Neonatal Cholestasis: A Red Alert for the Jaundiced Newborn
Neonatal jaundice may indicate cholestasis rather than a benign, physiological condition. Any four-week-old newborn with persistent jaundice should have a fractionated bilirubin screen to determine whether the hyperbilirubinemia is unconjugated. Conjugated hyperbilirubinemia, a hallmark of neonatal...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2000-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2000/657368 |
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| Summary: | Neonatal jaundice may indicate cholestasis rather
than a benign, physiological condition. Any four-week-old newborn
with persistent jaundice should have a fractionated bilirubin
screen to determine whether the hyperbilirubinemia is unconjugated.
Conjugated hyperbilirubinemia, a hallmark of neonatal
cholestasis, is pathological and requires further investigation.
These infants need prompt diagnosis, early intervention and careful
follow-up to ensure continued growth and development. Recent
progress in the physiology of bile flow is reviewed, and the
evaluation and management of neonatal cholestasis are summarized.
Further advances in delineating the cellular and molecular
processes that regulate bile acid metabolism in both health and
disease will lead to a greater understanding of the conditions causing
neonatal cholestasis. Unravelling the etiopathogenesis of
these neonatal cholestatic disorders will allow the development of
novel diagnostic and therapeutic interventions that ultimately
will effectuate the prognosis for these young patients. |
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| ISSN: | 0835-7900 |