CK2α-mediated phosphorylation of DUB3 promotes YAP1 stability and oncogenic functions

CK2α-mediated phosphorylation of DUB3 promotes YAP1 stability and oncogenic functions

Abstract The aberrant upregulation of Yes-associated protein 1 (YAP1) in a variety of solid cancers contributes to tumor progression and poor clinical outcomes, rendering it an appealing therapeutic target. However, effective therapies to directly target YAP1 remain challenging. In this study, we pe...

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Main Authors: Lei Huang, Yalei Wen, Qin Guo, Caishi Zhang, Xiao Yang, Mei Li, YiXia Liu, Xinying Li, Jiaxin Tang, Xiaofeng Zhou, Qi Qi, Haoxing Zhang, Tongzheng Liu
Format: Article
Language:English
Published: Nature Publishing Group 2025-01-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-024-07323-z
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https://doi.org/10.1038/s41419-024-07323-z

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