Dark Chocolate Intake May Reduce Fatigue and Mediate Cognitive Function and Gray Matter Volume in Healthy Middle-Aged Adults

Background. Dark chocolate has attracted attention for its potential for cognitive improvement. Though some reports indicate that dark chocolate is good for cognitive function, others raise doubts. This inconsistency in past results reflecting the relationship between dark chocolate and cognitive fu...

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Main Authors: Kiyotaka Nemoto, Keisuke Kokubun, Yousuke Ogata, Yasuharu Koike, Tetsuaki Arai, Yoshinori Yamakawa
Format: Article
Language:English
Published: Wiley 2022-01-01
Series:Behavioural Neurology
Online Access:http://dx.doi.org/10.1155/2022/6021811
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author Kiyotaka Nemoto
Keisuke Kokubun
Yousuke Ogata
Yasuharu Koike
Tetsuaki Arai
Yoshinori Yamakawa
author_facet Kiyotaka Nemoto
Keisuke Kokubun
Yousuke Ogata
Yasuharu Koike
Tetsuaki Arai
Yoshinori Yamakawa
author_sort Kiyotaka Nemoto
collection DOAJ
description Background. Dark chocolate has attracted attention for its potential for cognitive improvement. Though some reports indicate that dark chocolate is good for cognitive function, others raise doubts. This inconsistency in past results reflecting the relationship between dark chocolate and cognitive function indicates the potential existence of factors that mediate between dark chocolate intake and cognitive function. Methods. With the hypothesis that fatigue may be one such mediating factor, we performed a four-week randomized control study to seek a link between dark chocolate consumption, cognitive function, fatigue, and the brain in middle-aged adults. Results. We found that dark chocolate reduced mental and physical fatigue, and a path analysis revealed that it enhanced vitality, executive function, memory, and gray matter volume both directly and indirectly. Fatigue reduction was also associated with an improvement in physical function, which had a positive impact on emotional functioning, relief of bodily pain, and social functioning. Conclusions. Our results suggest that dark chocolate may help reduce fatigue in individuals, leading to improvements in brain health and various cognitive functions as well as in quality of life.
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series Behavioural Neurology
spelling doaj-art-24941febd4a8415da693fdf4c7426f6c2025-02-03T00:59:37ZengWileyBehavioural Neurology1875-85842022-01-01202210.1155/2022/6021811Dark Chocolate Intake May Reduce Fatigue and Mediate Cognitive Function and Gray Matter Volume in Healthy Middle-Aged AdultsKiyotaka Nemoto0Keisuke Kokubun1Yousuke Ogata2Yasuharu Koike3Tetsuaki Arai4Yoshinori Yamakawa5Department of PsychiatryOpen Innovation InstituteInstitute of Innovative ResearchInstitute of Innovative ResearchDepartment of PsychiatryDepartment of Global StudiesBackground. Dark chocolate has attracted attention for its potential for cognitive improvement. Though some reports indicate that dark chocolate is good for cognitive function, others raise doubts. This inconsistency in past results reflecting the relationship between dark chocolate and cognitive function indicates the potential existence of factors that mediate between dark chocolate intake and cognitive function. Methods. With the hypothesis that fatigue may be one such mediating factor, we performed a four-week randomized control study to seek a link between dark chocolate consumption, cognitive function, fatigue, and the brain in middle-aged adults. Results. We found that dark chocolate reduced mental and physical fatigue, and a path analysis revealed that it enhanced vitality, executive function, memory, and gray matter volume both directly and indirectly. Fatigue reduction was also associated with an improvement in physical function, which had a positive impact on emotional functioning, relief of bodily pain, and social functioning. Conclusions. Our results suggest that dark chocolate may help reduce fatigue in individuals, leading to improvements in brain health and various cognitive functions as well as in quality of life.http://dx.doi.org/10.1155/2022/6021811
spellingShingle Kiyotaka Nemoto
Keisuke Kokubun
Yousuke Ogata
Yasuharu Koike
Tetsuaki Arai
Yoshinori Yamakawa
Dark Chocolate Intake May Reduce Fatigue and Mediate Cognitive Function and Gray Matter Volume in Healthy Middle-Aged Adults
Behavioural Neurology
title Dark Chocolate Intake May Reduce Fatigue and Mediate Cognitive Function and Gray Matter Volume in Healthy Middle-Aged Adults
title_full Dark Chocolate Intake May Reduce Fatigue and Mediate Cognitive Function and Gray Matter Volume in Healthy Middle-Aged Adults
title_fullStr Dark Chocolate Intake May Reduce Fatigue and Mediate Cognitive Function and Gray Matter Volume in Healthy Middle-Aged Adults
title_full_unstemmed Dark Chocolate Intake May Reduce Fatigue and Mediate Cognitive Function and Gray Matter Volume in Healthy Middle-Aged Adults
title_short Dark Chocolate Intake May Reduce Fatigue and Mediate Cognitive Function and Gray Matter Volume in Healthy Middle-Aged Adults
title_sort dark chocolate intake may reduce fatigue and mediate cognitive function and gray matter volume in healthy middle aged adults
url http://dx.doi.org/10.1155/2022/6021811
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