Genetic Diversity of Toll-Like Receptors and Immunity to M. leprae Infection
Genetic association studies of leprosy cohorts across the world have identified numerous polymorphisms which alter susceptibility and outcome to infection with Mycobacterium leprae. As expected, many of the polymorphisms reside within genes that encode components of the innate and adaptive immune sy...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Tropical Medicine |
| Online Access: | http://dx.doi.org/10.1155/2012/415057 |
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| _version_ | 1832566741412085760 |
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| author | Bryan E. Hart Richard I. Tapping |
| author_facet | Bryan E. Hart Richard I. Tapping |
| author_sort | Bryan E. Hart |
| collection | DOAJ |
| description | Genetic association studies of leprosy cohorts across the world have identified numerous polymorphisms which alter susceptibility and outcome to infection with Mycobacterium leprae. As expected, many of the polymorphisms reside within genes that encode components of the innate and adaptive immune system. Despite the preponderance of these studies, our understanding of the mechanisms that underlie these genetic associations remains sparse. Toll-like receptors (TLRs) have emerged as an essential family of innate immune pattern recognition receptors which play a pivotal role in host defense against microbes, including pathogenic strains of mycobacteria. This paper will highlight studies which have uncovered the association of specific TLR gene polymorphisms with leprosy or tuberculosis: two important diseases resulting from mycobacterial infection. This analysis will focus on the potential influence these polymorphic variants have on TLR expression and function and how altered TLR recognition or signaling may contribute to successful antimycobacterial immunity. |
| format | Article |
| id | doaj-art-249b7cec46d740d59968d6203fb2ef8e |
| institution | Kabale University |
| issn | 1687-9686 1687-9694 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Tropical Medicine |
| spelling | doaj-art-249b7cec46d740d59968d6203fb2ef8e2025-02-03T01:03:19ZengWileyJournal of Tropical Medicine1687-96861687-96942012-01-01201210.1155/2012/415057415057Genetic Diversity of Toll-Like Receptors and Immunity to M. leprae InfectionBryan E. Hart0Richard I. Tapping1Department of Microbiology, University of Illinois, Urbana, IL 61801, USADepartment of Microbiology, University of Illinois, Urbana, IL 61801, USAGenetic association studies of leprosy cohorts across the world have identified numerous polymorphisms which alter susceptibility and outcome to infection with Mycobacterium leprae. As expected, many of the polymorphisms reside within genes that encode components of the innate and adaptive immune system. Despite the preponderance of these studies, our understanding of the mechanisms that underlie these genetic associations remains sparse. Toll-like receptors (TLRs) have emerged as an essential family of innate immune pattern recognition receptors which play a pivotal role in host defense against microbes, including pathogenic strains of mycobacteria. This paper will highlight studies which have uncovered the association of specific TLR gene polymorphisms with leprosy or tuberculosis: two important diseases resulting from mycobacterial infection. This analysis will focus on the potential influence these polymorphic variants have on TLR expression and function and how altered TLR recognition or signaling may contribute to successful antimycobacterial immunity.http://dx.doi.org/10.1155/2012/415057 |
| spellingShingle | Bryan E. Hart Richard I. Tapping Genetic Diversity of Toll-Like Receptors and Immunity to M. leprae Infection Journal of Tropical Medicine |
| title | Genetic Diversity of Toll-Like Receptors and Immunity to M. leprae Infection |
| title_full | Genetic Diversity of Toll-Like Receptors and Immunity to M. leprae Infection |
| title_fullStr | Genetic Diversity of Toll-Like Receptors and Immunity to M. leprae Infection |
| title_full_unstemmed | Genetic Diversity of Toll-Like Receptors and Immunity to M. leprae Infection |
| title_short | Genetic Diversity of Toll-Like Receptors and Immunity to M. leprae Infection |
| title_sort | genetic diversity of toll like receptors and immunity to m leprae infection |
| url | http://dx.doi.org/10.1155/2012/415057 |
| work_keys_str_mv | AT bryanehart geneticdiversityoftolllikereceptorsandimmunitytomlepraeinfection AT richarditapping geneticdiversityoftolllikereceptorsandimmunitytomlepraeinfection |