The Obesity Paradox and Cardiorespiratory Fitness
Cardiorespiratory fitness as an explanation for the obesity paradox warrants further examination. We evaluated independent and joint associations of cardiorespiratory fitness and adiposity with all-cause mortality in 811 middle-aged (age, 53.3±7.2 years) male never smokers without documented cardiop...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Obesity |
| Online Access: | http://dx.doi.org/10.1155/2012/951582 |
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| author | Paul A. McAuley Nancy S. Smith Brian T. Emerson Jonathan N. Myers |
| author_facet | Paul A. McAuley Nancy S. Smith Brian T. Emerson Jonathan N. Myers |
| author_sort | Paul A. McAuley |
| collection | DOAJ |
| description | Cardiorespiratory fitness as an explanation for the obesity paradox warrants further examination. We evaluated independent and joint associations of cardiorespiratory fitness and adiposity with all-cause mortality in 811 middle-aged (age, 53.3±7.2 years) male never smokers without documented cardiopulmonary disease or diabetes from the Veterans Exercise Testing Study (VETS). Cardiorespiratory fitness was quantified in metabolic equivalents (METs) using final treadmill speed and grade achieved on a maximal exercise test. Subjects were grouped for analysis by METs: unfit (lowest third) and fit (upper two-thirds); and by body mass index (kg/m2): nonobese (18.5−29.9) and obese (≥30.0). Associations of baseline fitness and adiposity measures with all-cause mortality were determined by Cox proportional hazards analysis adjusted for age, ethnicity, hypertension, hypercholesterolemia, family history of coronary artery disease, and cardiovascular medication use. In multivariate analysis, mortality risk for obese/fit men did not differ significantly from the nonobese/fit reference group. However, compared to the reference group, nonobese and obese unfit men were 2.2 (𝑃=0.01) and 1.9 (𝑃=0.03) times more likely to die, respectively. Cardiorespiratory fitness altered the obesity paradox such that mortality risk was lower for both obese and nonobese men who were fit. |
| format | Article |
| id | doaj-art-24819daf21dd4c0c88d6871d366852b2 |
| institution | Kabale University |
| issn | 2090-0708 2090-0716 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Obesity |
| spelling | doaj-art-24819daf21dd4c0c88d6871d366852b22025-02-03T06:00:18ZengWileyJournal of Obesity2090-07082090-07162012-01-01201210.1155/2012/951582951582The Obesity Paradox and Cardiorespiratory FitnessPaul A. McAuley0Nancy S. Smith1Brian T. Emerson2Jonathan N. Myers3Department of Human Performance and Sport Sciences, Winston-Salem State University, C024 Anderson, 601 S Martin Luther King Jr Drive, Winston-Salem, NC 27110, USADepartment of Physical Therapy, Winston-Salem State University, Winston-Salem, NC 27110, USADepartment of Physical Therapy, Winston-Salem State University, Winston-Salem, NC 27110, USADepartment of Cardiology, Division of Cardiovascular Medicine, Veterans Affairs Palo Alto Health Care System, Stanford University, Palo Alto, CA 94304, USACardiorespiratory fitness as an explanation for the obesity paradox warrants further examination. We evaluated independent and joint associations of cardiorespiratory fitness and adiposity with all-cause mortality in 811 middle-aged (age, 53.3±7.2 years) male never smokers without documented cardiopulmonary disease or diabetes from the Veterans Exercise Testing Study (VETS). Cardiorespiratory fitness was quantified in metabolic equivalents (METs) using final treadmill speed and grade achieved on a maximal exercise test. Subjects were grouped for analysis by METs: unfit (lowest third) and fit (upper two-thirds); and by body mass index (kg/m2): nonobese (18.5−29.9) and obese (≥30.0). Associations of baseline fitness and adiposity measures with all-cause mortality were determined by Cox proportional hazards analysis adjusted for age, ethnicity, hypertension, hypercholesterolemia, family history of coronary artery disease, and cardiovascular medication use. In multivariate analysis, mortality risk for obese/fit men did not differ significantly from the nonobese/fit reference group. However, compared to the reference group, nonobese and obese unfit men were 2.2 (𝑃=0.01) and 1.9 (𝑃=0.03) times more likely to die, respectively. Cardiorespiratory fitness altered the obesity paradox such that mortality risk was lower for both obese and nonobese men who were fit.http://dx.doi.org/10.1155/2012/951582 |
| spellingShingle | Paul A. McAuley Nancy S. Smith Brian T. Emerson Jonathan N. Myers The Obesity Paradox and Cardiorespiratory Fitness Journal of Obesity |
| title | The Obesity Paradox and Cardiorespiratory Fitness |
| title_full | The Obesity Paradox and Cardiorespiratory Fitness |
| title_fullStr | The Obesity Paradox and Cardiorespiratory Fitness |
| title_full_unstemmed | The Obesity Paradox and Cardiorespiratory Fitness |
| title_short | The Obesity Paradox and Cardiorespiratory Fitness |
| title_sort | obesity paradox and cardiorespiratory fitness |
| url | http://dx.doi.org/10.1155/2012/951582 |
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