Groningen, P.O. Box 30001, 9700 RB Groningen, The NetherlandsDepartment of Clinical Pharmacy and Clinical Pharmacology, Medical Centre Leeuwarden, P.O. Box 888, 8901 BR Leeuwarden, The NetherlandsDepartment of Intensive Care, Medical Centre Leeuwarden, P.O. Box 888, 8901 BR Leeuwarden, The NetherlandsObjective. The pulmonary artery catheter (PAC) remains topic of debate. Despite abundant data, it is of note that many trials did not incorporate a treatment protocol. Methods. We retrospectively evaluated fluid balances and catecholamine doses in septic patients after the introduction of a PAC-based treatment protocol in comparison to historic controls. Results. 2×70 patients were included. The first day the PAC group had a significantly higher positive fluid balance in comparison to controls (6.1±2.6 versus 3.8±2.4 litre, 𝑃<0.001). After 7 days the cumulative fluid balance in the PAC group was significantly lower than in controls (9.4±7.4 versus 13±7.6 litre, 𝑃=0.001). Maximum dose of norepinephrine was significantly higher in the PAC group. Compared to controls this was associated with a significant reduction in ventilator and ICU days. Conclusions. Introduction of a PAC-based treatment protocol in sepsis changed the administration of fluid and vasopressors significantly.http://dx.doi.org/10.1155/2012/161879 |
| spellingShingle | Carina Bethlehem Frouwke M. Groenwold Hanneke Buter W. Peter Kingma Michael A. Kuiper Fellery de Lange Paul Elbers Henk Groen Eric N. van Roon E. Christiaan Boerma The Impact of a Pulmonary-Artery-Catheter-Based Protocol on Fluid and Catecholamine Administration in Early Sepsis Critical Care Research and Practice |
| title | The Impact of a Pulmonary-Artery-Catheter-Based Protocol on Fluid and Catecholamine Administration in Early Sepsis |
| title_full | The Impact of a Pulmonary-Artery-Catheter-Based Protocol on Fluid and Catecholamine Administration in Early Sepsis |
| title_fullStr | The Impact of a Pulmonary-Artery-Catheter-Based Protocol on Fluid and Catecholamine Administration in Early Sepsis |
| title_full_unstemmed | The Impact of a Pulmonary-Artery-Catheter-Based Protocol on Fluid and Catecholamine Administration in Early Sepsis |
| title_short | The Impact of a Pulmonary-Artery-Catheter-Based Protocol on Fluid and Catecholamine Administration in Early Sepsis |
| title_sort | impact of a pulmonary artery catheter based protocol on fluid and catecholamine administration in early sepsis |
| url | http://dx.doi.org/10.1155/2012/161879 |
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