Mitochondrial Dysfunction in Parkinson's Disease
Parkinson's disease (PD) is a progressive, neurodegenerative condition that has increasingly been linked with mitochondrial dysfunction and inhibition of the electron transport chain. This inhibition leads to the generation of reactive oxygen species and depletion of cellular energy levels, wh...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.4061/2011/716871 |
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| _version_ | 1832564734775263232 |
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| author | P. C. Keane M. Kurzawa P. G. Blain C. M. Morris |
| author_facet | P. C. Keane M. Kurzawa P. G. Blain C. M. Morris |
| author_sort | P. C. Keane |
| collection | DOAJ |
| description | Parkinson's disease (PD) is a progressive, neurodegenerative condition that has increasingly been linked with mitochondrial dysfunction and inhibition of the electron transport chain. This inhibition leads to the generation of reactive oxygen species and depletion of cellular energy levels, which can consequently cause cellular damage and death mediated by oxidative stress and excitotoxicity. A number of genes that have been shown to have links with inherited forms of PD encode mitochondrial proteins or proteins implicated in mitochondrial dysfunction, supporting the central involvement of mitochondria in PD. This involvement is corroborated by reports that environmental toxins that inhibit the mitochondrial respiratory chain have been shown to be associated with PD.
This paper aims to illustrate the considerable body of evidence linking mitochondrial dysfunction with neuronal cell death in the substantia nigra pars compacta (SNpc) of PD patients and to highlight the important need for further research in this area. |
| format | Article |
| id | doaj-art-249dc9aa3f4a4c7cb904a4eb9fff2c46 |
| institution | Kabale University |
| issn | 2042-0080 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-249dc9aa3f4a4c7cb904a4eb9fff2c462025-02-03T01:10:15ZengWileyParkinson's Disease2042-00802011-01-01201110.4061/2011/716871716871Mitochondrial Dysfunction in Parkinson's DiseaseP. C. Keane0M. Kurzawa1P. G. Blain2C. M. Morris3Medical Toxicology Centre, Wolfson Unit, Newcastle University, Claremont Place, Newcastle upon Tyne NE2 4AA, UKMedical Toxicology Centre, Wolfson Unit, Newcastle University, Claremont Place, Newcastle upon Tyne NE2 4AA, UKMedical Toxicology Centre, Wolfson Unit, Newcastle University, Claremont Place, Newcastle upon Tyne NE2 4AA, UKMedical Toxicology Centre, Wolfson Unit, Newcastle University, Claremont Place, Newcastle upon Tyne NE2 4AA, UKParkinson's disease (PD) is a progressive, neurodegenerative condition that has increasingly been linked with mitochondrial dysfunction and inhibition of the electron transport chain. This inhibition leads to the generation of reactive oxygen species and depletion of cellular energy levels, which can consequently cause cellular damage and death mediated by oxidative stress and excitotoxicity. A number of genes that have been shown to have links with inherited forms of PD encode mitochondrial proteins or proteins implicated in mitochondrial dysfunction, supporting the central involvement of mitochondria in PD. This involvement is corroborated by reports that environmental toxins that inhibit the mitochondrial respiratory chain have been shown to be associated with PD. This paper aims to illustrate the considerable body of evidence linking mitochondrial dysfunction with neuronal cell death in the substantia nigra pars compacta (SNpc) of PD patients and to highlight the important need for further research in this area.http://dx.doi.org/10.4061/2011/716871 |
| spellingShingle | P. C. Keane M. Kurzawa P. G. Blain C. M. Morris Mitochondrial Dysfunction in Parkinson's Disease Parkinson's Disease |
| title | Mitochondrial Dysfunction in Parkinson's Disease |
| title_full | Mitochondrial Dysfunction in Parkinson's Disease |
| title_fullStr | Mitochondrial Dysfunction in Parkinson's Disease |
| title_full_unstemmed | Mitochondrial Dysfunction in Parkinson's Disease |
| title_short | Mitochondrial Dysfunction in Parkinson's Disease |
| title_sort | mitochondrial dysfunction in parkinson s disease |
| url | http://dx.doi.org/10.4061/2011/716871 |
| work_keys_str_mv | AT pckeane mitochondrialdysfunctioninparkinsonsdisease AT mkurzawa mitochondrialdysfunctioninparkinsonsdisease AT pgblain mitochondrialdysfunctioninparkinsonsdisease AT cmmorris mitochondrialdysfunctioninparkinsonsdisease |