Remarkable Presentation: Anaplastic Thyroid Carcinoma Arising from Chronic Hyperthyroidism
Background. Undifferentiated anaplastic carcinoma rarely develops from chronic hyperthyroidism. Although acute hyperthyroidism can develop prior to anaplastic transformation, chronic hyperthyroidism was thought to be a protective measure against thyroid malignancy. Methods. A 79-year-old female pres...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2018/7261264 |
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| author | Habib G. Zalzal Jeffson Chung Jessica A. Perini |
| author_facet | Habib G. Zalzal Jeffson Chung Jessica A. Perini |
| author_sort | Habib G. Zalzal |
| collection | DOAJ |
| description | Background. Undifferentiated anaplastic carcinoma rarely develops from chronic hyperthyroidism. Although acute hyperthyroidism can develop prior to anaplastic transformation, chronic hyperthyroidism was thought to be a protective measure against thyroid malignancy. Methods. A 79-year-old female presented acutely to the hospital with dyspnea. She had been taking methimazole for chronic hyperthyroidism due to toxic thyroid nodules, previously biopsied as benign. Upon admission, imaging showed tracheal compression, requiring a total thyroidectomy with tracheostomy for airway management. Results. Pathology demonstrated undifferentiated anaplastic thyroid carcinoma. The patient passed away shortly after hospital discharge. Despite treatment with methimazole for many years, abrupt enlargement of her toxic multinodular goiter was consistent with malignant transformation. Chronic hyperthyroidism and toxic nodules are rarely associated with thyroid malignancy, with only one previous report documenting association with anaplastic thyroid carcinoma. Conclusion. Progressive thyroid enlargement and acute worsening of previously controlled hyperthyroidism should promote concern for disease regardless of baseline thyroid function. |
| format | Article |
| id | doaj-art-2468fa6f4d5341278bbf28fe6e080155 |
| institution | Kabale University |
| issn | 2090-6501 2090-651X |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Endocrinology |
| spelling | doaj-art-2468fa6f4d5341278bbf28fe6e0801552025-02-03T05:53:58ZengWileyCase Reports in Endocrinology2090-65012090-651X2018-01-01201810.1155/2018/72612647261264Remarkable Presentation: Anaplastic Thyroid Carcinoma Arising from Chronic HyperthyroidismHabib G. Zalzal0Jeffson Chung1Jessica A. Perini2Department of Otolaryngology-Head and Neck Surgery, West Virginia University School of Medicine, Morgantown, WV, USADepartment of Otolaryngology-Head and Neck Surgery, West Virginia University School of Medicine, Morgantown, WV, USASection of Endocrinology, Department of Internal Medicine, West Virginia University School of Medicine, Morgantown, WV, USABackground. Undifferentiated anaplastic carcinoma rarely develops from chronic hyperthyroidism. Although acute hyperthyroidism can develop prior to anaplastic transformation, chronic hyperthyroidism was thought to be a protective measure against thyroid malignancy. Methods. A 79-year-old female presented acutely to the hospital with dyspnea. She had been taking methimazole for chronic hyperthyroidism due to toxic thyroid nodules, previously biopsied as benign. Upon admission, imaging showed tracheal compression, requiring a total thyroidectomy with tracheostomy for airway management. Results. Pathology demonstrated undifferentiated anaplastic thyroid carcinoma. The patient passed away shortly after hospital discharge. Despite treatment with methimazole for many years, abrupt enlargement of her toxic multinodular goiter was consistent with malignant transformation. Chronic hyperthyroidism and toxic nodules are rarely associated with thyroid malignancy, with only one previous report documenting association with anaplastic thyroid carcinoma. Conclusion. Progressive thyroid enlargement and acute worsening of previously controlled hyperthyroidism should promote concern for disease regardless of baseline thyroid function.http://dx.doi.org/10.1155/2018/7261264 |
| spellingShingle | Habib G. Zalzal Jeffson Chung Jessica A. Perini Remarkable Presentation: Anaplastic Thyroid Carcinoma Arising from Chronic Hyperthyroidism Case Reports in Endocrinology |
| title | Remarkable Presentation: Anaplastic Thyroid Carcinoma Arising from Chronic Hyperthyroidism |
| title_full | Remarkable Presentation: Anaplastic Thyroid Carcinoma Arising from Chronic Hyperthyroidism |
| title_fullStr | Remarkable Presentation: Anaplastic Thyroid Carcinoma Arising from Chronic Hyperthyroidism |
| title_full_unstemmed | Remarkable Presentation: Anaplastic Thyroid Carcinoma Arising from Chronic Hyperthyroidism |
| title_short | Remarkable Presentation: Anaplastic Thyroid Carcinoma Arising from Chronic Hyperthyroidism |
| title_sort | remarkable presentation anaplastic thyroid carcinoma arising from chronic hyperthyroidism |
| url | http://dx.doi.org/10.1155/2018/7261264 |
| work_keys_str_mv | AT habibgzalzal remarkablepresentationanaplasticthyroidcarcinomaarisingfromchronichyperthyroidism AT jeffsonchung remarkablepresentationanaplasticthyroidcarcinomaarisingfromchronichyperthyroidism AT jessicaaperini remarkablepresentationanaplasticthyroidcarcinomaarisingfromchronichyperthyroidism |