Cancer-associated fibroblasts in carcinogenesis
Abstract In contemporary times, cancer poses the most significant threat to human life and safety. Scientists have relentlessly pursued the intricacies of carcinogenesis and explored ways to prevent and treat cancer. Carcinogenesis is a complex, multi-faceted, and multi-stage process, with numerous...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | Journal of Translational Medicine |
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| Online Access: | https://doi.org/10.1186/s12967-025-06071-8 |
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| _version_ | 1832594464738115584 |
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| author | Shufen Zhou Zekun Zhao Zhaojun Wang Hanzheng Xu Yijie Li Ke Xu Wei Li Jiahua Yang |
| author_facet | Shufen Zhou Zekun Zhao Zhaojun Wang Hanzheng Xu Yijie Li Ke Xu Wei Li Jiahua Yang |
| author_sort | Shufen Zhou |
| collection | DOAJ |
| description | Abstract In contemporary times, cancer poses the most significant threat to human life and safety. Scientists have relentlessly pursued the intricacies of carcinogenesis and explored ways to prevent and treat cancer. Carcinogenesis is a complex, multi-faceted, and multi-stage process, with numerous underlying causes, including inflammation and fibrosis. Cancer-associated fibroblasts (CAFs), however, occupy a pivotal and substantial role within the tumor microenvironment, facilitating carcinogenesis through diverse mechanisms such as creating inflammation, fostering a fibrotic tumor microenvironment, and immunosuppression. In this paper, we introduce the concept of carcinogenesis, explain its causes, describe the characteristics of CAFs and their sources, and highlight the roles and mechanisms of CAFs in promoting carcinogenesis. Ultimately, our aim is to contribute to the development of novel therapeutic strategies for cancer treatment. |
| format | Article |
| id | doaj-art-248e3a431e6245bd85c6127c51c3d4c2 |
| institution | Kabale University |
| issn | 1479-5876 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj-art-248e3a431e6245bd85c6127c51c3d4c22025-01-19T12:37:27ZengBMCJournal of Translational Medicine1479-58762025-01-0123111410.1186/s12967-025-06071-8Cancer-associated fibroblasts in carcinogenesisShufen Zhou0Zekun Zhao1Zhaojun Wang2Hanzheng Xu3Yijie Li4Ke Xu5Wei Li6Jiahua Yang7Department of General Surgery, Putuo Hospital, Shanghai University of Traditional Chinese MedicineDepartment of General Surgery, Tongji Hospital, School of Medicine, Tongji UniversityDepartment of Thyroid and Breast Surgery, The DingLi Clinical, The Wenzhou Central Hospital, College of Wenzhou Medical UniversityDepartment of General Surgery, Putuo Hospital, Shanghai University of Traditional Chinese MedicineDepartment of General Surgery, Putuo Hospital, Shanghai University of Traditional Chinese MedicineInstitute of Translational Medicine, Shanghai UniversityDepartment of General Surgery, Putuo Hospital, Shanghai University of Traditional Chinese MedicineDepartment of General Surgery, Putuo Hospital, Shanghai University of Traditional Chinese MedicineAbstract In contemporary times, cancer poses the most significant threat to human life and safety. Scientists have relentlessly pursued the intricacies of carcinogenesis and explored ways to prevent and treat cancer. Carcinogenesis is a complex, multi-faceted, and multi-stage process, with numerous underlying causes, including inflammation and fibrosis. Cancer-associated fibroblasts (CAFs), however, occupy a pivotal and substantial role within the tumor microenvironment, facilitating carcinogenesis through diverse mechanisms such as creating inflammation, fostering a fibrotic tumor microenvironment, and immunosuppression. In this paper, we introduce the concept of carcinogenesis, explain its causes, describe the characteristics of CAFs and their sources, and highlight the roles and mechanisms of CAFs in promoting carcinogenesis. Ultimately, our aim is to contribute to the development of novel therapeutic strategies for cancer treatment.https://doi.org/10.1186/s12967-025-06071-8Cancer-associated fibroblastsCarcinogenesisBreast cancerColorectal cancer |
| spellingShingle | Shufen Zhou Zekun Zhao Zhaojun Wang Hanzheng Xu Yijie Li Ke Xu Wei Li Jiahua Yang Cancer-associated fibroblasts in carcinogenesis Journal of Translational Medicine Cancer-associated fibroblasts Carcinogenesis Breast cancer Colorectal cancer |
| title | Cancer-associated fibroblasts in carcinogenesis |
| title_full | Cancer-associated fibroblasts in carcinogenesis |
| title_fullStr | Cancer-associated fibroblasts in carcinogenesis |
| title_full_unstemmed | Cancer-associated fibroblasts in carcinogenesis |
| title_short | Cancer-associated fibroblasts in carcinogenesis |
| title_sort | cancer associated fibroblasts in carcinogenesis |
| topic | Cancer-associated fibroblasts Carcinogenesis Breast cancer Colorectal cancer |
| url | https://doi.org/10.1186/s12967-025-06071-8 |
| work_keys_str_mv | AT shufenzhou cancerassociatedfibroblastsincarcinogenesis AT zekunzhao cancerassociatedfibroblastsincarcinogenesis AT zhaojunwang cancerassociatedfibroblastsincarcinogenesis AT hanzhengxu cancerassociatedfibroblastsincarcinogenesis AT yijieli cancerassociatedfibroblastsincarcinogenesis AT kexu cancerassociatedfibroblastsincarcinogenesis AT weili cancerassociatedfibroblastsincarcinogenesis AT jiahuayang cancerassociatedfibroblastsincarcinogenesis |