Harnessing the power of proteins in modulation of miRNAs for targeting Iron deficiency Anemia: Opinion for future implications and strategies
Iron Deficiency Anemia (IDA) remains a pervasive global health challenge, disproportionately affecting vulnerable populations such as women and children. This review explores the cutting-edge interplay between microRNAs (miRNAs) and proteins in erythropoiesis, highlighting novel therapeutic strategi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2025.1535498/full |
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| author | Ray Wagiu Basrowi Ray Wagiu Basrowi Ray Wagiu Basrowi Tonny Sundjaya Tonny Sundjaya Dessy Pratiwi Nurlinah Amalia Nurlinah Amalia Nurlinah Amalia Yosi Yohanes Putra Tandi Muhammad Yasir Syafa’atulloh Garuda Nusantara Putra Utomo Muhammad Abdir Rahman Albarok Fahrul Nurkolis |
| author_facet | Ray Wagiu Basrowi Ray Wagiu Basrowi Ray Wagiu Basrowi Tonny Sundjaya Tonny Sundjaya Dessy Pratiwi Nurlinah Amalia Nurlinah Amalia Nurlinah Amalia Yosi Yohanes Putra Tandi Muhammad Yasir Syafa’atulloh Garuda Nusantara Putra Utomo Muhammad Abdir Rahman Albarok Fahrul Nurkolis |
| author_sort | Ray Wagiu Basrowi |
| collection | DOAJ |
| description | Iron Deficiency Anemia (IDA) remains a pervasive global health challenge, disproportionately affecting vulnerable populations such as women and children. This review explores the cutting-edge interplay between microRNAs (miRNAs) and proteins in erythropoiesis, highlighting novel therapeutic strategies for IDA. Emerging evidence underscores the pivotal role of miRNAs—such as miR-15a, miR-24, miR-150, and miR-223—in regulating erythropoiesis, with dysregulation linked to hematologic and systemic diseases. Proteins, acting as modulators of miRNA activity, present innovative pathways for intervention by influencing erythropoiesis at multiple stages, from stem cell proliferation to red blood cell maturation. Our synthesis highlights key molecular mechanisms: miR-15a suppresses erythropoiesis by inhibiting c-Myb, miR-24 impairs heme biosynthesis through ALK4 regulation, while miR-150 and miR-223 modulate critical hematopoietic pathways affecting cell differentiation and apoptosis. These miRNA-protein interactions suggest targeted therapies such as protein-based miRNA modulators could optimize erythropoiesis, advancing IDA management. Additionally, the review emphasizes the potential of leveraging protein-miRNA interactions for precision medicine, especially in resource-limited settings where anemia’s burden is profound. By bridging current knowledge gaps, our proposed strategies offer personalized and scalable therapeutic solutions. This comprehensive perspective lays the groundwork for future interventions addressing one of the world’s most widespread public health crises. |
| format | Article |
| id | doaj-art-249882c359924a8b9742c32e720367bc |
| institution | Kabale University |
| issn | 2296-861X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj-art-249882c359924a8b9742c32e720367bc2025-01-27T05:14:41ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-01-011210.3389/fnut.2025.15354981535498Harnessing the power of proteins in modulation of miRNAs for targeting Iron deficiency Anemia: Opinion for future implications and strategiesRay Wagiu Basrowi0Ray Wagiu Basrowi1Ray Wagiu Basrowi2Tonny Sundjaya3Tonny Sundjaya4Dessy Pratiwi5Nurlinah Amalia6Nurlinah Amalia7Nurlinah Amalia8Yosi Yohanes Putra Tandi9Muhammad Yasir Syafa’atulloh10Garuda Nusantara Putra Utomo11Muhammad Abdir Rahman Albarok12Fahrul Nurkolis13Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, IndonesiaHealth Collaborative Center (HCC), Jakarta, IndonesiaDanone Specialized Nutrition, Jakarta, IndonesiaDanone Specialized Nutrition, Jakarta, IndonesiaDepartment of Epidemiology, Faculty of Public Health, Universitas Indonesia, Jakarta, IndonesiaDanone Specialized Nutrition, Jakarta, IndonesiaMedical Study Program, Faculty of Medicine, Brawijaya University, Malang, IndonesiaMaster Program of Biomedical Science, Faculty of Medicine, Brawijaya University, Malang, IndonesiaMedical Research Center of Indonesia, Surabaya, IndonesiaBachelor of Medicine, Faculty of Medicine, Universitas Padjadjaran, Bandung, IndonesiaMedical Study Program, Faculty of Medicine, Airlangga University, Surabaya, IndonesiaMedical Study Program, Faculty of Medicine, Airlangga University, Surabaya, IndonesiaMedical Study Program, Faculty of Medicine, Airlangga University, Surabaya, IndonesiaMedical Research Center of Indonesia, Surabaya, IndonesiaIron Deficiency Anemia (IDA) remains a pervasive global health challenge, disproportionately affecting vulnerable populations such as women and children. This review explores the cutting-edge interplay between microRNAs (miRNAs) and proteins in erythropoiesis, highlighting novel therapeutic strategies for IDA. Emerging evidence underscores the pivotal role of miRNAs—such as miR-15a, miR-24, miR-150, and miR-223—in regulating erythropoiesis, with dysregulation linked to hematologic and systemic diseases. Proteins, acting as modulators of miRNA activity, present innovative pathways for intervention by influencing erythropoiesis at multiple stages, from stem cell proliferation to red blood cell maturation. Our synthesis highlights key molecular mechanisms: miR-15a suppresses erythropoiesis by inhibiting c-Myb, miR-24 impairs heme biosynthesis through ALK4 regulation, while miR-150 and miR-223 modulate critical hematopoietic pathways affecting cell differentiation and apoptosis. These miRNA-protein interactions suggest targeted therapies such as protein-based miRNA modulators could optimize erythropoiesis, advancing IDA management. Additionally, the review emphasizes the potential of leveraging protein-miRNA interactions for precision medicine, especially in resource-limited settings where anemia’s burden is profound. By bridging current knowledge gaps, our proposed strategies offer personalized and scalable therapeutic solutions. This comprehensive perspective lays the groundwork for future interventions addressing one of the world’s most widespread public health crises.https://www.frontiersin.org/articles/10.3389/fnut.2025.1535498/fullmiRNAmicroRNAanemiaerythropoiesisproteiniron deficiency anemia |
| spellingShingle | Ray Wagiu Basrowi Ray Wagiu Basrowi Ray Wagiu Basrowi Tonny Sundjaya Tonny Sundjaya Dessy Pratiwi Nurlinah Amalia Nurlinah Amalia Nurlinah Amalia Yosi Yohanes Putra Tandi Muhammad Yasir Syafa’atulloh Garuda Nusantara Putra Utomo Muhammad Abdir Rahman Albarok Fahrul Nurkolis Harnessing the power of proteins in modulation of miRNAs for targeting Iron deficiency Anemia: Opinion for future implications and strategies Frontiers in Nutrition miRNA microRNA anemia erythropoiesis protein iron deficiency anemia |
| title | Harnessing the power of proteins in modulation of miRNAs for targeting Iron deficiency Anemia: Opinion for future implications and strategies |
| title_full | Harnessing the power of proteins in modulation of miRNAs for targeting Iron deficiency Anemia: Opinion for future implications and strategies |
| title_fullStr | Harnessing the power of proteins in modulation of miRNAs for targeting Iron deficiency Anemia: Opinion for future implications and strategies |
| title_full_unstemmed | Harnessing the power of proteins in modulation of miRNAs for targeting Iron deficiency Anemia: Opinion for future implications and strategies |
| title_short | Harnessing the power of proteins in modulation of miRNAs for targeting Iron deficiency Anemia: Opinion for future implications and strategies |
| title_sort | harnessing the power of proteins in modulation of mirnas for targeting iron deficiency anemia opinion for future implications and strategies |
| topic | miRNA microRNA anemia erythropoiesis protein iron deficiency anemia |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2025.1535498/full |
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